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10.6: Megakaryocytes

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    Notes: Develop and are mainly found in the bone marrow. Maturation usually involves the division of nucleus but not the division of the cytoplasm, this gives rise to a polyploid cell.1

    Nucleus-to-Cytoplasm Ratio: Variable 2

    Nucleoli: N/A 2

    Nucleus:

    Variable number of lobes (2-32)2

    Cytoplasm:2

    Abundant

    Blue to purple cytoplasm

    Reddish blue granules may be visible

    % in Bone Marrow: 5-10 (per field at 100x magnification)2

    % in Peripheral Blood: None


    References:

    1. Lynne Williams J. The Platelet. In: Clinical laboratory hematology. 3rd ed. New Jersey: Pearson; 2015. p. 144–53.

    2. Rodak BF, Carr JH. Megakaryocyte maturation. In: Clinical hematology atlas. 5th ed. St. Louis, Missouri: Elsevier Inc.; 2017. p. 31-40.


    This page titled 10.6: Megakaryocytes is shared under a CC BY-NC 4.0 license and was authored, remixed, and/or curated by Valentin Villatoro and Michelle To (Open Education Alberta) via source content that was edited to the style and standards of the LibreTexts platform; a detailed edit history is available upon request.

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