Normal Blood Cells
- Page ID
- 70220
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\(\newcommand{\avec}{\mathbf a}\) \(\newcommand{\bvec}{\mathbf b}\) \(\newcommand{\cvec}{\mathbf c}\) \(\newcommand{\dvec}{\mathbf d}\) \(\newcommand{\dtil}{\widetilde{\mathbf d}}\) \(\newcommand{\evec}{\mathbf e}\) \(\newcommand{\fvec}{\mathbf f}\) \(\newcommand{\nvec}{\mathbf n}\) \(\newcommand{\pvec}{\mathbf p}\) \(\newcommand{\qvec}{\mathbf q}\) \(\newcommand{\svec}{\mathbf s}\) \(\newcommand{\tvec}{\mathbf t}\) \(\newcommand{\uvec}{\mathbf u}\) \(\newcommand{\vvec}{\mathbf v}\) \(\newcommand{\wvec}{\mathbf w}\) \(\newcommand{\xvec}{\mathbf x}\) \(\newcommand{\yvec}{\mathbf y}\) \(\newcommand{\zvec}{\mathbf z}\) \(\newcommand{\rvec}{\mathbf r}\) \(\newcommand{\mvec}{\mathbf m}\) \(\newcommand{\zerovec}{\mathbf 0}\) \(\newcommand{\onevec}{\mathbf 1}\) \(\newcommand{\real}{\mathbb R}\) \(\newcommand{\twovec}[2]{\left[\begin{array}{r}#1 \\ #2 \end{array}\right]}\) \(\newcommand{\ctwovec}[2]{\left[\begin{array}{c}#1 \\ #2 \end{array}\right]}\) \(\newcommand{\threevec}[3]{\left[\begin{array}{r}#1 \\ #2 \\ #3 \end{array}\right]}\) \(\newcommand{\cthreevec}[3]{\left[\begin{array}{c}#1 \\ #2 \\ #3 \end{array}\right]}\) \(\newcommand{\fourvec}[4]{\left[\begin{array}{r}#1 \\ #2 \\ #3 \\ #4 \end{array}\right]}\) \(\newcommand{\cfourvec}[4]{\left[\begin{array}{c}#1 \\ #2 \\ #3 \\ #4 \end{array}\right]}\) \(\newcommand{\fivevec}[5]{\left[\begin{array}{r}#1 \\ #2 \\ #3 \\ #4 \\ #5 \\ \end{array}\right]}\) \(\newcommand{\cfivevec}[5]{\left[\begin{array}{c}#1 \\ #2 \\ #3 \\ #4 \\ #5 \\ \end{array}\right]}\) \(\newcommand{\mattwo}[4]{\left[\begin{array}{rr}#1 \amp #2 \\ #3 \amp #4 \\ \end{array}\right]}\) \(\newcommand{\laspan}[1]{\text{Span}\{#1\}}\) \(\newcommand{\bcal}{\cal B}\) \(\newcommand{\ccal}{\cal C}\) \(\newcommand{\scal}{\cal S}\) \(\newcommand{\wcal}{\cal W}\) \(\newcommand{\ecal}{\cal E}\) \(\newcommand{\coords}[2]{\left\{#1\right\}_{#2}}\) \(\newcommand{\gray}[1]{\color{gray}{#1}}\) \(\newcommand{\lgray}[1]{\color{lightgray}{#1}}\) \(\newcommand{\rank}{\operatorname{rank}}\) \(\newcommand{\row}{\text{Row}}\) \(\newcommand{\col}{\text{Col}}\) \(\renewcommand{\row}{\text{Row}}\) \(\newcommand{\nul}{\text{Nul}}\) \(\newcommand{\var}{\text{Var}}\) \(\newcommand{\corr}{\text{corr}}\) \(\newcommand{\len}[1]{\left|#1\right|}\) \(\newcommand{\bbar}{\overline{\bvec}}\) \(\newcommand{\bhat}{\widehat{\bvec}}\) \(\newcommand{\bperp}{\bvec^\perp}\) \(\newcommand{\xhat}{\widehat{\xvec}}\) \(\newcommand{\vhat}{\widehat{\vvec}}\) \(\newcommand{\uhat}{\widehat{\uvec}}\) \(\newcommand{\what}{\widehat{\wvec}}\) \(\newcommand{\Sighat}{\widehat{\Sigma}}\) \(\newcommand{\lt}{<}\) \(\newcommand{\gt}{>}\) \(\newcommand{\amp}{&}\) \(\definecolor{fillinmathshade}{gray}{0.9}\)Polymorphonuclear Segmented Neutrophil (PMN)
- Cell size: 10-16 microns
- N/C ratio 1:1
- 2-5 distinct nuclear lobes (filament connecting lobes)
