17.2: Heart Anatomy

Location of the Heart

The human heart is located within the thoracic cavity, medially between the lungs in the region known as the mediastinum. The mediastinum also includes the portions of the major blood vessels, the trachea, and the esophagus that are positioned between the lungs medially. Figure $\PageIndex{1}$ shows the position of the heart within the thoracic cavity. Within the mediastinum, the heart is separated from the other mediastinal structures and is held in place by a tough wrapping known as the pericardium, or pericardial sac. The sac also limits the range of motion of the heart as it beats. The double layered pericardial sac creates a thin space surrounding the heart called the pericardial cavity that is filled with serous fluid to prevent friction as the heart beats.

The dorsal surface of the heart lies near the bodies of the vertebrae and its anterior surface sits deep to the sternum and costal cartilages. The great veins, the superior and inferior venae cavae, and the great arteries, the aorta and pulmonary trunk, are attached to the superior surface of the heart, called the base. The base of the heart is located at the level of the third costal cartilage, as seen in Figure $\PageIndex{1}$. The inferior tip of the heart, the apex, lies just to the left of the sternum between the junction of the fourth and fifth ribs near their articulation with the costal cartilages. The heart is also rotated slightly around its vertical axis such that the more of the right side of the heart is visible in an anterior view while more of the left side is visible in a posterior view. It is important to remember the position and orientation of the heart when placing a stethoscope on the chest of a patient and listening for heart sounds, and also when looking at images taken from a midsagittal perspective. The slight deviation of the apex to the left is reflected in a depression in the medial surface of the inferior lobe of the left lung, called the cardiac notch.

The heart is positioned between the lungs at the center of the thoracic cavity in a space called the mediastinum. — Figure $\PageIndex{1}$: Position of the Heart in the Thorax. The heart is located within the thoracic cavity, medially between the lungs in the mediastinum. It is about the size of a fist, is broad at the top, and tapers toward the base. (Image credit: "Heart Position in Thorax" by OpenStax is licensed under CC BY 3.0)

EVERYDAY CONNECTION

CPR

The position of the heart in the torso between the vertebrae and sternum (see Figure $\PageIndex{1}$ for the position of the heart within the thorax) allows for individuals to apply an emergency technique known as cardiopulmonary resuscitation (CPR) if the heart of a patient should stop. If one hand is placed over the other in the middle of the chest about two finger-widths superior to the xiphoid process (Figure $\PageIndex{2}$), it is possible to manually compress the blood within the heart enough to push some of the blood within it into the pulmonary and systemic circuits. This is particularly critical for the brain, as irreversible damage and death of neurons occur within minutes of loss of blood flow. Current standards call for compression of the chest at least 5 cm deep and at a rate of 100 compressions per minute, a rate equal to the beat in “Staying Alive,” recorded in 1977 by the Bee Gees. If you are unfamiliar with this song, a version is available on www.youtube.com. At this stage, the emphasis is on performing high-quality chest compressions, rather than providing artificial respiration. CPR is generally performed until the patient regains spontaneous contraction or is declared dead by an experienced healthcare professional.

Proper hand placement for chest compressions during Cardio-Pulmonary Resuscitation (CPR) is at the middle of the chest several finger-widths superior to the xiphoid process at the base of the sternum.. — Figure $\PageIndex{2}$: CPR Technique. If the heart should stop, CPR can maintain the flow of blood until the heart resumes beating. By applying pressure to the sternum, the blood within the heart will be squeezed out of the heart and into the circulation. Proper positioning of the hands on the sternum to perform CPR would be between the lines at T4 and T9, or directly superior to two finger-widths above the xiphoid process. (Image credit: "CPR Technique" by OpenStax College is licensed under CC BY 3.0)

When performed by untrained or overzealous individuals, CPR can result in broken ribs or a broken sternum, and can inflict additional severe damage on the patient. It is also possible, if the hands are placed too low on the sternum, to manually drive the xiphoid process into the liver, a consequence that may prove fatal for the patient. Proper training is essential. This proven life-sustaining technique is so valuable that virtually all medical personnel as well as concerned members of the public should be certified and routinely recertified in its application. CPR courses are offered at a variety of locations, including colleges, hospitals, the American Red Cross, and some commercial companies. They normally include practice of the compression technique on a mannequin.

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Visit the American Heart Association to help locate a course near your home in the United States. There are also many other national and regional heart associations that offer the same service, depending upon the location.

Shape and Size of the Heart

The shape of the heart is similar to a pinecone, rather broad at the superior surface and tapering to the apex (Figure $\PageIndex{1}$). A typical heart is approximately the size of your fist: 12 cm (5 in) in length, 8 cm (3.5 in) wide, and 6 cm (2.5 in) in thickness. Given the size difference between most members of the sexes, the weight of a female heart is approximately 250–300 grams (9 to 11 ounces), and the weight of a male heart is approximately 300–350 grams (11 to 12 ounces).

The heart of a well-trained athlete, especially one specializing in aerobic sports, can be considerably larger than this. Cardiac muscle responds to exercise in a manner similar to that of skeletal muscle. That is, exercise results in the addition of protein myofilaments that increase the size of the individual cells without increasing their numbers, a concept called hypertrophy. Hearts of athletes can pump blood more effectively at lower rates than those of non-athletes. Enlarged hearts are not always a result of exercise; they can result from pathologies, such as hypertrophic cardiomyopathy. The cause of an abnormally enlarged heart muscle is unknown, but hearts with this condition often have mutation(s) in one of the proteins of the sarcomere, such as myosin or troponin (Popa-Fotea et al, 2019). The condition can be inherited, is often undiagnosed and can cause sudden death in apparently otherwise healthy young people.

Chambers and Circulation through the Heart

The human heart consists of four chambers: The left side and the right side each have one atrium and one ventricle. Each of the upper chambers, the right atrium and the left atrium (plural = atria), acts as a receiving chamber and contracts to push blood into the lower chambers, the right ventricle and the left ventricle. The ventricles serve as the primary pumping chambers of the heart, propelling blood to the lungs or to the rest of the body.

There are two distinct but linked circuits in the human blood circulation called the pulmonary and systemic circuits. Although both circuits transport blood and everything it carries, we can initially view the circuits from the point of view of gases. The pulmonary circuit transports blood to and from the lungs, where it picks up oxygen and delivers carbon dioxide for exhalation. The systemic circuit transports oxygenated blood to virtually all of the tissues of the body and returns relatively deoxygenated blood and carbon dioxide to the heart to be sent back to the pulmonary circulation.

The right ventricle pumps deoxygenated blood into the pulmonary trunk, which ascends across the anterior surfaces of the ascending aorta and left atrium toward a bifurcation into the left and right pulmonary arteries. The right pulmonary artery passes under the aortic arch and delivers blood to the right lung. The left pulmonary artery delivers blood to the left lung. These arteries in turn branch many times in each lung before reaching the pulmonary capillaries, where gas exchange occurs: carbon dioxide exits the blood and oxygen enters. The pulmonary trunk, arteries, and their branches are the only arteries in the post-natal body that carry relatively deoxygenated blood. Highly oxygenated blood returning from the pulmonary capillaries in the lungs passes through a series of vessels that join together to form the pulmonary veins—the only post-natal veins in the body that carry highly oxygenated blood. The pulmonary veins conduct blood into the right and left sides of the left atrium posteriorly, which pumps the blood into the left ventricle, which in turn pumps oxygenated blood into the aorta, which ascends out of the left ventricle posterior to the pulmonary trunk, arches over the top of the heart and descends posterior to the heart. The aorta branches to deliver oxygenated blood throughout the body via the systemic circuit. Eventually, blood reaches systemic capillaries, where exchange with the tissue fluid and cells of the body occurs. In this case, oxygen and nutrients exit the systemic capillaries to be used by the cells in their metabolic processes, and carbon dioxide and waste products will enter the blood.

