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Normal Blood Cells

  • Page ID
    70220

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    Normal Cells.png

    Polymorphonuclear Segmented Neutrophil (PMN)

    • Cell size:  10-16 microns
    • N/C ratio 1:1
    • 2-5 distinct nuclear lobes (filament connecting lobes)
    • Central or eccentric nucleus
    • Deep blue-purple coarsely granular nuclear chromatin (distinct parachromatin)
    • No nucleoli
    • Abundant pink cytoplasm
    • Fine violet-pink specific granules

    PMN \(\PageIndex{}\)

     

    Band Neutrophil

    • Cell size:  10-16 microns
    • N/C ratio 1:1
    • Elongated narrow band shape of uniform thickness, singular lobe
    • Central or eccentric nucleus
    • Deep blue-purple coarsely granular nuclear chromatin (distinct parachromatin)
    • No nucleoli
    • Abundant pink cytoplasm
    • Fine violet-pink specific granules

    Band \(\PageIndex{}\)

     

    Eosinophil

    • Cell size:  10-16 microns
    • N/C ratio 1:1
    • 2 distinct nuclear lobes - rarely 3 or 4 (filament connecting)
    • Central or eccentric nucleus
    • Deep blue-purple coarsely granular nuclear chromatin
    • No nucleoli
    • Abundant pink cytoplasm
    • Large red, uniform specific granules

    Eosinophil \(\PageIndex{}\)

     

    Basophil

    • Cell size:  10-16 microns
    • N/C ratio 1:1
    • 2 distinct nuclear lobes - rarely 3 or 4 (filament connecting)
    • Central or eccentric nucleus
    • Deep blue-purple coarsely granular nuclear chromatin
    • No nucleoli
    • Abundant pale blue cytoplasm
    • Coarse purple-black non-uniform specific granules (water soluble - may dissolve in staining)

    Basophil \(\PageIndex{}\)

    Basophils and immature granulocytes- compare to promyelocytes

     

    Monocyte

    • Cell size:  12-20 microns
    • N/C ratio 2:1 or 1:1
    • Cerebriform or horseshoe shaped nucleus
    • Central nucleus
    • Blue-purple, fine reticular nuclear chromatin (less distinct parachromatin)
    • 0-2 Nucleoli
    • Abundant pale gray-blue cytoplasm. May see pseudopodia and vacuoles
    • Numerous very fine (dust like) red granules evenly dispersed

    Monocyte \(\PageIndex{}\)

     

     

    Lymphocyte

    • Cell size:  7-18 microns (usually 9-12)
    • N/C ratio 4:1 (occasionally 3:1)
    • Round or indented nucleus
    • Eccentric nucleus often with scanty cytoplasm
    • Homogeneous, coarse blue-purple nuclear chromatin (smudged)
    • Nucleoli often absent but may see in mature forms
    • Light to dark blue cytoplasm, scanty to moderate
    • Occasionally a few azurophilic granules seen

    Small Lymph \(\PageIndex{}\)

    Average  to Large Lymph \(\PageIndex{}\)

     

    Reactive Lymphocyte

    • Activated T-Lymph
    • Wandering or Ballerina skirt cytoplasm often indented by adjacent red blood cells
    • Bluer cytoplasm periphery especially where indented by red blood cells
    • Nucleus also has wandering appearance
    • Coarser nuclear chromatin

    Reactive Lymph \(\PageIndex{}\)

     

    Plasmacytoid Lymphocyte

    • Activated B- Lymph
    • Generally considered a lymph transitioning to a plasma cell
    • Slightly larger with darker royal blue cytoplasm and more heavily clumped chromatin
    • May lack very eccentric nucleus and well developed golgi of plasma cell

    Plasmacytoid Lymph \(\PageIndex{}\)

     

    Red Blood Cell

    • Cell size: 6-8 microns
    • Clear pink to red cytoplasm, central pallor 1/3 of cell diameter
    • No cytoplasmic granules

    RBC\(\PageIndex{}\)

     

    Platelet

    • Cell size:  2-4 microns
    • Light blue, fragment of megakaryocyte cytoplasm
    • Evenly dispersed, fine red-purple granules

    Platelet \(\PageIndex{}\)

     

     

     

     


    This page titled Normal Blood Cells is shared under a CC BY-NC-SA 4.0 license and was authored, remixed, and/or curated by Dawn Taylor, Kristin Whitman, and Caroline Doty.

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