7.6: Health Consequences of Too Little and Too Much Dietary Protein

A healthy diet incorporates all nutrients in moderation, meaning that there’s neither too little nor too much. As with all nutrients, having too little or too much protein can have health consequences.

The AMDR for protein for adults is between 10 and 35%  of kilocalories.¹ That’s a fairly wide range, encompassing typical protein intakes of many traditional human cultures.

Figure \(\PageIndex{1}\): Diverse human cultures have survived on different levels of dietary protein. The photo on the left shows Inuit families sharing frozen, aged walrus meat. Their traditional diet is very dependent on meat and high in both protein and fat. “Walrus meat” by Ansgar Walk is licensed under CC BY-SA 2.5. On the right is a traditional vegetarian meal in India, high in carbohydrates but still providing adequate levels of protein. “Vegetarian Curry” by GracinhaMarco Abundo is licensed under CC BY 2.0.

Protein intake below the RDA is inadequate to support the body’s needs for synthesizing structural and functional proteins. However, there are some concerns that high protein intake is associated with chronic disease. However, as we’ll discuss, it’s not just the quantity of protein that matters but also the nutritional package it comes in.

According to a 2018 study published in the American Journal of Clinical Nutrition, most Americans get enough protein, averaging about 88 grams per day and 14 to 16% of caloric intake. The study also found that diets with protein above 35 percent of caloric intake, the upper end of the AMDR, were extremely rare.²

Health Consequences of Protein Deficiency

Although severe protein deficiency is rare in the developed world, it is a leading cause of death in children in many poor, underdeveloped countries. Two main syndromes are associated with protein deficiencies: kwashiorkor and marasmus.

Kwashiorkor affects millions of children worldwide. When it was first described in 1935, more than 90% of children with kwashiorkor died. Although the associated mortality is slightly lower now, most children still die after the initiation of treatment.

The name kwashiorkor comes from a language in Ghana and means “rejected one.” The syndrome was named because it occurs most commonly in children recently weaned from breastfeeding, usually because the mother had a new baby and the older child was switched to a diet of watery porridge made from low-protein grains. The child may be consuming enough calories but not enough protein.

Kwashiorkor is characterized by swelling (edema) of the feet and abdomen, poor skin health, poor growth, low muscle mass, and liver malfunction. Recall that one role of protein in the body is fluid balance. Diets extremely low in protein do not provide enough amino acids for synthesizing the protein albumin. One of the functions of albumin is to hold water in the blood vessels, so having lower concentrations of blood albumin results in water moving out of the blood vessels and into tissues, causing swelling. The primary symptoms of Kwashiorkor include not only swelling but also diarrhea, fatigue, peeling skin, and irritability. Severe protein deficiency, in addition to other micronutrient deficiencies such as folate, iodine, iron, and vitamin C, all contribute to the many health manifestations of this syndrome.

Children and adults with marasmus are protein deficient, but at the same time, they’re also not taking in enough calories. Body weights of children with marasmus may be up to 80% less than that of a healthy child of the same age. Marasmus is a Greek word meaning “starvation.” The syndrome affects more than 50 million children under age 5 worldwide. It is characterized by an extreme emaciated appearance, poor skin health, poor growth, and an increased risk of infection. The symptoms are acute fatigue, hunger, and diarrhea.

Figure \(\PageIndex{2}\): Health consequences of protein deficiency. The photo on the left shows a child suffering from kwashiorkor (note the swollen belly) in the late 1960s in a Nigerian relief camp during the Nigerian-Biafran War. “Child with kwashiorkor” by Centers for Disease Control and Prevention is in the Public Domain. The photo on the right shows an Indian child suffering from marasmus. “Child with marasmus” by Centers for Disease Control and Prevention is in the Public Domain

Kwashiorkor and marasmus often coexist as a combined syndrome termed marasmic kwashiorkor. Children with the combined syndrome have variable amounts of edema and the characterizations and symptoms of marasmus. Although organ system function is compromised by undernutrition, the ultimate cause of death is usually infection. Undernutrition is intricately linked with suppression of the immune system at multiple levels, so undernourished children commonly die from severe diarrhea and/or pneumonia resulting from bacterial or viral infection. According to the United Nations Children’s Fund (UNICEF), nearly half of all deaths of children under age five are related to malnutrition.³ That translates to about 3 million child deaths each year.