The blood exiting the systemic capillaries is lower in oxygen concentration than when it entered. The capillaries will ultimately unite to form venules, joining to form ever-larger veins, eventually flowing into the two major systemic veins, the superior vena cava and the inferior vena cava, which return blood into the right atrium. The blood in the superior and inferior venae cavae flows into the right atrium, which pumps blood into the right ventricle. This process of blood circulation continues as long as the individual remains alive. Understanding the flow of blood through the pulmonary and systemic circuits is critical to all health professions (Figure $\PageIndex{3}$).

Labeled diagrams showing the flow of blood in the two major circuits of blood flow in the human Body. In the pulmonary circuit, blood flows from the right side of the heart to the lungs to pick up oxygen and returns to the left side of the heart. In the systemic circuit, blood flows from the left side of the heart to deliver oxygen to the tissues of the body and returns to the right side of the heart. — Figure $\PageIndex{3}$: Dual System of Human Blood Circulation. Blood flows from the right atrium to the right ventricle, where it is pumped into the pulmonary circuit. The blood in the branches of the pulmonary artery is low in oxygen but relatively high in carbon dioxide. Gas exchange occurs in the pulmonary capillaries (oxygen into the blood, carbon dioxide out), and blood high in oxygen and low in carbon dioxide is returned to the left atrium. From here, blood enters the left ventricle, which pumps it into the systemic circuit. Following exchange in the systemic capillaries (oxygen and nutrients out of the capillaries and carbon dioxide and wastes in), blood returns to the right atrium and the cycle is repeated. (Image credit: "Dual System of Human Circulation" by OpenStax is licensed under CC BY 3.0)

Membranes, Surface Features, and Layers

Our exploration of more in-depth heart structures begins by examining the membrane that surrounds the heart, the prominent surface features of the heart, and the layers that form the wall of the heart. Each of these components plays its own unique role in terms of function.

Membranes

The multi-layered membrane that directly surrounds the heart and defines the pericardial cavity is called the pericardium or pericardial sac. It also surrounds the “roots” of the major vessels, or the areas of closest proximity to the heart. The pericardium, which literally translates as “around the heart,” consists of two distinct sublayers: the sturdy outer fibrous pericardium and the inner serous pericardium. The fibrous pericardium is made of tough, dense irregular connective tissue that protects the heart and maintains its position in the thorax while also limiting the heart's motion during the heartbeat. The more delicate serous pericardium consists of two layers: the parietal pericardium, which is fused to the fibrous pericardium, and an inner visceral pericardium, or epicardium, which is fused to the heart and is part of the heart wall. The pericardial cavity, filled with lubricating serous fluid, lies between the epicardium and the parietal pericardium.

The serous layers of the pericardium consist of a simple squamous epithelium called a mesothelium, reinforced with a layer of areolar connective tissue. The areolar connective tissue connects the parietal pericardium to the fibrous pericardium while it connects the epicardium to the myocardium. The mesothelium secretes the lubricating serous fluid that fills the pericardial cavity and reduces friction as the heart contracts. Figure $\PageIndex{4}$ illustrates the pericardial membrane and the layers of the heart.

Layers of the Heart Wall and Pericardium (from deep to superficial: Endocardium, Myocardium, Epicardium, Pericardial cavity filled with Serous Fluid, Parietal Pericardium, Fibrous Pericardium) — Figure $\PageIndex{4}$: Pericardial Membranes and Layers of the Heart Wall. A cross-section of the pericardium and heart wall reveal the structure of the layers. The superficial fibrous pericardium is connected to the parietal pericardium that superficially lines the fluid-filled pericardial cavity. The epicardium that lines the deep side of the pericardial cavity is shared by the pericardium and the heart wall. The myocardium is the thickest portion of the heart wall positioned between the epicardium and the endocardium that lines the inside of the heart. (Image Credit: "Heart Wall" by Julie Jenks is licensed under CC BY 4.0 / A derivative from the original work)

DISORDERS OF THE...

Heart: Cardiac Tamponade

If excess fluid builds within the pericardial space, it can lead to a condition called cardiac tamponade, or pericardial tamponade. With each contraction of the heart, more fluid—in most instances, blood—accumulates within the pericardial cavity. In order to fill with blood for the next contraction, the heart must relax. However, the excess fluid in the pericardial cavity puts pressure on the heart and prevents full relaxation, so the chambers within the heart contain slightly less blood as they begin each heart cycle. Over time, less and less blood is ejected from the heart. If the fluid builds up slowly, as in hypothyroidism, the pericardial cavity may be able to expand gradually to accommodate this extra volume. Some cases of fluid in excess of one liter within the pericardial cavity have been reported. Rapid accumulation of as little as 100 mL of fluid following trauma may trigger cardiac tamponade. Other common causes include myocardial rupture, pericarditis, cancer, or even cardiac surgery. Removal of this excess fluid requires insertion of drainage tubes into the pericardial cavity. Premature removal of these drainage tubes, for example, following cardiac surgery, or clot formation within these tubes are causes of this condition. Untreated, cardiac tamponade can lead to death.

Surface Features of the Heart

Inside the pericardium, the surface features of the heart are visible, including the four chambers. There is a superficial leaf-like extension of each atrium near the superior surface of the heart, one on each side of the pulmonary trunk, called an auricle—a name that means “ear like”—because its shape resembles the external ear of a human (Figure $\PageIndex{5}$). Auricles are relatively thin-walled structures that can fill with blood and empty into the atria or upper chambers of the heart. You may also hear them referred to as atrial appendages. Also prominent along the superficial surfaces of the heart is a series of fat-filled grooves, each of which is known as a sulcus (plural = sulci). Major coronary blood vessels are located in these sulci. The deep coronary sulcus is located between the atria and ventricles. Located between the left and right ventricles are two additional sulci that are not as deep as the coronary sulcus. The anterior interventricular sulcus is visible on the anterior surface of the heart, whereas the posterior interventricular sulcus is visible on the posterior surface of the heart. Figure $\PageIndex{5}$ illustrates anterior and posterior views of the surface of the heart.

Labeled diagrams of the superficial anatomy of the heart with anterior and posterior views. — Figure $\PageIndex{5}$: External Anatomy of the Heart. Deep to the pericardium, the surface features of the heart are visible. (Image credit: "Surface Anatomy of the Heart" by OpenStax is licensed under CC BY 3.0)

Layers

The wall of the heart is composed of three layers of unequal thickness. From superficial to deep, these are the epicardium, the myocardium, and the endocardium (see Figure $\PageIndex{4}$). The outermost layer of the wall of the heart is also the innermost layer of the pericardium, the epicardium, or the visceral pericardium discussed earlier.

