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9.03: Diffusion and Transportation of Oxygen

Diagram 9.2: Cross section of an alveolus

The air in the alveoli is rich in oxygen while the blood in the capillaries around the alveoli is deoxygenated. This is because the haemoglobin in the red blood cells has released all the oxygen it has been carrying to the cells of the body. Oxygen diffuses from high concentration to low concentration. It therefore crosses the narrow barrier between the alveoli and the capillaries to enter the blood and combine with the haemoglobin in the red blood cells to form oxyhaemoglobin.

The narrow diameter of the capillaries around the alveoli means that the blood flow is slowed down and that the red cells are squeezed against the capillary walls. Both of these factors help the oxygen diffuse into the blood (see diagram 9.2).

When the blood reaches the capillaries of the tissues the oxygen splits from the haemoglobin molecule. It then diffuses into the tissue fluid and then into the cells.


  • Ruth Lawson (Otago Polytechnic; Dunedin, New Zealand)