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4.3: Accessory Structures of the Skin

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    63384

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    By the end of the section, you will be able to:
    • Identify the accessory structures of the skin
    • Describe the structure and function of hair and nails
    • Describe the structure and function of sweat glands and sebaceous glands

    Accessory structures of the skin include hair, nails, sweat glands, and sebaceous glands. These structures embryologically originate from the epidermis and can extend down through the dermis into the hypodermis.

    Hair

    Aside from the body regions with thick skin, e.g. the palms of our hands or the soles of our feet, the entire surface of our body has hair. The two main types of hair are the shorter and thinner "vellus" hairs (peach fuzz) and the longer and thicker "terminal" hairs. Examples of terminal hairs include the hair on your head, facial hair, eyelashes, eyebrows, pubic hair, chest/abdominal hair, nose hair and ear hair.

    Hair is a keratinous filament growing out of the epidermis. It is primarily made of dead, keratinized cells. Strands of hair originate in an epidermal penetration of the dermis called the hair follicle. The hair shaft is the part of the hair not anchored to the follicle, and much of this is exposed at the skin’s surface. The rest of the hair, which is anchored in the follicle, lies below the surface of the skin and is referred to as the hair root. The hair root ends deep in the dermis at the hair bulb, and includes a layer of mitotically active basal cells called the hair matrix (Figure \(\PageIndex{1}\)) and (Figure \(\PageIndex{2}\)).

    Hair follicle structure.png
    Figure \(\PageIndex{1}\): Hair Follicles and Hair. Hair follicles originate in the dermis and extend to to apical surface of the epidermis. The hair root and bulb are enclosed within an epithelial and connective tissue follicle, while the shaft extends beyond the surface. (Image credit: "Hair Follicles and Hair" by Jennifer Lange is licensed under CC BY-NC-SA 4.0, modification of original by Scientific Animations.)

    Just as the basal layer of the epidermis forms the layers of epidermis that get pushed to the surface as the dead skin on the surface sheds, the basal cells of the hair bulb divide and push cells outward in the hair root and shaft as the hair grows.  Hair growth begins with the production of keratinocytes by the basal cells of the hair bulb. As new cells are deposited at the hair bulb, the hair shaft is pushed through the follicle toward the surface. Keratinization is completed as the cells are pushed to the skin surface to form the shaft of hair that is externally visible. The external hair is completely dead and composed entirely of keratin. For this reason, our hair does not have sensation. Furthermore, you can cut your hair or shave without damaging the hair structure because the cut is superficial. Most chemical hair removers also act superficially; however, electrolysis and yanking both attempt to destroy the hair bulb so hair cannot grow.

    SkinThin_HairandAssociatedStructuresSlide@40x.png
    Figure \(\PageIndex{2}\): Hair Follicle Histology. The slide shows a cross-section of a hair follicle and its associated structures. Often the hair itself is not seen on the slide, but it would occupy the center of the follicle. (Image credit: "Hair Follicle Histology" by Jennifer Lange, slide provided by the Regents of the University of Michigan Medical School under CC BY-NC-SA 4.0 © 2022)

    Hair serves a variety of functions, including protection, sensory input, thermoregulation, and communication. For example, hair on the head protects the skull from the sun. The hair in the nose and ears, and around the eyes (eyelashes) defends the body by trapping and excluding dust particles that may contain allergens and microbes. Hair of the eyebrows prevents sweat and other particles from dripping into and bothering the eyes. Hair also has a sensory function due to sensory innervation by a hair root plexus surrounding the base of each hair follicle. Hair is extremely sensitive to air movement or other disturbances in the environment, much more so than the skin surface. This feature is also useful for the detection of the presence of insects or other potentially damaging substances on the skin surface. Each hair root is connected to a smooth muscle called the arrector pili that contracts in response to nerve signals from the sympathetic nervous system, making the external hair shaft “stand up.” The primary purpose for this is to trap a layer of air to add insulation. This is visible in humans as goose bumps and even more obvious in animals with a heavier coat than most humans, such as dogs and cats that raise their fur when alarmed.

    Hair Growth

    On average, 50 hairs are lost and replaced per day. Hair loss occurs if there is more hair shed than what is replaced and can happen due to hormonal or dietary changes. Hair loss can also result from the aging process, or the influence of hormones.

    Hair Color and Texture

    Similar to the skin, hair gets its color from the pigment melanin, produced by melanocytes in the hair papilla. Different hair color results from differences in the type and amounts of melanin produced, which is determined by our genetics. Two forms of melanin are found in human hair: eumelanin and pheomelanin.  Eumelanin is a black/brown form of the pigment and is the dominant pigment in brown hair and black hair while pheomelanin is a red pigments that is the dominant pigment in red hair. Blond hair results when you have only a small amount of melanin in the hair.  As a person ages, the melanin production decreases, and hair tends to lose its color and becomes gray and/or white.

    The shape of the hair follicle determines the shape of the hair shaft:  round hair follicles produce straight hair while ovoid follicles produce varying degrees of waviness or curl.  Wavy hair tends to have a "D" shape to the shaft while curly hair is more oval, and the flatter the oval the curlier the hair.  As a rough measure of curl, when you examine a slide from the scalp look at the angle of the hair follicle relative to the epidermal surface - the sharper the angle the more likely the hair is curly.