While severe protein deficiency is rare in the US, several groups are at risk of low protein intake. A 2018 study found that 23% of US adolescent girls (aged 14 to 18 years old) and 11% of adolescent boys were consuming below the RDA for protein, which may compromise their growth and development.² This is thought to be related to the growing independence in food choices and the high prevalence of dieting in this group.

Low protein intake is also a concern for the elderly in the U.S. The same 2018 study found that among those 71 years and older, 19% of women and 13% of men consume less protein than the RDA.² This is a particular concern in this age group, as loss of muscle accelerates with aging, leading to greater frailty, loss of balance, and greater risk of falls. Some researchers argue that older adults actually need more protein than recommended by the RDA to maintain muscle mass and function.⁴

Health Consequences of Too Much Protein in the Diet

When the Food and Nutrition Board of the Institute of Medicine wrote the DRI for macronutrients, published in 2005, they concluded that there wasn’t enough evidence to establish an Upper Limit for protein. The high end of the AMDR, 35% of kilocalories for protein, was set to allow the total diet to be well-balanced with carbohydrates and fat.¹ Higher levels of protein intake haven’t been well-studied, but over the years, there have been many concerns with high-protein diets. However, current evidence indicates it’s large amounts of animal protein (particularly from red meat or processed meats) that can be problematic, not high amounts of protein per se.⁵

For example, a diet containing lots of steak, bacon, and sausage would be high in protein, but it also might be high in saturated fat, cholesterol, salt, and nitrates. Eating more red meat and processed red meat is linked to an increased risk of heart disease, stroke, and cancer (especially colorectal, stomach, pancreatic, prostate, and breast cancers). This link doesn’t seem to be caused by the protein but rather by the nutritional package that it comes in. In addition, the link to cancer may be related to the carcinogens that can form when meat is cooked at high temperatures, particularly when it’s charred by grilling.⁵

On the other hand, studies show that when protein comes from lean meat and plant sources, the risk of chronic diseases may be reduced. For example, a 2015 study found that frequent consumption of red meat in adolescence was associated with a higher risk of breast cancer later in life, whereas consuming poultry, fish, legumes, and nuts instead lowered the risk.⁶ Other studies have shown that higher protein diets can reduce the risk of heart disease, provided the protein comes from healthier sources.

Figure \(\PageIndex{3}\) . Compare several different “protein packages.” The steak and bacon provide protein but also large amounts of saturated fat and sodium. Salmon provides as much protein as the steak but with less saturated fat and more polyunsaturated fats. Lentils are a good source of protein, are low in fat, and are a great source of fiber. “Sirloin steak Outback Steakhouse March 13, 20112 ” by Steven Depolo is licensed under CC BY 2.0; “bacon” by Bradley Gordon is licensed under CC BY 2.0; “Wild Salmon Dinner” by Ketzirah Lesser and Art Drau is licensed under CC BY-SA 2.0; “ASCF1853 (lentils)” by Lucas Falcao is licensed under CC BY-NC-ND 2.0.

