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6.2: Cofactors

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    1479
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    A number of enzymes require cofactors to function. Some also require what other textbooks and resources refer to as coenzymes. But to keep things simple, we are going to include these coenzymes in our definition of cofactors. Thus, cofactors can be either organic or inorganic molecules that are required by enzymes to function. Many organic cofactors are vitamins or molecules derived from vitamins. Most inorganic cofactors are minerals. Cofactors can be oxidized or reduced for the enzymes to catalyze the reactions.

    Two common cofactors that are derived from the B vitamins, niacin and riboflavin, are nicotinamide adenine dinucleotide (NAD) and flavin adenine dinucleotide (FAD), respectively. The structure of NAD and FAD are shown below.

    Figure 6.111 .png

    Figure 6.111 Structure of NAD1 upside down. The atoms are circled to help orient this structure with Figure 6.113

    Figure 6.112 .png

    Figure 6.112 Structure of FAD2. The nitrogens are circled to help orient this structure with Figure 6.114

    Both of these cofactors can be reduced; NAD is reduced to form NADH, while FAD is reduced to form FADH2 as shown in the 2 figures below.

    Figure 6.113.png

    Figure 6.113 The reduction of NAD to form NADH3

    Figure 6.114 .png

    Figure 6.114 The reduction of FAD4 to FADH2

    An example of a mineral that serves as a cofactor is Fe2+ for proline and lysyl hydroxylases. We will discuss later in detail why vitamin C (ascorbic acid) is needed to reduce iron to Fe2+ so that it can serve as a cofactor for proline and lysyl hydroxylases.

    Figure 6.115.png

    Figure 6.115 Iron (Fe2+) is a cofactor for proline and lysyl hydroxylases

    References & Links

    1. en.Wikipedia.org/wiki/File:NAD%2B_phys.svg
    2. en.Wikipedia.org/wiki/File:Fl...nucleotide.png
    3. en.Wikipedia.org/wiki/File:NA..._reduction.svg
    4. en.Wikipedia.org/wiki/File:FA...equlibrium.png

    This page titled 6.2: Cofactors is shared under a CC BY-NC-SA 4.0 license and was authored, remixed, and/or curated by Brian Lindshield via source content that was edited to the style and standards of the LibreTexts platform; a detailed edit history is available upon request.

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