The middle and thickest layer is the myocardium, made largely of cardiac muscle cells along with the blood vessels that supply the myocardium and the nerve fibers that help regulate the heart. It is built upon a framework of dense connective tissue called the cardiac skeleton (covered in detail later in this section). It is the contraction of the myocardium that pumps blood through the heart and into the major arteries. The muscle pattern is elegant and complex, as the muscle cells swirl and spiral to form the chambers of the heart. To create this complex 3D structure, cardiac muscle cells approximately follow a figure 8 pattern around the atria and around the roots of the great vessels. Deeper ventricular muscles also form a figure 8 around the two ventricles and proceed toward the apex. More superficial layers of ventricular muscle wrap around both ventricles. This complex swirling pattern allows the heart to pump blood more effectively by decreasing the size of each chamber during contraction. Figure $\PageIndex{6}$ illustrates the arrangement of muscle cells.

Diagram of the spiral arrangement of cardiac muscle that forms figure 8 patterns around the atria, around the roots of the great vessels, and around the ventricles. — Figure $\PageIndex{6}$: Cardiac Musculature. The swirling pattern of cardiac muscle tissue contributes significantly to the heart’s ability to pump blood effectively. (Image credit: "Heart Musculature" by OpenStax is licensed under CC BY 3.0)

Although the ventricles on the right and left sides pump the same amount of blood per contraction, the muscle of the left ventricle is much thicker and better developed than that of the right ventricle. In order to overcome the high resistance required to pump blood into the long systemic circuit, the left ventricle must generate a great amount of pressure. The right ventricle does not need to generate as much pressure, since the pulmonary circuit is shorter and provides less resistance. Figure $\PageIndex{7}$ illustrates the differences in muscular thickness needed for each of the ventricles.

Diagram comparing the thickness of the myocardium in both the left and right ventricles. The myocardium of the left ventricle is significantly thicker to produce a stronger force to push the blood to the furthest destinations in the systemic circuit. — Figure $\PageIndex{7}$: Differences in Ventricular Muscle Thickness. The myocardium in the left ventricle is significantly thicker than that of the right ventricle. Both ventricles pump the same amount of blood, but the left ventricle must generate a much greater pressure to overcome greater resistance in the systemic circuit. The ventricles are shown in both relaxed and contracting states. Note the differences in the relative size of the lumens, the region inside each ventricle where the blood is contained. (Image credit: "Ventricular Muscle Thickness" by OpenStax is licensed under CC BY 3.0)

The innermost layer of the heart wall, the endocardium, is joined to the myocardium with a thin layer of areolar connective tissue. The endocardium lines the chambers where the blood circulates and covers the heart valves. It is made of simple squamous epithelium called endothelium, which is continuous with the endothelial lining of the blood vessels (Figure $\PageIndex{4}$).

Internal Structures of the Heart

Recall that the heart’s contraction cycle follows a dual pattern of circulation—the pulmonary and systemic circuits—because of the pairs of chambers that pump blood into the circulation. In order to develop a more precise understanding of cardiac function, it is first necessary to explore the internal anatomical structures in more detail.

This section explores the anatomy of the septa that divide the heart into four chambers, the cardiac skeleton that provides the supportive internal framework of the heart, and the features of each of the four chambers before describing in more detail the sequence of contractions in a single heart beat—the cardiac cycle—and the structure and function of the heart valves that work to keep blood flowing in one direction through the heart.

Septa of the Heart

The word septum is derived from the Latin for “something that encloses;” in this case, a septum (plural = septa) refers to a wall or partition that divides the heart into chambers. The septa are physical extensions of the myocardium lined with endocardium. Located between the two atria is the interatrial septum. Normally in an adult heart, the interatrial septum bears an oval-shaped depression known as the fossa ovalis, a remnant of an opening in the fetal heart known as the foramen ovale. The foramen ovale allowed blood in the fetal heart to pass directly from the right atrium to the left atrium, allowing some blood to bypass the pulmonary circuit. Within seconds after birth, a flap of tissue known as the septum primum that previously acted as a valve closes the foramen ovale and establishes the typical cardiac circulation pattern.

Between the two ventricles is a second septum known as the interventricular septum. Unlike the interatrial septum, the interventricular septum is normally intact after its formation during fetal development. It is substantially thicker than the interatrial septum, since the ventricles generate far greater pressure when they contract.

The septum between the atria and ventricles is known as the atrioventricular septum. It is marked by the presence of four openings that allow blood to move from the atria into the ventricles and from the ventricles into the pulmonary trunk and aorta. Located in each of these openings between the atria and ventricles is a valve, a specialized structure that ensures one-way flow of blood. The valves between the atria and ventricles are known generically as atrioventricular valves. The valves at the openings that lead to the pulmonary trunk and aorta are known generically as semilunar valves. The interventricular septum is visible in Figure $\PageIndex{8}$. In this figure, the atrioventricular septum has been removed to better show the atrioventricular valves, also known as the bicuspid and tricuspid valves; the interatrial septum is not visible, since its location is covered by the aorta and pulmonary trunk.

Labeled diagram of the internal anatomy visible in an anterior view of a frontal section of the heart. — Figure $\PageIndex{8}$: Internal Structures of the Heart. This anterior view of the heart shows the four chambers, the major vessels and their early branches, as well as the valves. The presence of the pulmonary trunk and aorta covers the interatrial septum, and the atrioventricular septum is cut away to show the atrioventricular valves. (Image credit: "Internal Anatomy of the Heart" by OpenStax is licensed under CC BY 3.0)

DISORDERS OF THE...

Heart: Heart Defects

One very common form of interatrial septum pathology is patent foramen ovale, which occurs when the septum primum does not close at birth, and the fossa ovalis is unable to fuse. The word patent is from the Latin root patens for “open.” It may be benign or asymptomatic, perhaps never being diagnosed, or in extreme cases, it may require surgical repair to close the opening permanently. As much as 20–25 percent of the general population may have a patent foramen ovale, but fortunately most have the benign, asymptomatic version. Patent foramen ovale is normally detected by auscultation of a heart murmur (an abnormal heart sound) and confirmed by imaging with an echocardiogram. Despite its prevalence in the general population, the causes of patent foramen ovale are unknown, and there are no known risk factors. In nonlife-threatening cases, it is better to monitor the condition than to risk heart surgery to repair and seal the opening.

Coarctation of the aorta is a congenital abnormal narrowing of the aorta that is normally located at the insertion of the ligamentum arteriosum (see Figure $\PageIndex{5}$), the remnant of the fetal shunt called the ductus arteriosus that connected the pulmonary trunk to the aorta; part of the bypass of the pulmonary circuit. If severe, this condition drastically restricts blood flow through this primary systemic artery, which is life threatening. In some individuals, the condition may be fairly benign and not detected until later in life. Detectable symptoms in an infant include difficulty breathing, poor appetite, trouble feeding, or failure to thrive. In older individuals, symptoms include dizziness, fainting, shortness of breath, chest pain, fatigue, headache, and nosebleeds. Treatment involves surgery to resect (remove) the affected region or angioplasty to open the abnormally narrow passageway. Studies have shown that the earlier the surgery is performed, the better the chance of survival.

