17.2: Class I- Sodium Channel Blockers
By the end of this section, you should be able to:
- 17.2.1 Identify the characteristics of the sodium channel blocker drugs used to treat dysrhythmias.
- 17.2.2 Explain the indications, actions, adverse reactions, and interactions of the sodium channel blocker drugs used to treat dysrhythmias.
- 17.2.3 Describe the nursing implications of the sodium channel blocker drugs used to treat dysrhythmias.
- 17.2.4 Explain the client education related to the sodium channel blocker drugs used to treat dysrhythmias.
Class I antidysrhythmic drugs are known as sodium channel blockers. They block sodium channels in conduction tissue and myocytes. Sodium channels are responsible for the depolarization of cardiac cells, and blocking these channels leads to slower conduction and a longer refractory period between impulses. Class I antidysrhythmic drugs are further broken down into classes IA, IB, and IC.
Class IA drugs cause moderate blockade of sodium channels. They also have an additional mechanism of action and block potassium channels. Blockage of potassium channels leads to a property called proarrhythmia , meaning the drugs have a propensity to cause other arrhythmias. Drugs that block potassium channels prolong the QT interval, which increases the risk for torsade de pointes.
Class IB drugs block sodium channels with mild intensity. These drugs are exclusively used for ventricular arrhythmias.
Class IC drugs strongly block sodium channels but do not block potassium channels; thus, they are less proarrhythmic than class IA agents (King et al., 2023).
Various sodium channel antidysrhythmic drugs exist. This chapter will cover the following drugs in more detail: quinidine, procainamide, lidocaine, mexiletine, flecainide, and propafenone.
Quinidine
Quinidine is a class IA antidysrhythmic drug. It is available as an oral immediate-release tablet and an extended-release tablet. These tablets are different salt forms of quinidine; the immediate-release form is quinidine sulfate, and the extended-release form is quinidine gluconate. It is important to note that these are not interchangeable.
Quinidine is approved by the U.S. Food and Drug Administration (FDA) for cardioversion of atrial fibrillation and flutter to sinus rhythm and then for maintenance of sinus rhythm after cardioversion. It is also approved for suppression of recurrent ventricular arrhythmias.
Quinidine can easily be confused with quinine; nurses must be careful to avoid mixing up these drugs. Clients should be educated on the potential for diarrhea and contact their provider if this occurs because it can lead to electrolyte abnormalities that can exacerbate arrhythmias. Clients who take quinidine should avoid grapefruit and grapefruit juice because of potential interactions.
Procainamide
Procainamide is a class IA antidysrhythmic drug that is available only in an intravenous form. It is FDA approved for life-threatening ventricular arrhythmias but is used off-label for other arrhythmias as well, including atrial fibrillation. Procainamide is metabolized to N-acetyl procainamide, which is also active.
Lidocaine and Mexiletine
Lidocaine is a class IB antiarrhythmic drug. It has various uses as an anesthetic; however, in terms of dysrhythmias, it is used exclusively for treating ventricular arrhythmias. It can be used both for acute treatment of a primary arrhythmia and in advanced cardiac life support when clients have sudden cardiac arrest due to ventricular arrhythmias. When used for treating arrhythmias, lidocaine is administered only intravenously.
Clinical Tip
Lidocaine
Because lidocaine may cause central nervous system toxicity, the nurse should assess the client frequently. Signs and symptoms to watch for include sedation and irritability (twitching), which could progress to convulsions and respiratory depression/arrest.
Safety Alert
Lidocaine
Lidocaine is available in many formulations, some of which are not suitable for intravenous administration. Lidocaine with epinephrine is one such dosage form. The Institute for Safe Medication Practices reported a death that occurred when a client was administered topical lidocaine with epinephrine instead of the intravenous form of lidocaine with epinephrine, causing fatal cardiac arrhythmias. Lidocaine with epinephrine should never be used as an antidysrhythmic agent.
Mexiletine is like lidocaine in that it is a class IB drug. It is FDA approved for managing ventricular arrhythmias and is available as an oral capsule for long-term use.
