Skip to main content
Medicine LibreTexts

12.2: Etiology

  • Page ID
  • There are many theories regarding the etiology of interstitial cystitis but a deficiency of glycosaminoglycans (GAGS) in the urothelium is best documented. GAGs are the polysaccharide macromolecules which cover the urothelium of bladder, preventing noxious substances in urine (such as potassium) penetrating urothelium and the bladder wall. GAG deficiency leads to urine penetrating the bladder wall, release of neuropeptides resulting in pain.