A patent ductus arteriosus is a congenital condition in which the ductus arteriosus fails to close. The condition may range from severe to benign. Failure of the ductus arteriosus to close results in blood flowing from the higher pressure aorta into the lower pressure pulmonary trunk. This additional fluid moving toward the lungs increases pulmonary pressure and makes respiration difficult. Symptoms include shortness of breath (dyspnea), tachycardia, enlarged heart, a widened pulse pressure, and poor weight gain in infants. Treatments include surgical closure (ligation), manual closure using platinum coils or specialized mesh inserted via the femoral artery or vein, or nonsteroidal anti-inflammatory drugs to block the synthesis of prostaglandin E2, which maintains the vessel in an open position. If untreated, the condition can result in congestive heart failure.

Septal defects are not uncommon in individuals and may be congenital or caused by various disease processes. Tetralogy of Fallot is a congenital condition that may also occur from exposure to unknown environmental factors; it occurs when there is an opening in the interventricular septum caused by blockage of the pulmonary trunk, normally at the pulmonary semilunar valve. This allows blood that is relatively low in oxygen from the right ventricle to flow into the left ventricle and mix with the blood that is relatively high in oxygen. Symptoms include a distinct heart murmur, low blood oxygen percent saturation, dyspnea or difficulty in breathing, polycythemia, broadening (clubbing) of the fingers and toes, and in children, difficulty in feeding or failure to grow and develop. It is the most common cause of cyanosis following birth. The term “tetralogy” is derived from the four components of the condition, although only three may be present in an individual patient: pulmonary infundibular stenosis (rigidity of the pulmonary valve), overriding aorta (the aorta is shifted above both ventricles), ventricular septal defect (opening), and right ventricular hypertrophy (enlargement of the right ventricle). Other heart defects may also accompany this condition, which is typically confirmed by echocardiography imaging. Tetralogy of Fallot occurs in approximately 400 out of one million live births. Normal treatment involves extensive surgical repair, including the use of stents to redirect blood flow and replacement of valves and patches to repair the septal defect, but the condition has a relatively high mortality. Survival rates are currently 75 percent during the first year of life; 60 percent by 4 years of age; 30 percent by 10 years; and 5 percent by 40 years.

In the case of severe septal defects, including both Tetralogy of Fallot and patent foramen ovale, failure of the heart to develop properly can lead to a condition commonly known as a “blue baby.” Regardless of normal skin pigmentation, individuals with this condition have an insufficient supply of oxygenated blood, which leads to cyanosis, a blue or purple coloration of the skin, especially when active.

Septal defects are commonly first detected through auscultation, listening to the chest using a stethoscope. In this case, instead of hearing normal heart sounds attributed to the flow of blood and closing of heart valves, unusual heart sounds may be detected. This is often followed by medical imaging to confirm or rule out a diagnosis. In many cases, treatment may not be needed. Some common congenital heart defects are illustrated in Figure $\PageIndex{9}$.

Diagrams illustrating the abnormal anatomy associated with several common congenital defects of the heart. — Figure $\PageIndex{9}$: Congenital Heart Defects. (a) A patent foramen ovale defect is an abnormal opening in the interatrial septum, or more commonly, a failure of the foramen ovale to close. (b) Coarctation of the aorta is an abnormal narrowing of the aorta. (c) A patent ductus arteriosus is the failure of the ductus arteriosus to close. (d) Tetralogy of Fallot includes an abnormal opening in the interventricular septum that causes an enlarged right ventricle, a stenosed (narrowed) pulmonary semilunar valve, and the emergence of the aorta from both ventricles. (Image credit: "Congenital Heart Defects" by OpenStax is licensed under CC BY 3.0)

Cardiac Skeleton

Since these openings and valves structurally weaken the atrioventricular septum, the remaining tissue is heavily reinforced with dense irregular connective tissue of the cardiac skeleton, or skeleton of the heart. It includes four rings that surround the openings between the atria and ventricles, and the openings to the pulmonary trunk and aorta, and serve as the point of attachment for the heart valves. The cardiac skeleton also provides the structural framework against which the cardiac muscle contracts and forms an important insulating boundary in the heart's electrical conducting system.

Right Atrium

The right atrium serves as the receiving chamber for blood returning to the heart from the systemic circulation. The two major systemic veins, the superior and inferior venae cavae, and the large coronary vein called the coronary sinus empty into the right atrium. The superior vena cava drains blood from regions superior to the diaphragm: the head, neck, upper limbs, and the thoracic region. It empties into the superior and posterior portions of the right atrium. The inferior vena cava drains blood from areas inferior to the diaphragm: the lower limbs and abdominopelvic region of the body. It, too, empties into the posterior portion of the atria, but inferior to the opening of the superior vena cava. Immediately superior and slightly medial to the opening of the inferior vena cava on the posterior surface of the atrium is the opening of the coronary sinus. This thin-walled vessel drains most of the coronary veins that return systemic blood from the heart into the right atrium. The majority of the internal heart structures discussed in this and subsequent sections are illustrated in Figure $\PageIndex{8}$.

While the bulk of the internal surface of the right atrium is smooth, the depression of the fossa ovalis is medial, and the anterior surface demonstrates prominent ridges of muscle called the pectinate muscles, which are thought to help spread the electrical signals to contract and strengthen the contraction of the atria. The right auricle also has pectinate muscles. The left atrium does not have pectinate muscles except in the auricle.

The atria receive venous blood on a nearly continuous basis, allowing the heart to continue to receive blood even while the ventricles are contracting. While most ventricular filling occurs while the atria are relaxed, they do demonstrate a contractile phase and actively pump blood into the ventricles just prior to ventricular contraction. The opening between the right atrium and right ventricle is guarded by the tricuspid valve.

Right Ventricle

The right ventricle receives blood from the right atrium through the tricuspid valve. Each flap of the valve is attached to strong strands of connective tissue, the chordae tendineae, literally “tendinous cords,” or sometimes more poetically referred to as “heart strings.” There are several chordae tendineae associated with each of the flaps. They are composed of approximately 80 percent collagenous fibers with the remainder consisting of elastic fibers and endothelium. They connect each of the flaps to a papillary muscle. There are three papillary muscles in the right ventricle, called the anterior, posterior, and septal muscles, which correspond to the three sections of the valves.

When the myocardium of the ventricle contracts, pressure within the ventricular chamber rises. Blood, like any fluid, flows from higher pressure to lower pressure areas, in this case, toward the pulmonary trunk and the atrium. To prevent any potential backflow, the flaps of the tricuspid valve are pushed closed during ventricular contraction. The papillary muscles contract with the ventricular myocardium, generating tension on the chordae tendineae. This prevents the flaps of the valves from being forced into the atria and regurgitation of the blood back into the atria during ventricular contraction. Figure $\PageIndex{11}$ shows papillary muscles and chordae tendineae attached to the tricuspid valve.

