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4.2: Beta-1 Agonists

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    Dobutamine is a Beta-1 agonist.

    Mechanism of Action: Dobutamine stimulates Beta-1 receptors to increase heart rate, force of contraction, and conduction velocity.

    Indications: Dobutamine is used to treat cardiogenic shock and severe heart failure to increase contractility and cardiac output.

    Nursing Considerations: In IV administration, dilute concentration before administering. Continuously monitor electrocardiogram (ECG), blood pressure, cardiac output, and urine output during therapy. This drug can cause a marked increase in heart rate and blood pressure. Report all adverse reactions promptly, especially labored breathing, angina, palpitations, and dizziness.

    Patient Teaching & Education: The patient should be instructed to inform the nurse immediately if they notice chest pain, shortness of breath, or numbness or tingling in the extremities.[1]

    Now let’s take a closer look at the dobutamine medication grid in Table 4.11.[2]

    Table 4:11 Dobutamine Medication Grid

    Class/Subclass

    Prototype/Generic

    Administration Considerations

    Therapeutic Effects

    Side/Adverse Effects
    Beta-1 agonist dobutamine Continuously monitor ECG, blood pressure, cardiac output, and urine output during therapy Increases heart rate, force of heart contraction, and speed of conduction between SA to AV nodes Marked increase in heart rate and blood pressure

    Report all adverse reactions promptly, especially labored breathing, angina, palpitations, and dizziness
    1. uCentral from Unbound Medicine. https://www.unboundmedicine.com/ucentral↵
    2. This work is a derivative of Daily Med by U.S. National Library of Medicine in the public domain. ↵

    This page titled 4.2: Beta-1 Agonists is shared under a CC BY 4.0 license and was authored, remixed, and/or curated by Ernstmeyer & Christman (Eds.) (OpenRN) via source content that was edited to the style and standards of the LibreTexts platform.