Search
- Filter Results
- Location
- Classification
- Include attachments
- https://med.libretexts.org/Bookshelves/Pharmacology_and_Neuroscience/Neuroscience_(Ju)/03%3A_Fundamental_Neuroscience_Techniques/3.07%3A_A_Very_Interesting_Transgenic_Mouse_for_NeuroscienceIf Cre-recombinase was introduced by vector injection then the STOP codon is removed and the DTR is now transcribed and translated in the area or tissue where the Cre-recombinase was injected. However...If Cre-recombinase was introduced by vector injection then the STOP codon is removed and the DTR is now transcribed and translated in the area or tissue where the Cre-recombinase was injected. However, when a vector is injected into the mouse, the LoxPs excise the STOP codon and thus DTR is able to be transcribed and translated in the tissue where Cre-recombinase was injected.
- https://med.libretexts.org/Bookshelves/Pharmacology_and_Neuroscience/Neuroscience_(Ju)/04%3A_Emergent_Topics_in_Neuroscience/4.02%3A_Gut_Microbiome_and_the_BrainThere are several ways in which the gut microbiota interacts with the brain. Components of bacteria, such as lipopolysaccharides, activate the innate immune system. In dysbiosis, the innate immune sys...There are several ways in which the gut microbiota interacts with the brain. Components of bacteria, such as lipopolysaccharides, activate the innate immune system. In dysbiosis, the innate immune system is overactive, which may result in inflammation of the central nervous system. Certain bacterially-derived metabolites, such as D-lactic acid and ammonia, have also been found to have neurotoxic effects. Many gut bacteria interact with the brain through the production of neurotransmitters.
- https://med.libretexts.org/Bookshelves/Pharmacology_and_Neuroscience/Neuroscience_(Ju)/02%3A_Neurodegeneration/2.04%3A_Chronic_Neurodegenerative_DiseasesAgain, there are many similarities with Multiple Sclerosis, and there is no known cure for Parkinson’s Disease and the disease remains idiopathic although there are some known causes of Parkinson’s Di...Again, there are many similarities with Multiple Sclerosis, and there is no known cure for Parkinson’s Disease and the disease remains idiopathic although there are some known causes of Parkinson’s Disease including loss of movement following cerebral atherosclerosis, viral encephalitis, and as the result of side effects from drugs such as phenothiazides and reserpine.
- https://med.libretexts.org/Bookshelves/Pharmacology_and_Neuroscience/Neuroscience_(Ju)/00%3A_Front_Matter
- https://med.libretexts.org/Bookshelves/Pharmacology_and_Neuroscience/Neuroscience_(Ju)/03%3A_Fundamental_Neuroscience_Techniques/3.06%3A_Viral_Mediated_Delivery_of_Genes_to_NeuronsSome viruses for example package only a small amount of genetic material (AAV for example) while others like HSV will be able to package up to 150 kb worth of genetic material (and this is a lot) into...Some viruses for example package only a small amount of genetic material (AAV for example) while others like HSV will be able to package up to 150 kb worth of genetic material (and this is a lot) into the virus. To produce lentiviruses with the gene of interest as the lentiviral DNA construct, first transfect cells with a packaging plasmid and the envelope vector (VSVG).Adeno Associated Virus (AAV) (lower panel) – Member of the parvoviridae family (20 nm diameter).
- https://med.libretexts.org/Bookshelves/Pharmacology_and_Neuroscience/Neuroscience_(Ju)/02%3A_Neurodegeneration/2.01%3A_Acute_Physical_Damage_to_the_Nervous_SystemThe previous chapter dealt with the impact that micro-organisms had on the health of neurons. This chapter outlines the differing roles of the PNS and CNS following injury and in recovery. It has long...The previous chapter dealt with the impact that micro-organisms had on the health of neurons. This chapter outlines the differing roles of the PNS and CNS following injury and in recovery. It has long been known that following damage to axons, that the neurons within the PNS can undergo outgrowth and can recover (i.e. undergo regeneration) while neurons within the CNS do not seem capable of doing so.
- https://med.libretexts.org/Bookshelves/Pharmacology_and_Neuroscience/Neuroscience_(Ju)/04%3A_Emergent_Topics_in_Neuroscience/4.04%3A_Integrative_and_Contemplative_NeuroscienceA new field of scientific study, contemplative science, is concerned with how training the mind through meditation can induce neuroplasticity. In this chapter, we explore how contemplative practices, ...A new field of scientific study, contemplative science, is concerned with how training the mind through meditation can induce neuroplasticity. In this chapter, we explore how contemplative practices, such as mindfulness meditation, influence neural activity and the architecture of the brain. Contemplative practices involve training a complex array of cognitive processing, including attentional and emotional regulation. In this chapter, we will take a closer look at this methodology.
- https://med.libretexts.org/Bookshelves/Pharmacology_and_Neuroscience/Neuroscience_(Ju)/04%3A_Emergent_Topics_in_Neuroscience/4.01%3A_The_Gut_Microbiome_and_its_Impact_on_the_BrainSpecifically, within all fields of biology there is an emerging theme that an organ (such as skin) can be colonized by different types of microbes and this colonization does not have to be homogeneous...Specifically, within all fields of biology there is an emerging theme that an organ (such as skin) can be colonized by different types of microbes and this colonization does not have to be homogeneous across a particular organ. Although many of these gut bacteria can be treated pharmacologically in order for them to be eliminated, this may not be always be the best treatment.
- https://med.libretexts.org/Bookshelves/Pharmacology_and_Neuroscience/Neuroscience_(Ju)/03%3A_Fundamental_Neuroscience_Techniques/3.02%3A_Patch-Clamp_ElectrophysiologyThe most common method used to assess ion-channel function is known as the patch-clamp electrophysiological technique that was developed in the 1970s by Nobel Prize Laureates Erwin Neher and Bert Sakm...The most common method used to assess ion-channel function is known as the patch-clamp electrophysiological technique that was developed in the 1970s by Nobel Prize Laureates Erwin Neher and Bert Sakmann. The patch-clamp technique allows a researcher to measure the biophysical properties of ion-channels on millisecond timescales.
- https://med.libretexts.org/Bookshelves/Pharmacology_and_Neuroscience/Neuroscience_(Ju)/03%3A_Fundamental_Neuroscience_Techniques
- https://med.libretexts.org/Bookshelves/Pharmacology_and_Neuroscience/Neuroscience_(Ju)/02%3A_Neurodegeneration/2.02%3A_Stroke_and_Loss_of_Blood_Flow_as_an_Acute_Injury_to_the_BrainThis ischemia that underlies stroke can occur in 2 different ways, hemorrhage: release of blood from blood vessels after the vessel rupture causes damage by cutting off connecting pathways, resulting ...This ischemia that underlies stroke can occur in 2 different ways, hemorrhage: release of blood from blood vessels after the vessel rupture causes damage by cutting off connecting pathways, resulting in local or generalized pressure injury as well as impaired blood flow to the brain, and blocking a blood vessel causing a lack of blood flow to that region of the brain as shown in Figure \(\PageIndex{1}\).