Figure $\PageIndex{11}$: Chordae Tendineae and Papillary Muscles. In this frontal section, you can see papillary muscles attached to the tricuspid valve on the right as well as the mitral valve on the left via chordae tendineae. (Image credit: "Chordae Tendineae and Papillary Muscles" by CNX is licensed under CC BY 4.0 / A derivative from the original work)

The walls of the ventricle are lined with trabeculae carneae, ridges of cardiac muscle covered by endocardium (Figure $\PageIndex{11}$) that increase the surface area of the ventricular wall. Each papillary muscle is connected to the inferior ventricular myocardium by way of the trabeculae carneae (Axel, 2004). In addition to these muscular ridges, a band of cardiac muscle, also covered by endocardium, known as the moderator band (see Figure $\PageIndex{8}$) reinforces the thin walls of the right ventricle and plays a crucial role in cardiac conduction. It arises from the inferior portion of the interventricular septum and crosses the interior space of the right ventricle to connect with the inferior papillary muscle.

When the right ventricle contracts, it ejects blood into the pulmonary trunk, which branches into the left and right pulmonary arteries that carry deoxygenated blood to each lung. The superior surface of the right ventricle begins to taper as it approaches the pulmonary trunk. At the base of the pulmonary trunk is the pulmonary semilunar valve that prevents backflow from the pulmonary trunk when the ventricle relaxes.

Left Atrium

After exchange of gases in the pulmonary capillaries, freshly oxygenated blood returns to the left atrium via one of the four pulmonary veins. The left atrium does not contain pectinate muscles so its walls are smoother than in the right atrium, but it does have an auricle that includes pectinate ridges. Blood flows nearly continuously from the pulmonary veins back into the atrium, which acts as the receiving chamber, and from here through an open mitral valve, also known as the bicuspid valve, into the left ventricle. Most blood flows passively into the heart while both the atria and ventricles are relaxed, but toward the end of the ventricular relaxation period, the left atrium will contract, pumping blood into the ventricle. This atrial contraction accounts for approximately 20 percent of ventricular filling. The opening between the left atrium and ventricle is guarded by the mitral valve.

Left Ventricle

Recall that, although both sides of the heart will pump the same amount of blood, the muscular layer is much thicker in the left ventricle compared to the right (see Figure $\PageIndex{7}$). Like the right ventricle, the left also has trabeculae carneae, but there is no moderator band. The mitral valve is connected to papillary muscles via chordae tendineae. There are two papillary muscles in the left ventricle—the anterior and posterior—as opposed to three in the right ventricle.

The left ventricle is the major pumping chamber for the systemic circuit; it ejects blood into the aorta through the aortic semilunar valve.

Cardiac Cycle

The period of time that begins with ventricular relaxation and ends after both atria and both ventricles have contracted once is known as the cardiac cycle (Figure $\PageIndex{12}$). The period of contraction that the heart undergoes while it pumps blood into circulation is called systole. The period of relaxation that occurs as the chambers fill with blood is called diastole. Both the atria and ventricles undergo systole and diastole, and it is essential that these components be carefully regulated and coordinated to ensure blood is pumped efficiently to the body.

The cardiac cycle begins with the atria and ventricles relaxed (cardiac diastole). Blood returns to the right atrium via the superior and inferior venae cavae and coronary sinus and blood returns to the left atrium via four pulmonary veins. With the ventricles relaxed, the tricuspid and mitral valves are open, allowing a majority of blood to passively move inferiorly to begin filling the ventricles. Atrial systole forces the last 30 percent of blood remaining in each atrium into its connected ventricle to finish filling it prior to ventricular systole. The force of ventricular systole forces the blood from the right ventricle through the cusps of the pulmonary semilunar valve into the pulmonary trunk and forces the blood from the left ventricle through the cusps of the aortic semilunar valve into the ascending aorta.

The cardiac cycle can be described in three basic steps: cardiac diastole, then atrial systole, and finally ventricular systole. — Figure $\PageIndex{12}$: Cardiac Cycle. The cardiac cycle begins with all chambers of the heart in diastole, during which time the heart fills with blood and blood moves passively from each atrium to the connected ventricle. Then atrial systole pushes the remaining blood from each atrium into the connected ventricle. After the atria relax, ventricular diastole pushes the blood out into the great vessels of each circuit of blood flow. (Image credit: "Figure 40 03 03" by OpenStax is licensed under CC BY 4.0)

Heart Valve Structure and Function

A transverse section through the heart slightly above the level of the atrioventricular septum reveals all four heart valves along the same plane (Figure $\PageIndex{13}$). The valves ensure unidirectional blood flow through the heart. Between the right atrium and the right ventricle is the right atrioventricular valve, or tricuspid valve. It typically consists of three flaps, or leaflets, made of endocardium reinforced with additional dense connective tissue. Each flap is connected by several chordae tendineae to a papillary muscle that protrudes from the ventricular wall.

Labeled diagram of transverse section of heart showing the position of all four heart valves anchored in cardiac skeleton. In the anterior half of the heart are the semilunar valves. The anterior-most valve is the pulmonary valve with the aortic valve just posterior to it. In the posterior half of the heart are the atrioventricular valves: tricuspid valve on the right and the mitral valve on the left. — Figure $\PageIndex{13}$: Heart Valves. With the atria and major vessels removed, all four valves are clearly visible, although it is difficult to distinguish the three separate cusps of the tricuspid valve. (Image credit: "Heart Valves" by OpenStax is licensed under CC BY 3.0)

Located at the opening between the left atrium and left ventricle is the mitral valve, also called the bicuspid valve or the left atrioventricular valve. In a clinical setting, the valve is referred to as the mitral valve, rather than the bicuspid valve, as the actual number of cusps has been found to vary greatly among individuals (Gunnal et al, 2012). The cusps of the mitral valve are attached by chordae tendineae to two papillary muscles that project from the trabeculae carneae of the wall of the ventricle.

When the ventricles begin to contract, pressure within the ventricles rises and blood flows toward the area of lowest pressure, which is initially in the atria. This movement of blood causes the cusps of the tricuspid and mitral valves to close. The valve cusps are anchored to the papillary muscles by chordae tendineae. As the myocardium of the ventricle contracts, so do the papillary muscles. This creates tension on the chordae tendineae (see Figure $\PageIndex{15}$.b), helping to hold the cusps of the atrioventricular valves in place and preventing them from everting into the atria. During the relaxation phase of the cardiac cycle, the papillary muscles are also relaxed and the tension on the chordae tendineae is slight (see Figure $\PageIndex{14}$.b).

Emerging from the right ventricle at the base of the pulmonary trunk is the pulmonary semilunar valve, or the pulmonary valve; it is also known as the pulmonic valve. At the base of the aorta that emerges from the left ventricle is the aortic semilunar valve, or the aortic valve. The semilunar valves are both comprised of three small flaps of endothelium reinforced with dense connective tissue.

When the ventricle relaxes, the pressure differential causes blood to flow back towards the ventricle within the pulmonary trunk and aorta. This flow of blood fills the pocket-like flaps of each semilunar valve, causing the valve to close, disrupting the backflow of blood and producing an audible sound. Unlike the atrioventricular valves, there are no papillary muscles or chordae tendineae associated with the semilunar valves.

In Figure $\PageIndex{14}$.a, the two atrioventricular valves are open and the two semilunar valves are closed. This occurs when both atria and ventricles are relaxed and when the atria contract to pump blood into the ventricles. Figure $\PageIndex{14}$.b shows a frontal view. Although only the left side of the heart is illustrated, the process is virtually identical on the right.

