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10.5: Niacin

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There are two forms of niacin: nicotinic acid and nicotinamide (aka niacinamide), that have a carboxylic acid group or amide group, respectively. The structure of nicotinic acid and nicotinamide are shown below.

clipboard_e6dafd296539af19edbc02440206c95bb.png
Figure 10.5.1: Structure of nicotinic acid1
clipboard_e511ef3d5e66f9a4ad07879fdf0b9d5e0.png
Figure 10.5.2: Structure of nicotinamide2

Query 10.5.1

Niacin is important for the production of two cofactors: nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP+). The structure of NAD is shown below; you can clearly see the nicotinamide at the top right of the molecule.

clipboard_e87957cd9b69c215b0bc1ad1ff89680fe.png
Figure 10.5.3: Structure of NAD3

NAD is reduced to form NADH, as shown below.

clipboard_eae60eb91c1c5f62953e72d171911c872.png
Figure 10.5.4: Reduction of NAD to NADH4

The structure of NADP+ is exactly the same as NAD, except it has an extra phosphate group off the bottom of the structure, as shown below.

clipboard_eb94ac0ab5ac2978cefb0fa1cacce56bc.png
Figure 10.5.5: Structure of NADP+5

Like NAD, NADP+ can be reduced to NADPH.

Query 10.5.2

Niacin is unique in that it can be synthesized from the amino acid tryptophan as shown below. An intermediate in this synthesis is kynurenine. Many reactions occur between this compound and niacin, and riboflavin and vitamin B6 are required for two of these reactions.

clipboard_e4e999a956edf447cc77f98c58177f7a9.png
Figure 10.5.6: Tryptophan can be used to synthesize niacin6

To account for niacin synthesis from tryptophan, niacin equivalents (NE) were created by the DRI committee to account for the amount of niacin in foods as well as their tryptophan content. It takes approximately 60 mg of tryptophan to make 1 mg of niacin. Thus, the conversions to niacin equivalents are:

1mgNiacin=1NE

60mgTryptophan=1NE

The tryptophan levels of most foods is not known, but a good estimate is that tryptophan is 1% of amino acids in protein7. Thus, lets take peanut butter, smooth style, with salt as an example8.

Example 10.5.1: Peanut Butter

The peanut butter contains 13.403 mg of niacin and 25.09 g of protein8.

Step 1: Calculate the amount of tryptophan:

25.09g×0.01(the numerical value of 1%)=0.2509gof tryptophan

Step 2: Convert Grams to Milligrams

0.2509g×1000mg/g=250.9mgof tryptophan

Step 3: Calculate NE from tryptophan (Equation ???)

250.9mgof tryptophan60mgof tryptophan/1NE=4.182NE

Step 4: Add NEs together

13.403NE(from niacin)+4.182(from tryptophan)=17.585NE

Query 10.5.3

Most niacin we consume is in the form of nicotinamide and nicotinic acid9, and in general is well absorbed using an unresolved carrier10. However, in corn, wheat, and certain other cereal products, niacin bioavailability is low. In these foods, some niacin (~70% in corn) is tightly bound, making it unavailable for absorption. Treating the grains with a base frees the niacin and allows it to be absorbed. After absorption nicotinamide is the primary circulating form7,9.

Query 10.5.4

Niacin Functions

Approximately 200 enzymes require NAD or NADP+. We will go through some selected functions of NAD and NADP+. The following figures and legends show and describe the functions of NAD and NADP+.

clipboard_ebc5280c4a04071e3afe65fb08b0639f6.png
Figure 10.5.7: NAD is required for glycolysis11
clipboard_e4df1b47c87a3a2a3b0d7dcc525607e6e.png
Figure 10.5.8: NAD is required for the transition reaction and at three different points in the citric acid cycle12
clipboard_e29c92862666aa18aee18ca62b837a359.png
Figure 10.5.9: NAD is required for fatty acid oxidation
clipboard_ed445ed3c720314c5655ddeb3ae8af824.png
Figure 10.5.10: Alcohol oxidation; NAD is required by alcohol dehydrogenase, and the MEOS uses NADPH13,14
clipboard_efeed4dd9a15c36113c55421ff6635486.png
Figure 10.5.11: Fatty acid synthesis uses NADPH15

HMG CoA reductase, the rate-limiting enzyme in cholesterol synthesis, uses NADPH. NADPH is also used by the antioxidant enzyme glutathione reductase as shown in the link below9.

Query 10.5.5

Niacin Deficiency & Toxicity

Pellagra is a niacin deficiency. This is no longer a common deficiency in developed countries, but was in the U.S. in the early 1900s. This was because corn was a staple crop, meaning it was what people primarily consumed. The bioavailability of niacin from corn is poor unless treated with a base to release the bound niacin. The symptoms of pellagra are the 3 D's:

  • Dementia
  • Dermatitis
  • Diarrhea

Some refer to 4 D's in which the 4th D is death if the condition is not managed. The following pictures show the symptoms of pellagra.

clipboard_eb457c4675f2a8f7e62b5020e59ba2e2b.png
Figure 10.5.12: The 3 D's of pellagra16
clipboard_e8342afd1ad6a05ed8a4aa82516207316.png
Figure 10.5.13: A man with pellagra; notice the dermatitis on his arms17

The link below shows another picture of a person suffering from dermatitis as a result of pellagra.

Web Link

Pellagra

Query 10.5.6

Dietary niacin toxicity is rare. However, nicotinic acid (not) can improve people's lipid profiles when consumed at levels far above the RDA. For instance the RDA and upper limit (UL) is 14 or 16 (women & men) and 35 mg (both), respectively. Many people are taking 1-2 grams (up to 6 g/day) to get the benefits in their plasma lipid profiles as shown in the table below7,9.

