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3.4C: Protein Digestion in the Small Intestine

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    1463
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    The small intestine is the major site of protein digestion by proteases (enzymes that cleave proteins). The pancreas secretes a number of proteases as zymogens into the duodenum where they must be activated before they can cleave peptide bonds1. This activation occurs through an activation cascade. A cascade is a series of reactions in which one step activates the next in a sequence that results in an amplification of the response. An example of a cascade is shown below.

    Figure 3.431.png

    Figure 3.431 An example of a cascade, with one event leading to many more events

    In this example, A activates B, B activates C, D, and E, C activates F and G, D activates H and I, and E activates K and L. Cascades also help to serve as control points for certain process. In the protease cascade, the activation of B is really important because it starts the cascade.

    The protease/colipase activation scheme starts with the enzyme enteropeptidase (secreted from the intestinal brush border) that converts trypsinogen to trypsin. Trypsin can activate all the proteases (including itself) and colipase (involved in fat digestion)1 as shown in the 2 figures below.


    Figure 3.432.png

    Figure 3.432 Protease/colipase activation cascade

    Figure 3.433 .png

    Figure 3.433 The protease/colipase activation cascade

    The products of the action of the proteases on proteins are dipeptides, tripeptides, and individual amino acids, as shown below.

    Figure 3.434.png

    Figure 3.434 Products of pancreatic proteases

    At the brush border, much like disaccharidases, there are peptidases that cleave some peptides down to amino acids. Not all peptides are cleaved to individual amino acid, because small peptides can be taken up into the enterocyte, thus, the peptides do not need to be completely broken down to individual amino acids. Thus the end products of protein digestion are primarily dipeptides and tripeptides, along with individual amino acids1.

    Figure 3.435 .png

    Figure 3.435 Peptidases are produced by the brush border to cleave some peptides into amino acids

    References & Links

    1. Gropper SS, Smith JL, Groff JL. (2008) Advanced nutrition and human metabolism. Belmont, CA: Wadsworth Publishing.

    This page titled 3.4C: Protein Digestion in the Small Intestine is shared under a CC BY-NC-SA 4.0 license and was authored, remixed, and/or curated by Brian Lindshield via source content that was edited to the style and standards of the LibreTexts platform; a detailed edit history is available upon request.

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