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1.3: What Are Nutrients?

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    Learning Objective

    • Define the word “nutrient” and identify the six classes of nutrients essential for health.
    • List the three energy-yielding nutrients and their energy contribution.

    What is in Food?

    The foods we eat contain nutrients. Those nutrients that contain carbon are called organic while those that do not contain carbon are called inorganic. Nutrients are substances required by the body to perform its basic functions. Since the human body does not synthesize nutrients, they must be obtained from the diet, making them essential. Eating inadequate amounts can cause poor health.

    Nutrients are used to produce energy, detect and respond to environmental surroundings, move, excrete wastes, respire (breathe), grow, and reproduce. There are six classes of nutrients required for the body to function and maintain overall health. These are carbohydrates, lipids, proteins, water, vitamins, and minerals. Foods also contain nonnutrients that may be harmful (such as cholesterol, dyes, and preservatives) or beneficial (such as phytochemicals like antioxidants and zoochemicals like omega-3 fatty acids).

    Figure 1.3.1: The Six Classes of Nutrients. Source: http://www.chemistry.wustl.edu/~edudev/LabTutorials/Vitamins/vitamins.html.

    Macronutrients

    Nutrients that are needed in large amounts (grams) are called macronutrients. There are three classes of macronutrients: carbohydrates, lipids, and proteins. These can be metabolically processed into cellular energy. The energy from macronutrients comes from their chemical bonds. This chemical energy is converted into cellular energy that is then utilized to perform work, allowing our bodies to conduct their basic functions. A unit of measurement of food energy is the calorie. On nutrition food labels the amount given for “calories” is actually equivalent to each calorie multiplied by one thousand. A kilocalorie (one thousand calories, denoted with a small “c”) is synonymous with the “Calorie” (with a capital “C”) on nutrition food labels. Water is also a macronutrient in the sense that you require a large amount of it, but unlike the other macronutrients it does not yield calories.

    Carbohydrates

    Carbohydrates are molecules composed of carbon, hydrogen, and oxygen. The major food sources of carbohydrates are grains, milk, fruits, and vegetables, including starchy vegetables like potatoes. Nonstarchy vegetables also contain carbohydrates but in lesser quantities. Carbohydrates are broadly classified into two forms based on their chemical structure: fast-releasing carbohydrates often called simple sugars, and complex or slow-releasing carbohydrates also called polysacchrides.

    Fast-releasing carbohydrates consist of one or two basic units. Examples of simple sugars include sucrose, the type of sugar you would have in a bowl on the breakfast table, and glucose, the type of sugar that circulates in your blood.

    Figure 1.3.2: The Macronutrients: Carbohydrates, Lipids, Protein, and Water

    Slow-releasing or complex carbohydrates are long chains of simple sugars that can be branched or unbranched. Starch is an example of a slow-releasing carbohydrate. During digestion, the small intestine breaks down all slow-releasing carbohydrates to simple sugars, mostly glucose. Glucose is then absorbed and transported to all our cells where it is stored in the form of glycogen, used to make energy, or used to build macromolecules. Fiber is also a slow-releasing carbohydrate, but it cannot be broken down in the human body and passes through the digestive tract undigested unless the bacteria that inhabit the gut break it down.

    One gram of carbohydrates yields four kilocalories of energy for the cells in the body to perform work. In addition to providing energy and serving as building blocks for bigger macromolecules, carbohydrates are essential for proper functioning of the nervous system, heart, and kidneys. As mentioned, glucose can be stored in the body for future use. In humans, the storage molecule of carbohydrates is called glycogen and in plants, it is known as starches. Glycogen and starches are slow-releasing carbohydrates.

    Lipids

    Lipids are also a family of molecules composed of carbon, hydrogen, and oxygen, but unlike carbohydrates, they are insoluble in water. This class of molecules may be visible (for example vegetable oil)  or invisible (for example, cream)  in the food you eat. Lipids are found predominately in butter, oils, meats, dairy products, nuts, and seeds, and in many processed foods. The three main types of lipids are triglycerides (also called triacylglycerols), phospholipids, and sterols. The main job of lipids is to store energy. Lipids provide more energy per gram than carbohydrates (nine kilocalories per gram of lipids versus four kilocalories per gram of carbohydrates). In addition to energy storage, lipids serve as cell membranes, surround and protect organs, aid in temperature regulation, and regulate many other functions in the body. The main job of lipids is to store energy. Lipids provide more energy per gram than carbohydrates (nine kilocalories per gram of lipids versus four kilocalories per gram of carbohydrates). In addition to energy storage, lipids serve as cell membranes, surround and protect organs, aid in temperature regulation, and regulate many other functions in the body.

    Proteins

    Proteins are macromolecules composed of chains of subunits called amino acids which are the called the building blocks of protein. Amino acids are simple subunits composed of carbon, oxygen, hydrogen, and nitrogen. The food sources of protein come from animals such as meats, dairy products, seafood, and a variety of different plant-based foods, for example, soy, beans, and nuts. The word protein comes from a Greek word meaning “of primary importance,” which is an apt description of these macronutrients; they are also known colloquially as the “workhorses” of life. Proteins provide four kilocalories of energy per gram; however providing energy is not protein’s most important function. Proteins provide structure to bones, muscles, and skin, and play a role in conducting most of the chemical reactions that take place in the body. Scientists estimate that greater than one-hundred thousand different proteins exist within the human body.