- Central or eccentric nucleus
- Deep blue-purple coarsely granular nuclear chromatin (distinct parachromatin)
- No nucleoli
- Abundant pink cytoplasm
- Fine violet-pink specific granules
PMN \(\PageIndex{}\)
Band Neutrophil
- Cell size: 10-16 microns
- N/C ratio 1:1
- Elongated narrow band shape of uniform thickness, singular lobe
- Central or eccentric nucleus
- Deep blue-purple coarsely granular nuclear chromatin (distinct parachromatin)
- No nucleoli
- Abundant pink cytoplasm
- Fine violet-pink specific granules
Band \(\PageIndex{}\)
Eosinophil
- Cell size: 10-16 microns
- N/C ratio 1:1
- 2 distinct nuclear lobes - rarely 3 or 4 (filament connecting)
- Central or eccentric nucleus
- Deep blue-purple coarsely granular nuclear chromatin
- No nucleoli
- Abundant pink cytoplasm
- Large red, uniform specific granules
Eosinophil \(\PageIndex{}\)
Basophil
- Cell size: 10-16 microns
- N/C ratio 1:1
- 2 distinct nuclear lobes - rarely 3 or 4 (filament connecting)
- Central or eccentric nucleus
- Deep blue-purple coarsely granular nuclear chromatin
- No nucleoli
- Abundant pale blue cytoplasm
- Coarse purple-black non-uniform specific granules (water soluble - may dissolve in staining)
Basophil \(\PageIndex{}\)
Monocyte
- Cell size: 12-20 microns
- N/C ratio 2:1 or 1:1
- Cerebriform or horseshoe shaped nucleus
- Central nucleus
- Blue-purple, fine reticular nuclear chromatin (less distinct parachromatin)
- 0-2 Nucleoli
- Abundant pale gray-blue cytoplasm. May see pseudopodia and vacuoles
- Numerous very fine (dust like) red granules evenly dispersed
Monocyte \(\PageIndex{}\)
Lymphocyte
- Cell size: 7-18 microns (usually 9-12)
- N/C ratio 4:1 (occasionally 3:1)
- Round or indented nucleus
- Eccentric nucleus often with scanty cytoplasm
- Homogeneous, coarse blue-purple nuclear chromatin (smudged)
- Nucleoli often absent but may see in mature forms
- Light to dark blue cytoplasm, scanty to moderate
- Occasionally a few azurophilic granules seen
Small Lymph \(\PageIndex{}\)
Average to Large Lymph \(\PageIndex{}\)
Reactive Lymphocyte
- Activated T-Lymph
- Wandering or Ballerina skirt cytoplasm often indented by adjacent red blood cells
- Bluer cytoplasm periphery especially where indented by red blood cells
- Nucleus also has wandering appearance
- Coarser nuclear chromatin
Reactive Lymph \(\PageIndex{}\)
Plasmacytoid Lymphocyte
- Activated B- Lymph
- Generally considered a lymph transitioning to a plasma cell
- Slightly larger with darker royal blue cytoplasm and more heavily clumped chromatin
- May lack very eccentric nucleus and well developed golgi of plasma cell
Plasmacytoid Lymph \(\PageIndex{}\)
Red Blood Cell
- Cell size: 6-8 microns
- Clear pink to red cytoplasm, central pallor 1/3 of cell diameter
- No cytoplasmic granules
RBC\(\PageIndex{}\)
Platelet
- Cell size: 2-4 microns
- Light blue, fragment of megakaryocyte cytoplasm
- Evenly dispersed, fine red-purple granules
Platelet \(\PageIndex{}\)