The mesenchyme between these developing bones becomes the fibrous connective tissue of the suture joints between the bones in these regions of the skull. Starting during the sixth week, as each limb b...The mesenchyme between these developing bones becomes the fibrous connective tissue of the suture joints between the bones in these regions of the skull. Starting during the sixth week, as each limb bud continues to grow and elongate, areas of mesenchyme within the bud begin to differentiate into the hyaline cartilage that will form models for of each of the future bones.