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12.5: Vitamin K

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    There are 3 forms of vitamin K. Phylloquinone (K1), the plant form of vitamin K, is the primary dietary form of vitamin K. Its structure is shown below.

    Figure 12.51.png

    Figure 12.51 Structure of phylloquinone (K1), the 3 outside of the brackets indicates that the structural unit inside the brackets is repeated 3 times1

    Green leafy vegetables, broccoli, Brussels sprouts, and asparagus are foods that are good sources of phylloquinone2.

    Another form of vitamin K, menaquinone (K2), is synthesized by bacteria in the colon. Menaquinone comprises ~10% of absorbed vitamin K every day and can also be found in small amounts in animal products. Its structure is shown below3.

    Figure 12.52.png

    Figure 12.52 Structure of menaquinone (K2). Menaquinones have side chains of varying length4

    In the structure above, if it was menaquinone-8, there would be 7 (8-1) repeating units of the structure inside the brackets above.

    The synthetic form of vitamin K is menadione (K3), whose structure is shown below.

    Figure 12.53.png

    Figure 12.53 Structure of menadione (K3)5

    A tail, similar to the one found in menaquinone, has to be added to menadione for it to be biologically active.

    Vitamin K is absorbed like other fat-soluble substances. Approximately 80% of phylloquinone and menaquinone are incorporated into chylomicrons and stored primarily in the liver2,6. Once metabolized, vitamin K is primarily excreted via bile in the feces, with a lesser amount excreted in urine6.

    References & Links


    2. McGuire M, Beerman KA. (2011) Nutritional sciences: From fundamentals to food. Belmont, CA: Wadsworth Cengage Learning.

    3. Byrd-Bredbenner C, Moe G, Beshgetoor D, Berning J. (2009) Wardlaw's perspectives in nutrition. New York, NY: McGraw-Hill.



    6. Gropper SS, Smith JL, Groff JL. (2008) Advanced nutrition and human metabolism. Belmont, CA: Wadsworth Publishing.

    This page titled 12.5: Vitamin K is shared under a CC BY-NC-SA 4.0 license and was authored, remixed, and/or curated by Brian Lindshield via source content that was edited to the style and standards of the LibreTexts platform; a detailed edit history is available upon request.

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