3.4: Connective Tissue

By the end of the section, you will be able to:

• Identify and distinguish between the types of connective tissue: proper, supportive, and fluid
• Explain the functions of connective tissues

As may be obvious from its name, one of the major functions of connective tissue is to connect tissues and organs. Unlike epithelial tissue, which is composed of cells closely packed with little or no extracellular space in between, connective tissue cells are dispersed in a matrix. The matrix usually includes a large amount of extracellular material produced by the connective tissue cells that are embedded within it. The matrix plays a major role in the functioning of this tissue. The major component of the matrix is a ground substance often crisscrossed by protein fibers. This ground substance is usually a fluid, but it can also be mineralized and solid, as in bones. Connective tissues come in a vast variety of forms, yet they typically have in common three characteristic components: cells, large amounts of amorphous ground substance, and protein fibers. The amount and structure of each component correlates with the function of the tissue, from the rigid ground substance in bones supporting the body to the inclusion of specialized cells; for example, phagocytic cells that engulf pathogens and also rid tissue of cellular debris are common in many connective tissues.

Functions of Connective Tissues

Connective tissues perform many functions in the body, but most importantly, they support and connect other tissues; from the connective tissue sheath that surrounds muscle cells, to the tendons that attach muscles to bones, and to the skeleton that supports the positions of the body. Protection is another major function of connective tissue, in the form of fibrous capsules and bones that protect delicate organs and, of course, the skeletal system. Specialized cells in connective tissue defend the body from microorganisms that enter the body. Transport of fluid, nutrients, waste, and chemical messengers is ensured by specialized fluid connective tissues, such as blood and lymph. Adipose cells store surplus energy in the form of fat and contribute to the thermal insulation of the body.

Embryonic Connective Tissue

All connective tissues derive from the mesodermal layer of the embryo. The first connective tissue to develop in the embryo is mesenchyme, the stem cell line from which all connective tissues are later derived. Clusters of mesenchymal cells are scattered throughout adult tissue and supply the cells needed for replacement and repair after a connective tissue injury. A second type of embryonic connective tissue forms in the umbilical cord, called mucous connective tissue or Wharton’s jelly. This tissue is no longer present after birth, leaving only scattered mesenchymal cells throughout the body.

Classification of Connective Tissues

The three broad categories of connective tissue are classified according to the characteristics of their ground substance and the types of fibers found within the matrix (Table \(\PageIndex{1}\)). Connective tissue proper includes loose connective tissue and dense connective tissue. Both tissues have a variety of cell types and protein fibers suspended in a viscous ground substance. Dense connective tissue is reinforced by bundles of fibers that provide tensile strength, elasticity, and protection. In loose connective tissue, the fibers are loosely organized, leaving large spaces in between. Supportive connective tissue—bone and cartilage—provide structure and strength to the body and protect soft tissues. A few distinct cell types and densely packed fibers in a matrix characterize these tissues. In bone, the matrix is rigid and described as calcified because of the deposited calcium salts. In fluid connective tissue, in other words, lymph and blood, various specialized cells circulate in a watery fluid containing salts, nutrients, and dissolved proteins.

Table \(\PageIndex{1}\): Connective Tissue Examples

Connective tissue proper	Supportive connective tissue	Fluid connective tissue
Loose connective tissue Areolar Adipose Reticular	Cartilage Hyaline Fibrocartilage Elastic	Blood
Dense connective tissue Regular elastic Irregular elastic	Bones Compact bone Cancellous bone	Lymph

Connective Tissue Proper

Fibroblasts are present in all connective tissue proper (Figure \(\PageIndex{1}\)). Fibrocytes, adipocytes, and mesenchymal cells are fixed cells, which means they remain within the connective tissue. Other cells move in and out of the connective tissue in response to chemical signals. Macrophages, mast cells, lymphocytes, and plasma cells are found in connective tissue proper but are actually part of the immune system protecting the body.

