5.4: Leukotriene Receptor Antagonists
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- Ernstmeyer & Christman (Eds.)
- Chippewa Valley Technical College via OpenRN
Montelukast is a leukotriene antagonist medication with a distinctly shaped tablet. See Figure 5.18. [1]
Mechanism of Action
Montelukast blocks leukotriene receptors and decreases inflammation.
Indications for Use
Montelukast is used for the long-term control of asthma and for decreasing the frequency of asthma attacks. It is also indicated for exercise-induced bronchospasm and allergic rhinitis.
Nursing Considerations Across the Lifespan
The medication is safe for children 12 months and older. It is available in granule packets and chewable tablets, as well as regular tablets.
Adverse/Side Effects
Montelukast can cause headache, cough, nasal congestion, nausea, and hepatotoxicity. [2]
Patient Teaching & Education
Patients should be instructed to take medications at the same time each day and at least two hours prior to exercise. They should not discontinue medications without notifying the healthcare provider. [3]
Now let’s take a closer look at the medication grid on montelukast in Table 5.13. [4] , [5] , [6] , [7]
|
Class/Subclass |
Prototype/Generic |
Administration Considerations |
Therapeutic Effects |
Adverse/Side Effects |
|---|---|---|---|---|
| Leukotriene inhibitor | montelukast |
Use as directed; not to be used as “rescue” medication
Typically 3-7 days to reach effectiveness |
Prevention and treatment of asthma and exercise-induced bronchoconstriction |
Headache
Cough Nasal congestion Nausea Hepatotoxicity |
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- Frandsen, G. & Pennington, S. (2018). Abrams’ clinical drug: Rationales for nursing practice (11th ed.). Wolters Kluwer. ↵
- uCentral from Unbound Medicine. https://www.unboundmedicine.com/ucentral ↵
- This work is a derivative of Pharmacology Notes: Nursing Implications for Clinical Practice by Gloria Velarde licensed under CC BY-NC-SA 4.0 . ↵
- Frandsen, G. & Pennington, S. (2018). Abrams’ clinical drug: Rationales for nursing practice (11th ed.). Wolters Kluwer. ↵
- This work is a derivative of Daily Med by U.S. National Library of Medicine in the public domain . ↵
- Adams, M., Holland, N., & Urban, C. (2020). Pharmacology for nurses: A pathophysiologic approach (6th ed.) . pp. 622-63 & 626. Pearson. ↵