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12.5: Treatment

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    Medical Treatment

    • Sodium Pentosan Polysulphate (Tavan SP): This is a synthetic form of GAG that replenishes the deficient GAG layer
    • Amitryptiline: Useful for pain control
    • Hydroxyzine (Aterax): (Antihistamine) Some cases of IC are associated with an allergic response and hence an antihistamine may prove beneficial.

    It is recommended that above three agents are used together to maximise effect.

    • Anticholinergics: Usually ineffective in this condition

    Intravesical Treatment

    • Dimethylsulphoxide (DMSO)
    • Heparin based solutions


    • Bladder hydrodistention: Bladder distention under anaesthesia often gives good temporary symptomatic relief and can be repeated.
    • Surgery: Only in highly selected cases and includes cystoplasty to increase bladder capacity and occasionally cystectomy and urinary diversion.

    This page titled 12.5: Treatment is shared under a CC BY-NC-SA 2.5 license and was authored, remixed, and/or curated by Stephen Jeffery and Peter de Jong via source content that was edited to the style and standards of the LibreTexts platform; a detailed edit history is available upon request.