Table 10.5.1: Effects of nicotinic acid (>1.5 g/day) on plasma lipid profile18
Measure Change
VLDL ↓ 25-40%
LDL ↓ 6-22%
HDL ↑ 18-35%
Total Cholesterol ↓ 21-44%
Triglycerides ↓ 21-44%

It should be pointed out that there are special supplements for this purpose that include a slower release nicotinic acid that helps prevent the toxicity symptoms (nicotinamide is not toxic). A slow (aka long or extended) release form of niacin for people with atherosclerosis is Niaspan®. The link below is to Niaspan’s site.

Web Link

Niaspan®

A study found that Niaspan plus a statin was no better than a statin alone in preventing heart attacks, despite improvements in HDL and triglyceride concentrations. This result challenged the understanding of the importance of HDL and triglyceride concentrations to heart attack risk. The link below explains this study’s results.

The most well known of the toxicity symptoms is "niacin flush", which is a dilation of capillaries accompanied by tingling that can become painful. This symptom is noted to occur at lower levels than the other toxicity symptoms19. Other symptoms include:

  • Gastrointestinal Distress
  • Liver Damage

A nicotinic acid receptor GPR109A, which is present in adipocytes and immune cells, is believed to mediate niacin flush, but the beneficial effects on lipid profiles do not appear to be mediated by it20,21. It is not clear at this time the mechanism of action for the improvements in lipid profiles20. However, it appears that the nicotinic acid receptor stated above (GPR109A) increases glucose uptake in the intestine. Pharmacological levels of 1-3g of nicotinic acid administration has been found to result in a rapid reduction of high levels of blood lipids22. However, the increased glucose uptake and rapid reduction in lipid levels has been suggested to lead to a prediabetic state when ingesting these high pharmacological levels more than 100 times the RDA. Thus, nicotinic acid administration needs to be carefully prescribed and monitored by a physician.

Based on the benefits of nicotinic acid supplementation on blood lipid level, you might think this is an ideal candidate for treatment of diabetes or cardiovascular disease. Research investigating nicotinic acid supplementation on both of these disease states has found positive and negative impacts on participants. Although, at first glance nicotinic acid supplementation appears very promising, the detrimental effects on the glucose system are too great for nicotinic acid to be a long term cure. Several clinical trials have investigated the impacts of nicotinic acid supplementation in diabetic patients and patients with cardiovascular disease. The primary outcome of improved lipid levels was observed, however, at the cost of glucose response. Multiple studies observed an increase in the risk of developing diabetes following nicotinic acid supplementation. The lipid levels were corrected, albeit at the expense of poor glucose function. This research has shown the importance of nicotinic acid in improving lipid levels and therefore is currently used in combination with other drugs to improve lipid levels in patients23

Query 10.5.7

References

  1. en.Wikipedia.org/wiki/File:Niacinstr.png
  2. en.Wikipedia.org/wiki/File:Ni..._structure.svg
  3. en.Wikipedia.org/wiki/File:NAD%2B_phys.svg
  4. en.Wikipedia.org/wiki/File:NA..._reduction.svg
  5. en.Wikipedia.org/wiki/File:NADP%2B_phys.svg
  6. commons.wikimedia.org/wiki/F...synthesis2.png
  7. Byrd-Bredbenner C, Moe G, Beshgetoor D, Berning J. (2009) Wardlaw's perspectives in nutrition. New York, NY: McGraw-Hill.
  8. https://fdc.nal.usda.gov/fdc-app.html#/food-details/784416/nutrients
  9. Gropper SS, Smith JL, Groff JL. (2008) Advanced nutrition and human metabolism. Belmont, CA: Wadsworth Publishing.
  10. Said H, Mohammed Z. (2006) Intestinal absorption of water-soluble vitamins: An update. Curr Opin Gastroenterol 22(2): 140-146.
  11. en.Wikipedia.org/wiki/File:CellRespiration.svg
  12. en.Wikipedia.org/wiki/File:Ci...conitate_2.svg
  13. en.Wikipedia.org/wiki/File:Et..._structure.png
  14. en.Wikipedia.org/wiki/Acetal...de-2D-flat.svg
  15. en.Wikipedia.org/wiki/Mitochondrion
  16. https://courses.lumenlearning.com/suny-nutrition/chapter/10-52-niacin-deficiency-toxicity/
  17. en.Wikipedia.org/wiki/File:Pellagra_NIH.jpg
  18. Gille A, Bodor E, Ahmed K, Offermanns S. (2008) Nicotinic acid: Pharmacological effects and mechanisms of action. Annu Rev Pharmacol Toxicol 48: 79-106.
  19. Whitney E, Rolfes SR. (2008) Understanding nutrition. Belmont, CA: Thomson Wadsworth.
  20. Ginsberg HN, Reyes-Soffer G.. (2013) Niacin: A long history, but a questionable future. Curr Opin Lipidol. 24: 475-479.
  21. Liu D, Wang X, Kong L, Chen Z. (2015) Nicotinic acid regulates glucose and lipid metabolism through lipid-independent pathways. Curr Pharm Biotechnol. 16: 3-10.
  22. Meyer-Ficca M, Kirkland JB. (2016). Niacin. Advances in Nutrition, 7:3, 556–558.
  23. Zeman M, Vecka M, Perlík F, et al. (2015). Niacin in the Treatment of Hyperlipidemias in Light of New Clinical Trials: Has Niacin Lost its Place?. Med Sci Monit. 21:2156-2162.

This page titled 10.5: Niacin is shared under a CC BY-NC-SA 4.0 license and was authored, remixed, and/or curated by Brian Lindshield via source content that was edited to the style and standards of the LibreTexts platform.

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