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8.2: Pericardial Disease - Chronic

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    The pericardial layers may become rigid, thickened, and may fuse, resulting in restriction of cardiac filling; constrictive pericarditis. In contrast to cardiac tamponade, where cardiac is hampered throughout diastole, cardiac filling is prohibited in the last two-thirds of diastole in constrictive pericarditis, with preserved abrupt filling in early diastole.

    Chronic constrictive pericarditis

    Any form of pericarditis may end in constrictive pericarditis, presenting with chronic fatigue, dyspnoea, jugular distension, proto-diastolic pericardial knock, hepatomegaly, ascites, peripheral oedema, and pleural effusion. Atrial fibrillation is a common finding, and diffuse flattened or negative T-waves are usually present. These suggestive clinical findings, in addition to a physiology of restriction or constriction on echocardiography, and the presence of a thickened pericardium provide the diagnosis. However, a thickened pericardium may be absent, which does not rule out constrictive pericarditis. Pericardiectomy is the only effective treatment, which should be instituted shortly after diagnosis, as surgical mortality increases with increasing age and functional impairment.

    Constrictive Pericarditis Restrictive Cardiomyopathy
    Physical Examination
    Early diastolic precordial impulse Apical impulse may be prominent
    Pericardial Knock
    No murmur Third sound may be present

    Regurgitant murmur common

    Electrocardiography
    Low voltage

    Frequent atrial fibrillation

    Normal QRS complex

    Low voltage in amiloidosis

    Frequent atrial fibrillation

    Bundle branch block

    Chest Radiography
    Pericardial calcification possible Non-specific cardiomegaly
    Echocardiography
    Normal wall thickness Pericardial thickening
    Diastolic notch of interventricular septum
    Increased wall thickness (amyloidosis) Enlarged left and right atria
    Doppler studies e' septal =8 cm/sec and normal S' mitral annular velocity
    Mitral inflow increase during expiration

    Mitral flow propagation velocity M-mode colour =45cm/s

    Increased diastolic flow reversal in the hepatic vein with expiration e' septal <8cm/s and decreased mitral annular velocity

    Mitral inflow velocity without respiratory variation

    Mitral flow propagation velocity M-mode colour <45cm/s

    Increased diastolic flow reversal in the hepatic vein with inspiration

    Cardiac catheterization
    RVEDP and LVEDP usually equal

    RV systolic pressure <50mmHg

    RVEDP >one-third of RV systolic pressure

    LVEDP often >5mm greater than RVEDP

    Endomyocardial biopsy
    Normal or non-specific changes May reveal specific causes
    CT/MR imaging
    Pericardium thickened or calcified Normal pericardium
    CT, computer tomography; e', e wave velocity by tissue velocity imaging;
    LVEDP, left ventricular end-diastolic pressure;

    MR, magnetic resonance;

    RV, right ventricular;

    RVEDP, right ventricular end-diastolic pressure.

    Table 8.3.1: Differential diagnosis between chronic constrictive pericarditis and restrictive cardiomyopathy.

    Subacute elastic constriction

    Elastic cardiac constriction, in contrast to the rigid chronic constriction, results from an elastic thickened pericardium, which still allows distension during the respiratory cycle. It may be seen in the first period after acute inflammatory or infectious pericarditis, and may progress to chronic pericardial constriction, or prove to be a transient process.

    Effusive-constrictive pericarditis

    Presenting with cardiac tamponade on admission, effusive-constrictive pericarditis is characterized by a persistent increase in right atrial and end-diastolic ventricular pressures after intrapericardial pressure has been alleviated by pericardiocentesis. Apart from idiopathic cases, it may accompany chest radiation, cardiac surgery, neoplasia, and tuberculosis. Most frequently, the disease will progress to persistent constriction for which epicardiectomy is indicated, but it may rarely be a transient phenomenon.

    Transient cardiac constriction

    Clinical and hemodynamic features of constrictive pericarditis may dissipate spontaneously, which is seen commonly (20%) in idiopathic acute pericarditis with effusion, but may also be seen in tuberculous and purulent pericarditis. Hence, a primarily conservative approach may alleviate the need for epicardiectomy.


    This page titled 8.2: Pericardial Disease - Chronic is shared under a CC BY-NC-SA 3.0 license and was authored, remixed, and/or curated by de Jong and van der Waals Eds. (Cardionetworks Foundation and the Health[e]Foundation) via source content that was edited to the style and standards of the LibreTexts platform.