    Water

    There is one other nutrient that we must have in large quantities: water. Water does not contain carbon, but is composed of two hydrogens and one oxygen per molecule of water. More than 60 percent of your total body weight is water. Without it, nothing could be transported in or out of the body, chemical reactions would not occur (acts as a solvent), organs would not be cushioned, joints would not be lubricated, and body temperature would fluctuate widely. On average, an adult consumes just over two liters of water per day from food and drink. According to the “rule of threes,” a generalization supported by survival experts, a person can survive three minutes without oxygen, three days without water, and three weeks without food. Since water is so critical for life’s basic processes, the amount of water input and output is supremely important, a topic we will explore in detail in Chapter 7.

    Micronutrients

    Micronutrients are nutrients required by the body in lesser amounts but are still essential for carrying out bodily functions. Micronutrients include all the essential minerals and vitamins. There are thirteen vitamins and sixteen essential minerals (See Table 1.3.1 and Table 1.3.2 for a complete list and their major functions). In contrast to carbohydrates, lipids, and proteins, micronutrients are not directly used for making energy, but they assist in the process as being part of enzymes (i.e., coenzymes). Enzymes are proteins that catalyze chemical reactions in the body and are involved in all aspects of body functions from producing energy to digesting nutrients to building macromolecules. Micronutrients play many roles in the body.

    Vitamins

    The thirteen vitamins are organic compounds (carbon-based) categorized as either water-soluble or fat-soluble. The water-soluble vitamins are vitamin C and all the B vitamins, which include thiamine, riboflavin, niacin, pantothenic acid, pyroxidine, biotin, folate, and cobalamin. The fat-soluble vitamins are A, D, E, and K. Vitamins are required to perform many functions in the body (regulatory and metabolic capacity) such as making red blood cells, synthesizing bone tissue, and playing a role in normal vision, nervous system function, and immune system function.  Some function in chemical reactions involved in the release of energy from carbohydrates, fat, protein, and alcohol.  Vitamins do not supply energy directly and are not structural; they enable chemical reactions to occur.

    Table 1.03.1: Vitamins and Their Major Functions
    Vitamins Major Functions
    Water-soluble
    B1 (thiamine) Coenzyme, energy metabolism assistance
    B2 (riboflavin) Coenzyme, energy metabolism assistance
    B3 (niacin) Coenzyme, energy metabolism assistance
    B5 (pantothenic acid) Coenzyme, energy metabolism assistance
    B6 (pyroxidine) Coenzyme, amino acid synthesis assistance
    Biotin Coenzyme
    Folate Coenzyme, essential for growth
    B12 (cobalamin) Coenzyme, red blood cell synthesis
    C Collagen synthesis, antioxidant
    Fat-soluble
    A Vision, reproduction, immune system function
    D Bone and teeth health maintenance, immune system function
    E Antioxidant, cell membrane protection
    K Bone and teeth health maintenance, blood clotting

    Vitamin deficiencies can cause severe health problems. For example, a deficiency in niacin causes a disease called pellagra, which was common in the early twentieth century in some parts of America. The common signs and symptoms of pellagra are known as the “4D’s—diarrhea, dermatitis, dementia, and death.” Until scientists found out that better diets relieved the signs and symptoms of pellagra, many people with the disease ended up in insane asylums awaiting death (Video 1.3.1). Other vitamins were also found to prevent certain disorders and diseases such as scurvy (vitamin C), night blindness (vitamin A), and rickets (vitamin D).

    Minerals

    Minerals are solid inorganic substances that form crystals and are classified depending on how much of them we need. Trace minerals, such as molybdenum, selenium, zinc, iron, and iodine, are only required in a few milligrams or less and macrominerals, such as calcium, magnesium, potassium, sodium, and phosphorus, are required in hundreds of milligrams. Minerals function in structural, regulatory, and metabolic capacities.  Building bone and teeth are an example of a structural function; while maintaining fluid balance, building bone tissue, synthesizing hormones, transmitting nerve impulses, contracting and relaxing muscles, and protecting against harmful free radicals are examples of regulatory and metabolic processes.  Minerals do not supply energy directly.