    Glands

    Glands perform the secretory functions of the integumentary system: producing and releasing sweat, pheromones, and oils. (Figure \(\PageIndex{4}\))

    Thin Skin Accessory Organs.pngFigure \(\PageIndex{4}\): Accessory Organs of the Integument. Merocrine sweat glands and sebaceous glands are found in all regions of the body that have hair.  (Image credit: "Integumentary System - Accessory Organs" by Sofia Elizondo and Jennifer Lange is licensed under CC BY-NC-SA 4.0, modification of original by Scientific Animations.)

    Sweat Glands

    Sweat glands develop from epidermal projections into the dermis. There are two types of sweat glands, each secreting slightly different products.

    An eccrine (merocrine) sweat gland is type of gland that produces a sweat for thermoregulation. These glands are found all over the skin’s surface, but are especially abundant on the palms of the hand, the soles of the feet, and the forehead (Figure \(\PageIndex{5}\)). They are coiled glands lying deep in the dermis, with the duct rising up to a pore on the skin surface, where the sweat is released. This type of sweat, released by exocytosis, is hypotonic and composed mostly of water, with some salt, antibodies, traces of metabolic waste, and an antimicrobial peptide. Eccrine glands are a primary component of thermoregulation in humans and thus help to maintain homeostasis.

    Eccrine sweat gland histology.jpeg
    Apocrine sweat gland histology.jpeg
    Figure \(\PageIndex{5}\): Eccrine and Aprocrine Glands. Histologically eccrine sweat glands have fewer coils of tube with smaller lumens than apocrine sweat glands. Apocine sweat glands are located deeper in the dermis/hypodermis than eccrine sweat glands. (Image credit: At 400x - "Eccrine et Apocrine" by Le-prof-histo, CC BY-SA 4.0, via Wikimedia Commons; at 100x "Eccrine and Apocrine Sweat Glands" by Jennifer Lange; micrographs provided by Virginia Commonwealth University under CC-BY-NC-SA 4.0))

    An apocrine sweat gland is usually associated with hair follicles in densely hairy areas, such as armpits and genital regions. Apocrine sweat glands are larger than eccrine sweat glands and lie deeper in the dermis, sometimes even reaching the hypodermis, with the duct normally emptying into the hair follicle (Figure \(\PageIndex{6}\)). In addition to water and salts, apocrine sweat includes organic compounds that make the sweat thicker and subject to bacterial decomposition and subsequent smell. The release of this sweat is under both nervous and hormonal control, and plays a role in the poorly understood human pheromone response. Most commercial antiperspirants use an aluminum-based compound as their primary active ingredient to stop sweat. When the antiperspirant enters the sweat gland duct, the aluminum-based compounds precipitate due to a change in pH and form a physical block in the duct, which prevents sweat from coming out of the pore.

    Hair follicle with glands.png
    Figure \(\PageIndex{6}\): Glands of the Hair Follicle.  Apocrine sweat glands and sebaceous glands secrete their products directly into the hair follicle. (Image credit: "Hair Follicle and Glands" by Jennifer Lange is licensed under CC BY-NC-SA 4.0, modification of original by Scientific Animations.)

    Sebaceous Glands

    A sebaceous gland is a type of oil gland that is found all over the body and helps to lubricate and waterproof the skin and hair. Most sebaceous glands are associated with hair follicles and the hair acts as a wick to draw the oils to the skin surface (Figure \(\PageIndex{7}\)).

    Sebaceous gland LM @100x.PNG
    Figure \(\PageIndex{7}\): Sebaceous Gland. The oils from a sebaceous gland are secreted directly into the hair follicle. Histologically they appear as clusters of white circles with a stained ring (plasma membrane) on the outside and a dark central dot (nucleus). LM @ 100x. (Image credit: "Sebaceous Gland" by Jennifer Lange; micrographs provided by Virginia Commonwealth University under CC-BY-NC-SA 4.0)

    They generate and excrete sebum, a mixture of lipids, onto the skin surface, thereby naturally lubricating the dry and dead layer of keratinized cells of the stratum corneum, keeping it pliable and preventing drying and cracking. The fatty acids of sebum also have antibacterial properties, and prevent water loss from the skin in low-humidity environments. The secretion of sebum is stimulated by hormones, many of which do not become active until puberty. Thus, sebaceous glands are relatively inactive during childhood.

    Nails

    The nail bed is a specialized structure of the epidermis that is found at the tips of our fingers and toes. The nail body is formed on the nail bed, and protects the tips of our fingers and toes as they are the farthest extremities and the parts of the body that experience the maximum mechanical stress (Figure \(\PageIndex{3}\)). In addition, the nail body forms a back-support for picking up small objects with the fingers. The nail body is composed of densely packed dead keratinocytes. The epidermis in this part of the body has evolved a specialized structure upon which nails can form. The nail body forms at the nail root, which has a matrix of proliferating cells from the stratum basale that enables the nail to grow continuously. The nail bed is rich in blood vessels, making it appear pink, except at the base, where a thick layer of epithelium over the nail matrix forms a crescent-shaped region called the lunula (the “little moon”). 

