Blood vessels are flexible tubes that carry blood, associated oxygen, nutrients, water, and hormones throughout the body.
- Differentiate among the structure of arteries, veins, and capillaries
- Blood vessels consist of arteries, arterioles, capillaries, venules, and veins. Vessel networks deliver blood to all tissues in a directed and regulated manner.
- Arteries and veins are composed of three tissue layers.
- The thick outermost layer of a vessel (tunica adventitia or tunica externa ) is made of connective tissue.
- The middle layer ( tunica media ) is thicker and contains more contractile tissue in arteries than in veins. It consists of circularly arranged elastic fibers, connective tissue, and smooth muscle cells.
- The inner layer ( tunica intima ) is the thinnest layer, comprised of a single layer of endothelium supported by a subendothelial layer.
- Capillaries consist of a single layer of endothelium and associated connective tissue.
- tunica intima: The innermost layer of a blood vessel.
- tunica externa: The outermost layer of a blood vessel.
- capillary: Any of the small blood vessels that connect arteries to veins.
- tunica media: The middle layer of a blood vessel.
- anastomosis: The junction between blood vessels.
Blood vessels are key components of the systemic and pulmonary circulatory systems that distribute blood throughout the body. There are three major types of blood vessels: arteries that carry blood away from the heart, branching into smaller arterioles throughout the body and eventually forming the capillary network. The latter facilitates efficient chemical exchange between tissue and blood. Capillaries in turn merge into venules, then into larger veins responsible for returning the blood to the heart. The junctions between vessels are called anastomoses.
Arteries and veins are comprised of three distinct layers while the much smaller capillaries are composed of a single layer.
The inner layer (tunica intima) is the thinnest layer, formed from a single continuous layer of endothelial cells and supported by a subendothelial layer of connective tissue and supportive cells. In smaller arterioles or venules, this subendothelial layer consists of a single layer of cells, but can be much thicker in larger vessels such as the aorta. The tunica intima is surrounded by a thin membrane comprised of elastic fibers running parallel to the vessel. Capillaries consist only of the thin endothelial layer of cells with an associated thin layer of connective tissue.
Surrounding the tunica intima is the tunica media, comprised of smooth muscle cells and elastic and connective tissues arranged circularly around the vessel. This layer is much thicker in arteries than in veins. Fiber composition also differs; veins contain fewer elastic fibers and function to control caliber of the arteries, a key step in maintaining blood pressure.
The outermost layer is the tunica externa or tunica adventitia, composed entirely of connective fibers and surrounded by an external elastic lamina which functions to anchor vessels with surrounding tissues. The tunica externa is often thicker in veins to prevent collapse of the blood vessel and provide protection from damage since veins may be superficially located.
Structure of the Artery Wall: This diagram of the artery wall indicates the smooth muscle, external elastic membrane, endothelium, internal elastic membrane, tunica externa, tunica media, and tunica intima.
A major structural difference between arteries and veins is the presence of valves. In arteries, the blood is pumped under pressure from the heart, so backflow cannot occur. However, passing through the capillary network results in a decrease in blood pressure, meaning that backflow of blood is possible in veins. To counteract this, veins contain numerous one-direction valves that prevent backflow.