 Several other concerns about high protein diets haven’t turned out to be problematic after all:

• Osteoporosis – High protein diets were once thought to increase the risk of osteoporosis because researchers noticed that urinary calcium excretion increases when people consume high amounts of protein. However, a 2017 systematic review and meta-analysis from the National Osteoporosis Foundation found that this is not a concern, and some studies even show that higher protein intake is associated with greater bone mineral density.⁷
• Kidney function – Another concern was that high protein diets would strain the kidneys because of the increased need to filter and excrete nitrogen. A 2018 meta-analysis concluded that this is not a concern. However, people with chronic kidney disease should avoid high protein diets and maintain protein intake around the RDA of 0.8 g/kg, a lower intake than many Americans consume.⁸ A 2009 study tested a very low protein diet of 0.6 g/kg protein per day in people with chronic kidney disease and found that it did not prevent the development of kidney failure but did increase the risk of death, underscoring the importance of adequate protein even in people with kidney disease.⁹

From all of this research, there’s little evidence that a high protein diet is inherently harmful, so long as the protein doesn’t come packaged with a lot of saturated fat and red meat consumption is limited. Still, there’s little research directly testing the health effects of very high protein diets, including those achieved using protein supplements of purified protein, so it’s probably wise to keep protein balanced with the other macronutrients, focusing on whole foods from all the food groups.

Attributions:

• Lindshield, B. L. Kansas State University Human Nutrition (FNDH 400) Flexbook. goo.gl/vOAnR, CC BY-NC-SA 4.0
• “Diseases Involving Proteins," section 6.5 from the book An Introduction to Nutrition (v. 1.0), CC BY-NC-SA 3.0

References:

1. Trumbo P, Schlicker S, Yates AA, Poos M, Food and Nutrition Board, & Institute of Medicine, The National Academies. Dietary reference intakes for energy, carbohydrate, fiber, fat, fatty acids, cholesterol, protein, and amino acids. J Am Diet Assoc. 2002;102(11):1621-1630. doi:10.1016/s0002-8223(02)90346-9.
2. Berryman CE, Lieberman HR, Fulgoni VL, Pasiakos, SM. Protein intake trends and conformity with the Dietary Reference Intakes in the United States: analysis of the National Health and Nutrition Examination Survey, 2001-2014. Am. J. Clin. Nutr. 2018;108(2):405-413. doi.org/10.1093/ajcn/nqy088.
3. UNICEF. The State of the World’s Children 2019. Children, Food and Nutrition: Growing Well in a Changing World. Published October 2019. Accessed August 1, 2023. https://www.unicef.org/media/106506/file/The%20State%20of%20the%20World%E2%80%99s%20Children%202019.pdf.
4. Traylor DA, Gorissen SHM, Phillips SM. Perspective: protein requirements and optimal intakes in aging: are we ready to recommend more than the recommended daily allowance? Adv Nutr. 2018;9(3):171-182. doi.org/10.1093/advances/nmy003.
5. Protein. Harvard TH Chan School of Public Health. Accessed September 11, 2023. https://www.hsph.harvard.edu/nutritionsource/what-should-you-eat/protein/.
6. Farvid MS, Cho E, Chen WY, Eliassen AH, Willett WC. Adolescent meat intake and breast cancer risk. Int. J. of Cancer. 2015;136(8):1909–1920. doi.org/10.1002/ijc.29218.
7. Shams-White MM, Chung M, Du M, et al. Dietary protein and bone health: a systematic review and meta-analysis from the National Osteoporosis Foundation. Am J Clin Nutr. 2017;105(6):1528–1543. doi.org/10.3945/ajcn.116.145110.
8. Devries MC, Sithamparapillai A, Brimble KS, Banfield L, Morton RW, Phillips SM. Changes in kidney function do not differ between healthy adults consuming higher- compared with lower- or normal-protein diets: a systematic review and meta-analysis. J Nutr. 2018;148(11):1760–1775. doi.org/10.1093/jn/nxy197.
9. Menon V, Kopple JD, Wang X, et al. Effect of a very low-protein diet on outcomes: long-term follow-up of the Modification of Diet in Renal Disease (MDRD) Study. Amer J Kidney Dis. 2009;53(2):208–217. doi.org/10.1053/j.ajkd.2008.08.009.