    Nail structure.jpg
    Figure \(\PageIndex{3}\): Nails. The nail is an accessory structure of the integumentary system. (Image credit: "Nails" by OpenStax is licensed under CC BY 4.0, labeling modifications by Jennifer Lange.)

    Concept Review

    Accessory structures of the skin include hair, nails, sweat glands, and sebaceous glands. Hair is made of dead keratinized cells, and gets its color from melanin pigments. Nails, also made of dead keratinized cells, protect the extremities of our fingers and toes from mechanical damage. Sweat glands and sebaceous glands produce sweat and sebum, respectively. Each of these fluids has a role to play in maintaining homeostasis. Sweat cools the body surface when it gets overheated and helps excrete small amounts of metabolic waste. Sebum acts as a natural moisturizer and keeps the dead, flaky, outer keratin layer healthy.


    Review Questions

    Q. In response to stimuli from the sympathetic nervous system, the arrector pili ________.

    A. are glands on the skin surface

    B. can lead to excessive sweating

    C. are responsible for goose bumps

    D. secrete sebum

    Answer

    Answer: C

    Q. The hair matrix contains ________.

    A. the hair follicle

    B. the hair shaft

    C. the glassy membrane

    D. a layer of basal cells

    Answer

    Answer: D

    Q. Eccrine sweat glands ________.

    A. are present on hair

    B. are present in the skin throughout the body and produce watery sweat

    C. produce sebum

    D. act as a moisturizer

    Answer

    Answer: B

    Q. Sebaceous glands ________.

    A. are a type of sweat gland

    B. are associated with hair follicles

    C. may function in response to touch

    D. release a watery solution of salt and metabolic waste

    Answer

    Answer: B

    Q. Similar to the hair, nails grow continuously throughout our lives. Which of the following is furthest from the nail growth center?

    A. nail bed

    B. hyponychium

    C. nail root

    D. eponychium

    Answer

    Answer: B

    Critical Thinking Questions

    Q. Explain the differences between eccrine and apocrine sweat glands.

    Answer

    A. Eccrine sweat glands are all over the body, especially the forehead and palms of the hand. They release a watery sweat, mixed with some metabolic waste and antibodies. Apocrine glands are associated with hair follicles. They are larger than eccrine sweat glands and lie deeper in the dermis, sometimes even reaching the hypodermis. They release a thicker sweat that is often decomposed by bacteria on the skin, resulting in an unpleasant odor.

    Q. Describe the structure and composition of nails.

    Answer

    A. Nails are composed of densely packed dead keratinocytes. They protect the fingers and toes from mechanical stress. The nail body is formed on the nail bed, which is at the nail root. Nail folds, folds of skin that overlap the nail on its side, secure the nail to the body. The crescent-shaped region at the base of the nail is the lunula.

    Glossary

    apocrine sweat gland
    type of sweat gland that is associated with hair follicles in the armpits and genital regions
    arrector pili
    smooth muscle that is activated in response to external stimuli that pull on hair follicles and make the hair “stand up”
    cortex
    in hair, the second or middle layer of keratinocytes originating from the hair matrix, as seen in a cross-section of the hair bulb
    cuticle
    in hair, the outermost layer of keratinocytes originating from the hair matrix, as seen in a cross-section of the hair bulb
    eccrine sweat gland (also merocrine sweat gland)
    type of sweat gland that is common throughout the skin surface; it produces a hypotonic sweat for thermoregulation
    hair
    keratinous filament growing out of the epidermis
    hair bulb
    structure at the base of the hair root that surrounds the dermal papilla
    hair follicle
    cavity or sac from which hair originates
    hair matrix
    layer of basal cells from which a strand of hair grows
    hair papilla
    mass of connective tissue, blood capillaries, and nerve endings at the base of the hair follicle
    hair root
    part of hair that is below the epidermis anchored to the follicle
    hair shaft
    part of hair that is above the epidermis but is not anchored to the follicle
    lunula
    basal part of the nail body that consists of a crescent-shaped layer of thick epithelium
    merocrine sweat gland (also eccrine sweat gland)
    type of sweat gland that is common throughout the skin surface; it produces a hypotonic sweat for thermoregulation
    nail bed
    layer of epidermis upon which the nail body forms
    nail body
    main keratinous plate that forms the nail
    nail cuticle
    fold of epithelium that extends over the nail bed, also called the eponychium
    nail fold
    fold of epithelium at that extend over the sides of the nail body, holding it in place
    nail root
    part of the nail that is lodged deep in the epidermis from which the nail grows
    sebaceous gland
    type of oil gland found in the dermis all over the body and helps to lubricate and waterproof the skin and hair by secreting sebum
    sebum
    oily substance that is composed of a mixture of lipids that lubricates the skin and hair

    Contributors and Attributions


    This page titled 4.3: Accessory Structures of the Skin is shared under a CC BY-NC-SA 4.0 license and was authored, remixed, and/or curated by Jennifer Lange et al..