Figure \(\PageIndex{1}\): Connective Tissue Proper. Fibroblasts produce this fibrous tissue. Connective tissue proper includes the fixed cells fibrocytes, adipocytes, and mesenchymal cells. LM × 400. (Image credit: "Connective Tissue" by OpenStax is licensed under CC BY 3.0/ Micrograph provided by the Regents of University of Michigan Medical School © 2012)

Cell Types

The most abundant cell in connective tissue proper is the fibroblast. Polysaccharides and proteins secreted by fibroblasts combine with extra-cellular fluids to produce a viscous ground substance that, with embedded fibrous proteins, forms the extra-cellular matrix. As you might expect, a fibrocyte, a less active form of fibroblast, is the second most common cell type in connective tissue proper.

Adipocytes are cells that store lipids as droplets that fill most of the cytoplasm. There are two basic types of adipocytes: white and brown. The brown adipocytes store lipids as many droplets, and have high metabolic activity. In contrast, white fat adipocytes store lipids as a single large drop and are metabolically less active. Their effectiveness at storing large amounts of fat is witnessed in obese individuals. The number and type of adipocytes depends on the tissue and location, and vary among individuals in the population.

The mesenchymal cell is a multipotent adult stem cell. These cells can differentiate into any type of connective tissue cells needed for repair and healing of damaged tissue.

The macrophage cell is a large cell derived from a monocyte, a type of blood cell, which enters the connective tissue matrix from the blood vessels. The macrophage cells are an essential component of the immune system, which is the body’s defense against potential pathogens and degraded host cells. When stimulated, macrophages release cytokines, small proteins that act as chemical messengers. Cytokines recruit other cells of the immune system to infected sites and stimulate their activities. Roaming, or free, macrophages move rapidly by amoeboid movement, engulfing infectious agents and cellular debris. In contrast, fixed macrophages are permanent residents of their tissues.

The mast cell, found in connective tissue proper, has many cytoplasmic granules. These granules contain the chemical signals histamine and heparin. When irritated or damaged, mast cells release histamine, an inflammatory mediator, which causes vasodilation and increased blood flow at a site of injury or infection, along with itching, swelling, and redness you recognize as an allergic response. Heparin, also released as part of the inflammatory response, acts as an anticoagulant that prevents the formation of blood clots. Like blood cells, mast cells are derived from hematopoietic stem cells and are part of the immune system.

Connective Tissue Fibers and Ground Substance

Three main types of fibers are secreted by fibroblasts: collagen fibers, elastic fibers, and reticular fibers. Collagen fibers are made from fibrous protein subunits linked together to form a long and straight fiber. Collagen fibers, while flexible, have great tensile strength, resist stretching, and give ligaments and tendons their characteristic resilience and strength. These fibers hold connective tissues together, even during the movement of the body.

Elastic fibers contain the protein elastin along with lesser amounts of other proteins and glycoproteins. The main property of elastin is that after being stretched or compressed, it will return to its original shape. Elastic fibers are prominent in elastic tissues found in skin and the elastic ligaments of the vertebral column.

Reticular fibers are also formed from the same protein subunits as collagen fibers; however, these fibers remain narrow and are arrayed in a branching network. They are found throughout the body, but are most abundant in the reticular tissue of soft organs, such as liver and spleen, where they anchor and provide structural support to the parenchyma (the functional cells, blood vessels, and nerves of the organ).

All of these fiber types are embedded in ground substance. Secreted by fibroblasts, ground substance is made of polysaccharides, specifically hyaluronic acid, and proteins. These combine to form a proteoglycan with a protein core and polysaccharide branches. The proteoglycan attracts and traps available moisture forming the clear, viscous, colorless matrix you now know as ground substance.

Loose Connective Tissue

Loose connective tissue is found between many organs where it acts both to absorb shock and bind tissues together. It allows water, salts, and various nutrients to diffuse through to adjacent or embedded cells and tissues.