Labeled diagrams of transverse and frontal sections of the heart showing that when the ventricles are relaxed the atrioventricular valves are open and the semilunar valves are closed.. — Figure $\PageIndex{14}$: Positions of Heart Valves during Ventricular Relaxation. (a) A transverse section through the heart illustrates the four heart valves. The two atrioventricular valves are open; the two semilunar valves are closed. The atria and vessels have been removed. (b) A frontal section through the heart illustrates blood flow through the mitral valve. When the mitral valve is open, it allows blood to move from the left atrium to the left ventricle. The aortic semilunar valve is closed to prevent backflow of blood from the aorta to the left ventricle. (Image credit: "Blood Flow Relaxed Ventricles" by OpenStax is licensed under CC BY 3.0)

Figure $\PageIndex{15}$.a shows the atrioventricular valves closed while the two semilunar valves are open. This occurs when the ventricles contract to eject blood into the pulmonary trunk and aorta. Closure of the two atrioventricular valves prevents blood from being forced back into the atria. This stage can be seen from a frontal view in Figure $\PageIndex{15}$.b.

Labeled diagrams of transverse and frontal sections of the heart showing that when the ventricles contract the atrioventricular valves are closed and the semilunar valves are open. — Figure $\PageIndex{15}$: Positions of Heart Valves during Ventricular Contraction. (a) A transverse section through the heart illustrates the four heart valves during ventricular contraction. The two atrioventricular valves are closed, but the two semilunar valves are open. The atria and vessels have been removed. (b) A frontal view shows the closed mitral (bicuspid) valve that prevents backflow of blood into the left atrium. The aortic semilunar valve is open to allow blood to be ejected into the aorta. (Image credit: "Blood Flow Contracted Ventricles" by OpenStax is licensed under CC BY 3.0)

INTERACTIVE LINK

Animation of cardiac cycle — Figure $\PageIndex{16}$: Echocardiogram of Heart Valves Opening and Closing. GIF-animation showing a moving echocardiogram; a 3D-loop of a heart viewed from the apex, with the apical part of the ventricles removed and the mitral valve clearly visible. Due to missing data the leaflet of the tricuspid and aortic valve is not clearly visible, but the openings are. To the left are two standard two-dimensional views taken from the 3D dataset. If not animated above, visit this site to observe an echocardiogram of actual heart valves opening and closing. (Image and caption credit: "Apikal4D" by Kjetil Lenes is licensed under CC BY-SA 3.0)

Although much of the heart has been “removed” from this gif loop so the chordae tendineae are not visible, why is their presence more critical for the atrioventricular valves (tricuspid and mitral) than the semilunar (aortic and pulmonary) valves?

Answer

The pressure gradient between the atria and the ventricles is much greater than that between the ventricles and the pulmonary trunk and aorta. Without the presence of the chordae tendineae and papillary muscles, the valves would be blown back (prolapsed) into the atria and blood would regurgitate.

Heart Sounds

One of the simplest, yet effective, diagnostic techniques applied to assess the state of a patient’s heart is auscultation using a stethoscope.

In a normal, healthy heart, there are only two audible heart sounds: S₁ and S₂. S₁ is the sound created by the closing of the atrioventricular valves during ventricular contraction and is normally described as a “lub,” or first heart sound. The second heart sound, S₂, is the sound of the closing of the semilunar valves during ventricular diastole and is described as a “dub” (Figure $\PageIndex{17}$). In both cases, as the valves close, the openings within the atrioventricular septum guarded by the valves will become reduced, and blood flow through the opening will become more turbulent until the valves are fully closed. There is a third heart sound, S₃, but it is rarely heard in healthy individuals. It may be the sound of blood flowing into the atria, or blood sloshing back and forth in the ventricle, or even tensing of the chordae tendineae. S₃ may be heard in youth, some athletes, and pregnant women. If the sound is heard later in life, it may indicate congestive heart failure, warranting further tests. Some cardiologists refer to the collective S₁, S₂, and S₃ sounds as the “Kentucky gallop,” because they mimic those produced by a galloping horse. The fourth heart sound, S₄, results from the contraction of the atria pushing blood into a stiff or hypertrophic ventricle, indicating failure of the left ventricle. S₄ occurs prior to S₁ and the collective sounds S₄, S₁, and S₂ are referred to by some cardiologists as the “Tennessee gallop,” because of their similarity to the sound produced by a galloping horse with a different gait. A few individuals may have both S₃and S₄, and this combined sound is referred to as S₇.

Graphical representation of time throughout a single cardiac cycle versus pressure in the atria and ventricles. The timing of the heart sounds upon valve closure are also shown along the time axis. — Figure $\PageIndex{17}$: Heart Sounds and the Cardiac Cycle. In this illustration, the x-axis reflects time with a recording of the heart sounds. The y-axis represents pressure. (Image credit: "Cardiac Cycle vs Heart Sounds" by OpenStax is licensed under CC BY 3.0)

The term murmur is used to describe an unusual sound coming from the heart that is caused by the turbulent flow of blood. Murmurs are graded on a scale of 1 to 6, with 1 being the most common, the most difficult sound to detect, and the least serious. The most severe is a 6. Phonocardiograms or auscultograms can be used to record both normal and abnormal sounds using specialized electronic stethoscopes.

During auscultation, it is common practice for the clinician to ask the patient to breathe deeply. This procedure not only allows for listening to airflow, but it may also amplify heart murmurs. Inhalation increases blood flow into the right side of the heart and may increase the amplitude of right-sided heart murmurs. Expiration partially restricts blood flow into the left side of the heart and may amplify left-sided heart murmurs. Placement of the stethoscope in four distinct locations enables optimal ausculation of each valve: near transition of the ascending aorta to the aortic arch for the aortic valve, near the bifurcation of the pulmonary trunk for the pulmonary valve, near the superior portion of the right ventricle for the tricuspid valve, and near the apex of the heart for the mitral valve. Figure $\PageIndex{18}$ indicates proper placement of the bell of the stethoscope to facilitate auscultation.

Stethoscope placement for optimal listening to each valve close is depicted. — Figure $\PageIndex{18}$: Stethoscope Placement for Auscultation. Proper placement of the bell of the stethoscope facilitates auscultation. At each of the four locations on the chest, a different valve can be heard. (Image credit: "Stethoscope Placement" by OpenStax is licensed under CC BY 3.0)

DISORDERS OF THE...

Heart Valves

When heart valves do not function properly, they are often described as incompetent and result in valvular heart disease, which can range from benign to lethal. Some of these conditions are congenital, that is, the individual was born with the defect, whereas others may be attributed to disease processes or trauma. Some malfunctions are treated with medications, others require surgery, and still others may be mild enough that the condition is merely monitored since treatment might trigger more serious consequences.

Valvular disorders are often caused by carditis, or inflammation of the heart. One common trigger for this inflammation is rheumatic fever, or scarlet fever, an autoimmune response to the presence of a bacterium, Streptococcus pyogenes, normally a disease of childhood.

While any of the heart valves may be involved in valve disorders, mitral regurgitation is the most common, detected in approximately 2 percent of the population, and the pulmonary semilunar valve is the least frequently involved. When a valve malfunctions, the flow of blood to a region will often be disrupted. The resulting inadequate flow of blood to this region will be described in general terms as an insufficiency. The specific type of insufficiency is named for the valve involved: aortic insufficiency, mitral insufficiency, tricuspid insufficiency, or pulmonary insufficiency.

