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7.1: Integration of Macronutrient & Alcohol Metabolic Pathways

If you were to draw all the macronutrient and alcohol metabolic pathways covered in chapter 6, hopefully it would look something like the figure below. In this figure:

Carbohydrate pathways are orange

Triglyceride/fatty acid pathways are purple

Protein/amino acid pathways are green

Nonclassified pathways are gray

Figure 7.11 Integrated macronutrient and alcohol metabolism1

To simplify, we are going to remove the glycerol and cholesterol pathways so that we can focus on integrating the other pathways in macronutrient and alcohol metabolism.

Figure 7.12 Removal of glycerol and cholesterol pathways1

Thus, we are left with the following simplified figure:

Figure 7.13 Simplified integrated macronutrient and alcohol metabolism1

Notice that acetyl-CoA is the central metabolite in integrated metabolism that connects many different pathways. For example, carbohydrates can be broken down to acetyl-CoA that can then be used to synthesize fats and ultimately triglycerides.