1.6: Mass Spectrometry
- Page ID
- 38586
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- Mass spectrometry operates on the principle that:
- Compound specific ion fragments can be measured and quanitified
- Charged particles moving through a magnetic field can be separated from other charges particles according to their mass-to-charge ratios
- Molecules being analyzed by mass spectrometry must be in the gaseous state
- Bombardment of molecules by high energy electrons causes ions to be formed
- All of the above
- The molecular ion provides useful information about:
- The amount of energy required for ionization
- The molecular weight and information about the possible structure of the molecule
- The relative intensities of the fragments formed during full scan analysis
- The analytical purity as well as the intensity of the parent ion
- All of the above
- The main advantage of Electron Ionization is that:
- The resulting fragmentation is extensive and provides significant structural information about the molecule
- It is a much faster ionization process than other ionization techniques such as chemical ionization
- It is a soft ionization process that maximizes the ions life time
- All of the above
- None of the above
- Chemical Ionization is a process that:
- Generates full scan spectra characteristic of the molecule being analyzed
- Is only used to identify large molecules such as proteins and peptides
- Generates relatively stable ions of high intensity due to its gentle ionization
- All of the above
- None of the above
- The main advantage of LC/MS over GC/MS is:
- It has a significant cost advantage
- It is simpler and faster to use
- It may be more suitable for compounds that are less volatile or thermally labile
- All of the above
- None of the above
- The main disadvantage of LC/MS over GC/MS is:
- The difficulty of converting molecules of interest that are solvated in liquid to the gaseous form
- Interfacing helium gas to serve as the mobile phase carrier gas
- Bombarding of the liquid phase by high energy electrons to generate positive ions
- All of the above
- None of the above
- Answer
-
- e (p. 173)
- b (p. 177)
- a (p. 176,179)
- c (p. 176)
- c (p. 182-183)
- a (p. 182-183)