Flecainide and Propafenone
Flecainide is a class IC antidysrhythmic drug that is available as an oral tablet. It is used for clients with paroxysmal symptomatic supraventricular tachycardias, including atrial fibrillation and atrial flutter. It can also be used for life-threatening ventricular tachyarrhythmias.
Propafenone is also a class IC drug. It is available as an oral immediate-release tablet and an oral extended-release capsule. It is FDA approved to treat life-threatening ventricular arrhythmias and to prolong time to recurrence of paroxysmal atrial fibrillation/flutter in clients without structural heart disease. Propafenone is used off-label in a technique informally called “pill in a pocket.” This technique refers to a scenario in which a client who has symptomatic recurrent paroxysmal atrial fibrillation can keep propafenone on hand and take it as needed when they detect symptoms of atrial fibrillation. The medication will convert them back to sinus rhythm without their needing to visit a health care provider. They do not take the medication daily, just when they need it.
Table 17.2 lists common class I antidysrhythmic drugs and typical routes and dosing for adult clients.
| Drug | Routes and Dosage Ranges |
|---|---|
| Quinidine |
Ventricular arrhythmias:
Quinidine sulfate: 200–600 mg every 6–12 hours. Quinidine gluconate: 324–648 mg every 8–12 hours. |
| Procainamide |
Ventricular arrhythmias:
Loading dose: 100 mg intravenously (IV) every 5 minutes, administered until the arrhythmia is suppressed or 500 mg has been administered. Maintenance dose: Typically 50 mcg/min/kg. |
|
Lidocaine
( Xylocaine ) |
Ventricular arrhythmias (hemodynamically stable): 1–1.5 mg/kg IV bolus, repeat 0.5–0.75 mg/kg IV bolus every 5–10 minutes; maintenance infusion is 1–4 mg/minute IV. |
| Mexiletine | Ventricular arrhythmias: 150–200 mg orally every 8–12 hours. |
| Flecainide | Maintenance of normal sinus rhythm in atrial fibrillation: 50–200 mg orally every 12 hours. |
|
Propafenone
( Rythmol SR ) |
Maintenance of normal sinus rhythm in atrial fibrillation:
Immediate release: 150–300 mg orally every 8 hours. Extended release: 225–425 mg orally every 12 hours. |
Adverse Effects and Contraindications
All sodium channel blockers have some propensity to cause heart blocks; however, the adverse effect profile of sodium channel blockers varies greatly depending on the drug.
Quinidine is associated with many serious risks. Trials have shown increased mortality risk compared with placebo and other antiarrhythmic drugs, and for this reason the drug has a boxed warning (DailyMed, Quinidine gluconate, 2021). Quinidine has a high incidence of diarrhea as an adverse effect (greater than 20%). It is hepatotoxic and has been associated with serious liver problems, including granulomatous hepatitis, so it should be used with caution in clients with hepatic impairment. It can be associated with thrombocytopenia and therefore should not be used in clients with baseline thrombocytopenia. In addition to acting as a sodium channel blocker, it blocks potassium channels and prolongs the QT interval, which leads to a proarrhythmic effect. The nurse will need to monitor the client’s ECG, complete blood count (CBC), and liver and kidney function.
Many serious risks associated with the use of procainamide have led to several boxed warnings. It has the potential to cause drug–induced lupus erythematosus–like syndrome as well as blood dyscrasias such as potentially fatal agranulocytosis, and it has been associated with increased mortality compared with placebo in certain populations. In addition to acting as a sodium channel blocker, it blocks potassium channels and prolongs the QT interval, which leads to a proarrhythmic effect. It should not be used in clients with certain heart blocks or in those with systemic lupus erythematosus or torsade de pointes. Procainamide can cause hypotension, so the nurse must be mindful of maximum infusion rates to minimize this possibility. The nurse will also need to monitor the client’s ECG, CBC, and drug levels of procainamide and its active metabolite, N-acetyl procainamide.
Lidocaine can cause central nervous system toxicity. The nurse will need to monitor the client’s ECG continuously and may need to monitor the client’s blood levels for the drug, depending on how long it will be administered.
