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- https://med.libretexts.org/Bookshelves/Nutrition/Principles_of_Nutritional_Assessment_3e_(Gibson_et_al.)/27%3A_Copper_(Chapter_24b)/27.06%3A_Skin_lysyl_oxidase_(24b.5)This page discusses lysyl oxidase, a copper-dependent enzyme essential for collagen maturation and connective tissue health. Copper deficiency impairs its activity, causing skeletal and cardiac proble...This page discusses lysyl oxidase, a copper-dependent enzyme essential for collagen maturation and connective tissue health. Copper deficiency impairs its activity, causing skeletal and cardiac problems. A study showed that skin lysyl oxidase activity decreased in healthy males on a low copper diet but returned to normal after copper repletion.
- https://med.libretexts.org/Bookshelves/Nutrition/Principles_of_Nutritional_Assessment_3e_(Gibson_et_al.)/27%3A_Copper_(Chapter_24b)/27.04%3A_Erythrocyte_superoxide_dismutase_(24b.3)This page discusses the role of erythrocyte superoxide dismutase (Cu,Zn-SOD) in mitigating oxidative damage and its association with copper status. It highlights that while Cu,Zn-SOD activity can indi...This page discusses the role of erythrocyte superoxide dismutase (Cu,Zn-SOD) in mitigating oxidative damage and its association with copper status. It highlights that while Cu,Zn-SOD activity can indicate copper deficiency, responses to supplementation vary due to factors like duration and cell turnover. Current reference ranges for SOD activity are not standardized, though they appear stable across demographics, except for a noted decrease in younger individuals.
- https://med.libretexts.org/Bookshelves/Nutrition/Principles_of_Nutritional_Assessment_3e_(Gibson_et_al.)/27%3A_Copper_(Chapter_24b)/27.08%3A_Copper_chaperones_(24b.7)This page explores the role of copper in cells, highlighting the binding of copper to chaperones like ATX1 and the significance of CCS as an indicator of copper status linked to dietary intake. The CC...This page explores the role of copper in cells, highlighting the binding of copper to chaperones like ATX1 and the significance of CCS as an indicator of copper status linked to dietary intake. The CCS:SOD1 ratio is noted for its sensitivity in assessing copper levels. Additionally, research suggests that CCS maintains stable levels during inflammation, contrasting with ceruloplasmin, which may establish CCS as a reliable clinical copper marker.
- https://med.libretexts.org/Bookshelves/Nutrition/Principles_of_Nutritional_Assessment_3e_(Gibson_et_al.)/27%3A_Copper_(Chapter_24b)This page emphasizes the significance of copper for human health, covering its metabolism, dietary sources, and recommended amounts. It addresses the impacts of copper deficiency and excess, the compl...This page emphasizes the significance of copper for human health, covering its metabolism, dietary sources, and recommended amounts. It addresses the impacts of copper deficiency and excess, the complexity of evaluating copper status through serum levels and ceruloplasmin, and introduces potential markers like cuproenzymes and chaperones, which pose measurement difficulties. External factors affecting these indicators further complicate assessments of copper status.
- https://med.libretexts.org/Bookshelves/Nutrition/Principles_of_Nutritional_Assessment_3e_(Gibson_et_al.)/27%3A_Copper_(Chapter_24b)/27.02%3A_Serum_copper_(24b.1)This page explains the complexity of serum copper levels, highlighting that they exist in two forms and can be influenced by various factors including age, gender, and health conditions. Low serum cop...This page explains the complexity of serum copper levels, highlighting that they exist in two forms and can be influenced by various factors including age, gender, and health conditions. Low serum copper indicates severe deficiency but is unreliable for marginal status. Influencing factors such as diurnal cycles, infections, and certain diseases can lead to variability in serum copper concentrations.
- https://med.libretexts.org/Bookshelves/Veterinary_Medicine/A_Guide_to_the_Principles_of_Animal_Nutrition_(Cherian)/01%3A_Chapters/1.16%3A_XVI._MicromineralsThis chapter provides an introduction and discussion of different microminerals that are important in the nutrition of food-producing animals.
- https://med.libretexts.org/Bookshelves/Nutrition/Principles_of_Nutritional_Assessment_3e_(Gibson_et_al.)/27%3A_Copper_(Chapter_24b)/27.09%3A_Other_indices_of_copper_status_(24b.8)This page discusses the correlation of hair copper concentrations with organ levels in rats, noting their unreliability as human biomarkers, especially for copper-related conditions. Gender and age af...This page discusses the correlation of hair copper concentrations with organ levels in rats, noting their unreliability as human biomarkers, especially for copper-related conditions. Gender and age affect hair copper levels significantly. Urinary copper is seldom useful for assessment, and there is limited data on copper in erythrocytes and fingernails. Serum copper is commonly used, but methods like Cu,Zn-SOD activity may offer better insights.
- https://med.libretexts.org/Bookshelves/Nutrition/Principles_of_Nutritional_Assessment_3e_(Gibson_et_al.)/27%3A_Copper_(Chapter_24b)/27.01%3A_Copper_(24b.0)This page discusses the importance of copper in the human body, highlighting its role in enzyme functions and the potential health impacts of deficiency, such as anemia and neurological issues. While ...This page discusses the importance of copper in the human body, highlighting its role in enzyme functions and the potential health impacts of deficiency, such as anemia and neurological issues. While deficiencies are rare, they can arise from poor diet or malabsorption. Copper is primarily absorbed in the small intestine, and dietary sources include shellfish and nuts.
- https://med.libretexts.org/Bookshelves/Nutrition/Principles_of_Nutritional_Assessment_3e_(Gibson_et_al.)/27%3A_Copper_(Chapter_24b)/27.03%3A_Serum_ceruloplasmin_(24b.2)This page discusses ceruloplasmin, a vital copper-carrying protein synthesized in the liver, integral to copper and iron transport. Its levels are influenced by factors like age, gender, estrogen, and...This page discusses ceruloplasmin, a vital copper-carrying protein synthesized in the liver, integral to copper and iron transport. Its levels are influenced by factors like age, gender, estrogen, and inflammation, making it unreliable as a copper status marker except in severe cases. Measurement techniques vary, and recent insights suggest that the enzymatic activity-to-protein concentration ratio might more accurately convey copper status than conventional methods.