If one of the cusps of the valve is forced backward by the force of the blood, the condition is referred to as a prolapsed valve. Prolapse may occur if the chordae tendineae are damaged or broken, causing the closure mechanism to fail. The failure of the valve to close properly disrupts the normal one-way flow of blood and results in regurgitation, when the blood flows backward from its normal path. Using a stethoscope, the disruption to the normal flow of blood produces a heart murmur.

Stenosis is a condition in which the heart valves become rigid and may calcify over time. The loss of flexibility of the valve interferes with normal function and may cause the heart to work harder to propel blood through the valve, which eventually weakens the heart. Aortic stenosis affects approximately 2 percent of the population over 65 years of age, and the percentage increases to approximately 4 percent in individuals over 85 years. Occasionally, one or more of the chordae tendineae will tear or the papillary muscle itself may die as a component of a myocardial infarction (heart attack). In this case, the patient’s condition will deteriorate dramatically and rapidly, and immediate surgical intervention may be required.

Auscultation, or listening to a patient’s heart sounds, is one of the most useful diagnostic tools, since it is proven, safe, and inexpensive. The term auscultation is derived from the Latin for “to listen,” and the technique has been used for diagnostic purposes as far back as the ancient Egyptians. Valve and septal disorders will trigger abnormal heart sounds. If a valvular disorder is detected or suspected, a test called an echocardiogram, or simply an “echo,” may be ordered. Echocardiograms are sonograms of the heart and can help in the diagnosis of valve disorders as well as a wide variety of heart pathologies.

CAREER CONNECTION

Cardiologist

Cardiologists are medical doctors that specialize in the diagnosis and treatment of diseases of the heart. After completing 4 years of medical school, cardiologists complete a three-year residency in internal medicine followed by an additional three or more years in cardiology. Following this 10-year period of medical training and clinical experience, they qualify for a rigorous two-day examination administered by the Board of Internal Medicine that tests their academic training and clinical abilities, including diagnostics and treatment. After successful completion of this examination, a physician becomes a board-certified cardiologist. Some board-certified cardiologists may be invited to become a Fellow of the American College of Cardiology (FACC). This professional recognition is awarded to outstanding physicians based upon merit, including outstanding credentials, achievements, and community contributions to cardiovascular medicine.

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CAREER CONNECTION

Cardiovascular Technologist/Technician

Cardiovascular technologists/technicians are trained professionals who perform a variety of imaging techniques, such as sonograms or echocardiograms, used by physicians to diagnose and treat diseases of the heart. Nearly all of these positions require an associate degree, and these technicians earn a median salary of $68,750 as of 2019. Growth within the field is fast, projected at 12 percent from 2019 - 2029, according to the U.S. Bureau of Labor Statistics.

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Visit this site for more information on cardiovascular technologists/technicians [statistics retrieved 10 Dec 2020].

There is a considerable overlap and complementary skills between cardiac technicians and vascular technicians, and so the term cardiovascular technician is often used. Special certifications within the field require documenting appropriate experience and completing additional and often expensive certification examinations. These subspecialties include Certified Rhythm Analysis Technician (CRAT), Certified Cardiographic Technician (CCT), Registered Congenital Cardiac Sonographer (RCCS), Registered Cardiac Electrophysiology Specialist (RCES), Registered Cardiovascular Invasive Specialist (RCIS), Registered Cardiac Sonographer (RCS), Registered Vascular Specialist (RVS), and Registered Phlebology Sonographer (RPhS).

Concept Review

The heart resides within the pericardial sac and is located in the mediastinal space within the thoracic cavity. The pericardial sac consists of two fused layers: an outer fibrous layer and an inner parietal pericardial serous membrane. Between the pericardial sac and the heart is the pericardial cavity, which is filled with lubricating serous fluid. The walls of the heart are composed of an outer epicardium, a thick myocardium, and an inner lining layer of endocardium. The human heart consists of a pair of atria, which receive blood and pump it into a pair of ventricles, which pump blood into the vessels. The right atrium receives systemic blood relatively low in oxygen and pumps it into the right ventricle, which pumps it into the pulmonary circuit. Exchange of oxygen and carbon dioxide occurs in the lungs, and blood high in oxygen returns to the left atrium, which pumps blood into the left ventricle, which in turn pumps blood into the aorta and the remainder of the systemic circuit. The septa are the partitions that separate the chambers of the heart. They include the interatrial septum, the interventricular septum, and the atrioventricular septum. Two of these openings are guarded by the atrioventricular valves, the right tricuspid valve and the left mitral valve, which prevent the backflow of blood. Each is attached to chordae tendineae that extend to the papillary muscles, which are extensions of the myocardium, to prevent the valves from being blown back into the atria. The pulmonary semilunar valve is located at the base of the pulmonary trunk, and the aortic semilunar valve is located at the base of the aorta.

Review Questions

Q. Which of the following is not important in preventing backflow of blood?

A. chordae tendineae

B. papillary muscles

C. AV valves

D. myocardium

Answer: D

Q. Which valve separates the left atrium from the left ventricle?

A. mitral

B. tricuspid

C. pulmonary

D. aortic

Answer: A

Q. Which of the following lists the valves in the order through which the blood flows from the vena cava through the heart?

A. tricuspid, pulmonary semilunar, bicuspid, aortic semilunar

B. mitral, pulmonary semilunar, bicuspid, aortic semilunar

C. aortic semilunar, pulmonary semilunar, tricuspid, bicuspid

D. bicuspid, aortic semilunar, tricuspid, pulmonary semilunar

Answer: A

Q. Which chamber initially receives blood from the systemic circuit?

A. left atrium

B. left ventricle

C. right atrium

D. right ventricle

Answer: C

Q. The myocardium would be the thickest in the ________.

A. left atrium

B. left ventricle

C. right atrium

D. right ventricle

Answer: B

Q. Most blood enters the ventricle during ________.

A. atrial systole

B. atrial diastole

C. ventricular systole

D. cardiac diastole

Answer: D

Q. The first heart sound represents which portion of the cardiac cycle?

A. atrial systole

B. ventricular systole

C. closing of the atrioventricular valves

D. closing of the semilunar valves

Answer: Answer: C

Q. In which septum is it normal to find openings in the adult?

A. interatrial septum

B. interventricular septum

C. atrioventricular septum

D. all of the above

Answer: C

Critical Thinking Questions

Q. Describe the cardiac cycle, beginning with both atria and ventricles relaxed.

Answer: A. The cardiac cycle comprises a complete relaxation and contraction of both the atria and ventricles, and lasts approximately 0.8 seconds. Beginning with all chambers in diastole, blood flows passively from the veins into the atria and past the atrioventricular valves into the ventricles. The atria begin to contract following depolarization of the atria and pump blood into the ventricles. The ventricles begin to contract, raising pressure within the ventricles. When ventricular pressure rises above the pressure in the two major arteries, blood pushes open the two semilunar valves and moves into the pulmonary trunk and aorta in the ventricular ejection phase. Following ventricular repolarization, the ventricles begin to relax, and pressure within the ventricles drops. When the pressure falls below that of the atria, blood moves from the atria into the ventricles, opening the atrioventricular valves and marking one complete heart cycle.