    Table 1.3.2: Minerals and Their Major Functions
    Minerals Major Functions
    Macro or Major Minerals (>100 mg/day)
    Sodium Fluid balance, nerve transmission, muscle contraction
    Chloride Fluid balance, stomach acid production
    Potassium Fluid balance, nerve transmission, muscle contraction
    Calcium Bone and teeth health maintenance, nerve transmission, muscle contraction, blood clotting
    Phosphorus Bone and teeth health maintenance, acid-base balance
    Magnesium Protein production, nerve transmission, muscle contraction
    Sulfur Protein production
    Microminerals or Trace (<100 mg/day)
    Iron Carries oxygen, assists in energy production
    Zinc Protein and DNA production, wound healing, growth, immune system function
    Iodine Thyroid hormone production, growth, metabolism
    Selenium Antioxidant
    Copper Coenzyme, iron metabolism
    Manganese Coenzyme
    Fluoride Bone and teeth health maintenance, tooth decay prevention
    Chromium Assists insulin in glucose metabolism
    Molybdenum Coenzyme
      Ultra Trace Minerals
    Nickel Coenzyme
    Aluminum Exact biological function unknown
    Silicon promotes bone and connective tissue health; exact biological function unknown
    Vanadium similar to phosphate; exact biological function unknown
    Arsenic Exact biological function unknown; may play a role in converting methionine to its active metabolites
    Boron Exact biological function unknown; may play a role in cell membrane characteristics and transmembrane signaling

    Video 1.3.1: This video provides a brief history of Dr. Joseph Goldberger’s discovery that pellagra was a diet-related disease.

    Food Energy and Food Quality

    Though this is only Chapter 1, you have already seen the words "Calories" and "Energy" used several times.  In everyday life, you have probably heard people talk about how many Calories they burned on the treadmill or how many Calories are listed on a bag of chips.  Calories are a measure of energy.  It takes quite a lot of Calories (energy) to keep us alive.  Even if a person is in a coma, they still burn approximately 1000 Calories of energy in order for their heart to beat, their blood to circulate, their lungs to breathe, etc... We burn even more calories when we exercise.  The carbohydrates, fats, and proteins we eat and drink provide calories for us (and alcohol as well if we choose to consume it).  Sometimes people refer to these nutrients as "energy yielding".  As you read above, carbohydrates provide 4 Calories for every gram we consume; proteins provide 4 Calories for every gram we consume; fats provide 9 Calories for every gram we consume and alcohol provides 7 Calories of energy for every gram we consume.  Vitamins, minerals, and water do not provide any calories, even though they are still essential nutrients.  Please watch the following Ted Ed video called "What is a Calorie" which will describe in more detail what a Calorie is and why you may want to know how many Calories you are consuming compared to how many you are burning each day.  

    Video 1.03.2: This video describes a calorie. We hear about calories all the time: How many calories are in this cookie? How many are burned by doing 100 jumping jacks, or long-distance running, or fidgeting? But what is a calorie, really? And how many of them do we actually need? Emma Bryce explains how a few different factors should go into determining the recommended amount for each person.

    One measurement of food quality is the amount of nutrients it contains relative to the amount of energy (Calories) it provides. High-quality foods are nutrient dense, meaning they contain lots of the nutrients relative to the amount of Calories they provide. Nutrient-dense foods are the opposite of “empty-calorie” foods such as carbonated sugary soft drinks, which provide many calories and very little, if any, other nutrients. Food quality is additionally associated with its taste, texture, appearance, microbial content, and how much consumers like it. The quantity of nutrients present in foods can be influenced by farming conditions, ripeness of plants when harvested, cooking processes, and length of time it is stored.

    Food: A Better Source of Nutrients

    It is better to get all your micronutrients from the foods you eat as opposed to from supplements. Supplements contain only what is listed on the label, but foods contain many more macronutrients, micronutrients, and other chemicals, like antioxidants that benefit health. While vitamins, multivitamins, and supplements are a $20 billion industry in this country and more than 50 percent of Americans purchase and use them daily, there is no consistent evidence that they are better than food in promoting health and preventing disease. Dr. Marian Neuhouser, associate of the Fred Hutchinson Cancer Research Center in Seattle, says that “…scientific data are lacking on the long-term health benefits of supplements. To our surprise, we found that multivitamins did not lower the risk of the most common cancers and also had no impact on heart disease.”Woodward, K. “Multivitamins Each Day Will Not Keep Common Cancers Away; Largest Study of Its Kind Provides Definitive Evidence that Multivitamins Will Not Reduce Risk of Cancer or Heart Disease in Postmenopausal Women.” Fred Hutchinson Cancer Research Center. Center News 16 (February 2009). http://www.fhcrc.org/about/pubs/center_news/online/2009/02/multivitamin_study.html

    Key Takeaways

    • Foods contain nutrients that are essential for our bodies to function.
    • Four of the nutrient classes required for bodily function are needed in large amounts. They are carbohydrates, lipids, proteins, and water, and are referred to as macronutrients.
    • Two of the classes of nutrients are needed in lesser amounts but are still essential for bodily function. They are vitamins and minerals.
    • One measurement of food quality is the amount of essential nutrients a food contains relative to the amount of energy it has (nutrient density).

    Discussion Starters

    1. Make a list of some of your favorite foods and visit the “What’s In the Foods You Eat?” search tool provided by the USDA. What are some of the nutrients found in your favorite foods?

      http://www.ars.usda.gov/Services/docs.htm?docid=17032

    2. Have a discussion in class on the “progression of science” and its significance to human health as depicted in the video on pellagra (Video 1.3.1).