Flecainide carries a warning because it can cause 1:1 AV conduction in atrial fibrillation/flutter. This means that the ventricles will beat once for each impulse in the atria, which is so fast that it can cause hemodynamic collapse. The nurse should monitor the client’s ECG and any blood levels ordered.
Contraindications vary based on the drug. Some of the most noteworthy contraindications include:
- Quinidine and procainamide should not be used in clients with baseline prolonged QT interval, given their effect on the QT interval. They also should not be used with other drugs that strongly prolong the QT interval. Procainamide is contraindicated in clients who have systemic lupus erythematosus.
- Lidocaine is contraindicated in individuals with an arrhythmia called Wolff–Parkinson–White syndrome and in those with certain heart blocks.
- Flecainide and propafenone are contraindicated in clients with structural heart disease, such as heart failure or myocardial infarction, due to potentially fatal proarrhythmic effects and worsening of heart failure.
Table 17.3 is a drug prototype table for sodium channel blockers featuring the class IB drug lidocaine. It lists drug class, mechanism of action, adult dosage, indications, therapeutic effects, drug and food interactions, adverse effects, and contraindications.
|
Drug Class
Sodium channel blocker Mechanism of Action Blocks sodium channels in the cells of the cardiac conduction system |
Drug Dosage
Ventricular arrhythmias (hemodynamically stable): 1–1.5 mg/kg IV bolus, repeat 0.5–0.75 mg/kg IV bolus every 5–10 minutes; maintenance infusion is 1–4 mg/minute IV. |
|
Indications
Acute treatment of ventricular cardiac arrhythmias Local and regional anesthesia Therapeutic Effects Facilitates cardioversion Maintains normal sinus rhythm |
Drug Interactions
Digoxin (toxicity) Beta-adrenergic blockers Food Interactions No significant interactions |
|
Adverse Effects
Bradycardia Hemodynamic collapse Atrioventricular block Sinus arrest Delirium Psychosis Seizure Nausea Tinnitus Dyspnea Bronchospasm |
Contraindications
Hypersensitivity Severe sinoatrial node disfunction, aortic stenosis, or intraventricular blocks |
Nursing Implications
The nurse should do the following for clients who are taking sodium channel blockers:
- Recognize and monitor for serious and potentially dangerous adverse effects of these drugs.
- Monitor the ECG of any client who takes antiarrhythmic drugs, paying careful attention to the QT interval.
- Monitor blood levels of drugs and relevant metabolites.
- Provide client teaching regarding the drug and when to call the health care provider. See below for client teaching guidelines.
Client Teaching Guidelines
The client taking quinidine should:
- Report excessive diarrhea to their health care provider.
The client taking mexiletine should:
- Report signs and symptoms of hepatic toxicity, such as jaundice.
The client taking propafenone should:
- Report signs of infection due to agranulocytosis, such as fever or sore throat.
FDA Black Box Warning
Quinidine
Active antiarrhythmic therapy has resulted in increased mortality; the risk of active therapy is greatest in clients with structural heart disease.
Procainamide
Prolonged administration of procainamide often leads to the development of a positive antinuclear antibody test, with or without symptoms of lupus erythematosus–like syndrome. If a positive antinuclear antibody titer develops, the benefits versus the risks of continued procainamide therapy should be assessed. In addition, agranulocytosis, bone marrow depression, neutropenia, hypoplastic anemia, and thrombocytopenia in clients receiving procainamide HCl have been reported at a rate of approximately 0.5%.
Mexiletine
In postmarketing experience, abnormal liver function tests have been reported, some in the first few weeks of therapy.
Flecainide
A review of the world literature revealed reports of ventricular tachycardia in 0.4% of clients receiving flecainide. Of 19 clients reported in the literature with chronic atrial fibrillation, 10.5% experienced ventricular tachycardia or ventricular fibrillation. Flecainide is not recommended for use in clients with chronic atrial fibrillation.
Flecainide, Propafenone, Mexiletine, Procainamide
In the CAST trial, there was excessive mortality in post–myocardial infarction clients who were administered flecainide or another similar drug, encainide.