Skip to main content
Medicine LibreTexts

11: One-Carbon Metabolism Micronutrients

  • Page ID
    1373
  • [ "article:topic-guide", "One-Carbon Metabolism", "authorname:blindshield" ]

    Three B vitamins are involved in what is known as 1-carbon metabolism. This is the movement of 1 carbon units, generally methyl groups (CH3). It is similar to the movement of the amino group that occurs in transamination. Folate, vitamin B12, and vitamin B6 are the B vitamins involved in 1-carbon metabolism.

    • 11.1: Folate & Folic Acid
      Vitamin B₁₂ is unique among vitamins in that it contains an element (cobalt) and is found almost exclusively in animal products. Neither plants nor animals can synthesize vitamin B₁₂. Instead, vitamin B₁₂ in animal products is produced by microorganisms within the animal that the products came from. Animals consume the microorganisms in soil or bacteria in ruminant animals that produce vitamin B₁₂.
    • 11.2: Vitamin B₁₂
      Vitamin B₁₂ is unique among vitamins in that it contains an element (cobalt) and is found almost exclusively in animal products. Neither plants nor animals can synthesize vitamin B₁₂, vitamin B₁₂ in animal products is produced by microorganisms within the animal that the products came from. Animals consume the microorganisms in soil or bacteria in ruminant animals that produce vitamin B₁₂.
    • 11.3: B Vitamins, Homocysteine & Cardiovascular Disease
      Homocysteine is a sulfur-containing, non-proteinogenic (not used for making proteins) amino acid whose structure is shown in the figure below. Elevated circulating homocysteine levels have been found in people with cardiovascular disease. Folate, vitamin B6, and vitamin B₁₂ contribute to the conversion of homocysteine to methionine by providing methyl groups, thereby decreasing homocysteine levels.

    Thumbnail: The chemical structure of pyridoxal phosphate, a form of vitamin B6. Image used with permission (Public Domain; Fvasconcellos).

    Contributors