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3.8: Pappenheimer Bodies (Siderotic Granules)

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    Appearance:

    Inclusions are visible under both Wright/Romanowsky stains and Perls Prussian Blue stain. Pappenheimer inclusions appear as clusters of fine and irregular granules located at the periphery of the red blood cell.1-3

    Inclusion composition:3

    Iron

    Associated Disease/Clinical States:1,2

    Splenectomy

    Sideroblastic Anemia

    Thalassemia

    Sickle Cell Disease

    Hemachromatosis

    References:

    1. Landis-Piwowar K, Landis J, Keila P. The complete blood count and peripheral blood smear evaluation. In: Clinical laboratory hematology. 3rd ed. New Jersey: Pearson; 2015. p. 154-77.

    2. Jones KW. Evaluation of cell morphology and introduction to platelet and white blood cell morphology. In: Clinical hematology and fundamentals of hemostasis. 5th ed. Philadelphia: F.A. Davis Company; 2009. p. 93-116.

    3. Rodak BF, Carr JH. Inclusions in erythrocytes. In: Clinical hematology atlas. 5th ed. St. Louis, Missouri: Elsevier Inc.; 2017. p. 107-14.

    This page titled 3.8: Pappenheimer Bodies (Siderotic Granules) was last modified on Sat, 02 Sep 2023 08:16:24 GMT and is shared under a CC BY-NC 4.0 license and was authored, remixed, and/or curated by Valentin Villatoro and Michelle To (Open Education Alberta) via source content that was edited to the style and standards of the LibreTexts platform.