1.31: Iron, Bilirubin, Porphyrin
- Page ID
- 38611
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\(\newcommand{\avec}{\mathbf a}\) \(\newcommand{\bvec}{\mathbf b}\) \(\newcommand{\cvec}{\mathbf c}\) \(\newcommand{\dvec}{\mathbf d}\) \(\newcommand{\dtil}{\widetilde{\mathbf d}}\) \(\newcommand{\evec}{\mathbf e}\) \(\newcommand{\fvec}{\mathbf f}\) \(\newcommand{\nvec}{\mathbf n}\) \(\newcommand{\pvec}{\mathbf p}\) \(\newcommand{\qvec}{\mathbf q}\) \(\newcommand{\svec}{\mathbf s}\) \(\newcommand{\tvec}{\mathbf t}\) \(\newcommand{\uvec}{\mathbf u}\) \(\newcommand{\vvec}{\mathbf v}\) \(\newcommand{\wvec}{\mathbf w}\) \(\newcommand{\xvec}{\mathbf x}\) \(\newcommand{\yvec}{\mathbf y}\) \(\newcommand{\zvec}{\mathbf z}\) \(\newcommand{\rvec}{\mathbf r}\) \(\newcommand{\mvec}{\mathbf m}\) \(\newcommand{\zerovec}{\mathbf 0}\) \(\newcommand{\onevec}{\mathbf 1}\) \(\newcommand{\real}{\mathbb R}\) \(\newcommand{\twovec}[2]{\left[\begin{array}{r}#1 \\ #2 \end{array}\right]}\) \(\newcommand{\ctwovec}[2]{\left[\begin{array}{c}#1 \\ #2 \end{array}\right]}\) \(\newcommand{\threevec}[3]{\left[\begin{array}{r}#1 \\ #2 \\ #3 \end{array}\right]}\) \(\newcommand{\cthreevec}[3]{\left[\begin{array}{c}#1 \\ #2 \\ #3 \end{array}\right]}\) \(\newcommand{\fourvec}[4]{\left[\begin{array}{r}#1 \\ #2 \\ #3 \\ #4 \end{array}\right]}\) \(\newcommand{\cfourvec}[4]{\left[\begin{array}{c}#1 \\ #2 \\ #3 \\ #4 \end{array}\right]}\) \(\newcommand{\fivevec}[5]{\left[\begin{array}{r}#1 \\ #2 \\ #3 \\ #4 \\ #5 \\ \end{array}\right]}\) \(\newcommand{\cfivevec}[5]{\left[\begin{array}{c}#1 \\ #2 \\ #3 \\ #4 \\ #5 \\ \end{array}\right]}\) \(\newcommand{\mattwo}[4]{\left[\begin{array}{rr}#1 \amp #2 \\ #3 \amp #4 \\ \end{array}\right]}\) \(\newcommand{\laspan}[1]{\text{Span}\{#1\}}\) \(\newcommand{\bcal}{\cal B}\) \(\newcommand{\ccal}{\cal C}\) \(\newcommand{\scal}{\cal S}\) \(\newcommand{\wcal}{\cal W}\) \(\newcommand{\ecal}{\cal E}\) \(\newcommand{\coords}[2]{\left\{#1\right\}_{#2}}\) \(\newcommand{\gray}[1]{\color{gray}{#1}}\) \(\newcommand{\lgray}[1]{\color{lightgray}{#1}}\) \(\newcommand{\rank}{\operatorname{rank}}\) \(\newcommand{\row}{\text{Row}}\) \(\newcommand{\col}{\text{Col}}\) \(\renewcommand{\row}{\text{Row}}\) \(\newcommand{\nul}{\text{Nul}}\) \(\newcommand{\var}{\text{Var}}\) \(\newcommand{\corr}{\text{corr}}\) \(\newcommand{\len}[1]{\left|#1\right|}\) \(\newcommand{\bbar}{\overline{\bvec}}\) \(\newcommand{\bhat}{\widehat{\bvec}}\) \(\newcommand{\bperp}{\bvec^\perp}\) \(\newcommand{\xhat}{\widehat{\xvec}}\) \(\newcommand{\vhat}{\widehat{\vvec}}\) \(\newcommand{\uhat}{\widehat{\uvec}}\) \(\newcommand{\what}{\widehat{\wvec}}\) \(\newcommand{\Sighat}{\widehat{\Sigma}}\) \(\newcommand{\lt}{<}\) \(\newcommand{\gt}{>}\) \(\newcommand{\amp}{&}\) \(\definecolor{fillinmathshade}{gray}{0.9}\)FOR QUESTIONS 1 - 3 use the following KEY:
- formation of amino levulinic acid (ALA) by ALA synthase
- conversion of ALA to porphobilinogen (PB) by ALA dehydratase
- conversion of PB to Uroporphyrin I
- conversion of PB to Uroporphyrin III
- conversion of coproporphyrin to protoporphyrinogen IX
- Normally the feed—back inhibition by Heme operates at which one of the above steps?:
- In acute intermittent porphyria this rate-limiting step is defective:
- This step is severely inhibited by lead:
Use the following Key to answer Questions 4-9:
- 1, 2, and 3 are correct
- 1 and 3 are correct
- 2 and 4 are correct
- only 4 is correct
- all are correct
- Most of the iron in the body is found in:
- hemoglobin
- haptoglobin
- ferritin
- peroxides
- The transport protein(s) of iron is/are:
- ferritin
- haptoglobin
- hemosiderin
- transferrin
- The total iron binding capacity (TIBC) calculated from:
- transferrin
- ferritin
- serum iron
- hemosiderin
- Heme is degraded to form the following compounds:
- a linear tetraphrrole
- biliverdin
- bilirubin
- protoporphyrin
- Bilirubin is bound by which of the following compound(s)?
- bile acids
- haptoglobin
- hemoglobin
- albumin
- Heme synthesis is an integral part of which of the following body systems?
- respiratory
- bone marrow
- genitourinary
- hepatic
- Delta bilirubin is:
- free, unconjugated bilirubin
- unconjugated bilirubin, covalently bound to albumin
- bilirubin monoglucuronide
- conjugated bilirubin that does not react in direct reaction
- none of the above
- Measurement of urinary urobilinogen is:
- useful in detection of renal disease
- useful in detection of inborn errors of heme synthesis
- useful in detection of liver disease
- useful for screening for porphobilinogens
- not particularly useful for any of the above
- Answer
-
- a (p. 664)
- d (p. 665-667)
- b (p. 669)
- b (p. 659)
- d (p. 660)
- b (p. 661-662)
- a (p. 671)
- d (p. 671)
- c (p. 664)
- b (p. 671)
- e (p. 673)