References

Axel L. “Papillary muscles do not attach directly to the solid heart wall.” Circulation. 2004 Jun 29;109(25):3145-8. doi: 10.1161/01.CIR.0000134276.06719.F3 [accessed 3 April 2021].

Gunnal, S A et al. “Study of mitral valve in human cadaveric hearts.” Heart views: the official journal of the Gulf Heart Association vol. 13,4 (2012): 132-5. doi:10.4103/1995-705X.105729 [accessed 3 April 2021].

Popa-Fotea, Nicoleta Monica et al. “Exploring the Continuum of Hypertrophic Cardiomyopathy-From DNA to Clinical Expression.” Medicina (Kaunas, Lithuania) vol. 55,6 299. 23 Jun. 2019, doi:10.3390/medicina55060299 [accessed 2 April 2021].

Glossary

anterior interventricular sulcus: sulcus located between the left and right ventricles on the anterior surface of the heart

aortic valve: (also, aortic semilunar valve) valve located at the base of the aorta

atrioventricular septum: cardiac septum located between the atria and ventricles; atrioventricular valves are located here

atrioventricular valves: one-way valves located between the atria and ventricles; the valve on the right is called the tricuspid valve, and the one on the left is the mitral or bicuspid valve

atrium: (plural = atria) upper or receiving chamber of the heart that pumps blood into the lower chambers just prior to their contraction; the right atrium receives blood from the systemic circuit that flows into the right ventricle; the left atrium receives blood from the pulmonary circuit that flows into the left ventricle

auricle: extension of an atrium visible on the anterosuperior surface of the heart

bicuspid valve: (also, mitral valve or left atrioventricular valve) valve located between the left atrium and ventricle; consists of two flaps of tissue

cardiac notch: depression in the medial surface of the inferior lobe of the left lung where the apex of the heart is located

cardiac skeleton: (also, skeleton of the heart) reinforced connective tissue located within the atrioventricular septum; includes four rings that surround the openings between the atria and ventricles, and the openings to the pulmonary trunk and aorta; the point of attachment for the heart valves

cardiomyocyte: muscle cell of the heart

chordae tendineae: string-like extensions of tough connective tissue that extend from the flaps of the atrioventricular valves to the papillary muscles

coronary arteries: branches of the ascending aorta that supply blood to the heart; the left coronary artery feeds the left side of the heart, the left atrium and ventricle, and the interventricular septum; the right coronary artery feeds the right atrium, portions of both ventricles, and the heart conduction system

coronary sinus: large, thin-walled vein on the posterior surface of the heart that lies within the atrioventricular sulcus and drains the heart myocardium directly into the right atrium

coronary sulcus: sulcus that marks the boundary between the atria and ventricles

endocardium: innermost layer of the heart lining the heart chambers and heart valves; composed of endothelium reinforced with a thin layer of connective tissue that binds to the myocardium

endothelium: layer of smooth, simple squamous epithelium that lines the endocardium and blood vessels

epicardium: innermost layer of the serous pericardium and the outermost layer of the heart wall

foramen ovale: opening in the fetal heart that allows blood to flow directly from the right atrium to the left atrium, bypassing the fetal pulmonary circuit

fossa ovalis: oval-shaped depression in the interatrial septum that marks the former location of the foramen ovale

hypertrophic cardiomyopathy: pathological enlargement of the heart, generally for no known reason

inferior vena cava: large systemic vein that returns blood to the heart from the inferior portion of the body

interatrial septum: cardiac septum located between the two atria; contains the fossa ovalis after birth

interventricular septum: cardiac septum located between the two ventricles

mitral valve: (also, left atrioventricular valve or bicuspid valve) valve located between the left atrium and ventricle; consists of two flaps of tissue

mesothelium: simple squamous epithelial portion of serous membranes, such as the superficial portion of the epicardium (the visceral pericardium) and the deepest portion of the pericardium (the parietal pericardium)

mitral valve: (also, left atrioventricular valve or bicuspid valve) valve located between the left atrium and ventricle; consists of two flaps of tissue

moderator band: band of myocardium covered by endocardium that arises from the inferior portion of the interventricular septum in the right ventricle and crosses to the anterior papillary muscle; contains conductile fibers that carry electrical signals followed by contraction of the heart

myocardium: thickest layer of the heart composed of cardiac muscle cells built upon a framework of primarily collagenous fibers and blood vessels that supply it and the nervous fibers that help to regulate it

papillary muscle: extension of the myocardium in the ventricles to which the chordae tendineae attach

pectinate muscles: muscular ridges seen on the anterior surface of the right atrium

pericardial cavity: cavity surrounding the heart filled with a lubricating serous fluid that reduces friction as the heart contracts

pericardial sac: (also, pericardium) membrane that separates the heart from other mediastinal structures; consists of two distinct, fused sublayers: the fibrous pericardium and the parietal pericardium

pericardium: (also, pericardial sac) membrane that separates the heart from other mediastinal structures; consists of two distinct, fused sublayers: the fibrous pericardium and the parietal pericardium

posterior interventricular sulcus: sulcus located between the left and right ventricles on the anterior surface of the heart

pulmonary arteries: left and right branches of the pulmonary trunk that carry deoxygenated blood from the heart to each of the lungs

pulmonary capillaries: capillaries surrounding the alveoli of the lungs where gas exchange occurs: carbon dioxide exits the blood and oxygen enters

pulmonary circuit: blood flow to and from the lungs

pulmonary trunk: large arterial vessel that carries blood ejected from the right ventricle; divides into the left and right pulmonary arteries

pulmonary valve: (also, pulmonary semilunar valve, the pulmonic valve, or the right semilunar valve) valve at the base of the pulmonary trunk that prevents backflow of blood into the right ventricle; consists of three flaps

pulmonary veins: veins that carry highly oxygenated blood into the left atrium, which pumps the blood into the left ventricle, which in turn pumps oxygenated blood into the aorta and to the many branches of the systemic circuit

right atrioventricular valve: (also, tricuspid valve) valve located between the right atrium and ventricle; consists of three flaps of tissue

semilunar valves: valves located at the base of the pulmonary trunk and at the base of the aorta

septum: (plural = septa) walls or partitions that divide the heart into chambers

septum primum: flap of tissue in the fetus that covers the foramen ovale within a few seconds after birth

sulcus: (plural = sulci) fat-filled groove visible on the surface of the heart; coronary vessels are also located in these areas

superior vena cava: large systemic vein that returns blood to the heart from the superior portion of the body

systemic circuit: blood flow to and from virtually all of the tissues of the body

trabeculae carneae: ridges of muscle covered by endocardium located in the ventricles

tricuspid valve: term used most often in clinical settings for the right atrioventricular valve

valve: in the cardiovascular system, a specialized structure located within the heart or vessels that ensures one-way flow of blood

ventricle: one of the primary pumping chambers of the heart located in the lower portion of the heart; the left ventricle is the major pumping chamber on the lower left side of the heart that ejects blood into the systemic circuit via the aorta and receives blood from the left atrium; the right ventricle is the major pumping chamber on the lower right side of the heart that ejects blood into the pulmonary circuit via the pulmonary trunk and receives blood from the right atrium

Contributors and Attributions

OpenStax Anatomy & Physiology (CC BY 4.0). Access for free at https://openstax.org/books/anatomy-and-physiology