Adipose tissue consists mostly of fat storage cells, with little extracellular matrix (Figure \(\PageIndex{2}\)). A large number of capillaries allow rapid storage and mobilization of lipid molecules. White adipose tissue is most abundant. It can appear yellow and owes its color to carotene and related pigments from plant food. White fat contributes mostly to lipid storage and can serve as insulation from cold temperatures and mechanical injuries. White adipose tissue can be found protecting the kidneys and cushioning the back of the eye. Brown adipose tissue is more common in infants, hence the term “baby fat.” In adults, there is a reduced amount of brown fat and it is found mainly in the neck and clavicular regions of the body. The many mitochondria in the cytoplasm of brown adipose tissue help explain its efficiency at metabolizing stored fat. Brown adipose tissue is thermogenic, meaning that as it breaks down fats, it releases metabolic heat, rather than producing adenosine triphosphate (ATP), a key molecule used in metabolism.

Figure \(\PageIndex{2}\): Adipose Tissue. This is a loose connective tissue that consists of fat cells with little extracellular matrix. It stores fat for energy and provides insulation. LM × 800. (Image credit:"Adipose Tissue" by OpenStax is licensed under CC BY 3.0/ Micrograph provided by the Regents of University of Michigan Medical School © 2012)

Areolar tissue shows little specialization. It contains all the cell types and fibers previously described and is distributed in a random, web-like fashion. It fills the spaces between muscle fibers, surrounds blood and lymph vessels, and supports organs in the abdominal cavity. Areolar tissue underlies most epithelia and represents the connective tissue component of epithelial membranes, which are described further in a later section.

Figure \(\PageIndex{3}\): Areolar Connective Tissue. This is a loose connective tissue made up of all components found in connective tissue proper. (Image credit: Left: "Connective Tissue" by OpenStax is licensed under CC BY 3.0; Right: “Areolar Connective Tissue" by Jennifer MacDonald, Histotechnology Program, Mt. San Antonio College is licensed under CC BY-NC 4.0).

Reticular tissue is a mesh-like, supportive framework for soft organs such as lymphatic tissue, the spleen, and the liver (Figure \(\PageIndex{4}\)). Reticular cells produce the reticular fibers that form the network onto which other cells attach. It derives its name from the Latin reticulus, which means “little net.”

Figure \(\PageIndex{4}\): Reticular Tissue. This is a loose connective tissue made up of a network of reticular fibers that provides a supportive framework for soft organs. LM × 1600. (Image credit: "Reticular Tissue" by OpenStax is licensed under CC BY 3.0/ Micrograph provided by the Regents of University of Michigan Medical School © 2012)

Dense Connective Tissue

Dense connective tissue contains more collagen fibers than does loose connective tissue. As a consequence, it displays greater resistance to stretching. There are two major categories of dense connective tissue: regular and irregular. Dense regular connective tissue fibers are parallel to each other, enhancing tensile strength and resistance to stretching in the direction of the fiber orientations. Ligaments and tendons are made of dense regular connective tissue, but in ligaments not all fibers are parallel. Dense regular elastic tissue contains elastic fibers in addition to collagen fibers. Some applications require a ligament to balance tensile strength and elasticity, and thus contain elastic fibers in addition to collagen fibers that allow the ligament to return to its original length after stretching. The ligaments in the vocal folds and between the vertebrae in the vertebral column are composed of dense regular elastic tissue.

In dense irregular connective tissue, the direction of fibers is random. This arrangement gives the tissue greater strength in all directions and less strength in one particular direction. In some tissues, fibers crisscross and form a mesh. In other tissues, stretching in several directions is achieved by alternating layers where fibers run in the same orientation in each layer, and it is the layers themselves that are stacked at an angle. The dermis of the skin is an example of dense irregular connective tissue rich in collagen fibers. As with dense regular connective tissue, when elastic fibers running in random directions outnumber collagen fibers, the tissue is a dense irregular elastic connective tissue. This type of tissue gives the walls of large arteries and respiratory passages strength and the ability to regain original shape after stretching. Examples of typical dense regular and dense irregular connective tissues consisting primarily of collagen fibers are shown in (Figure \(\PageIndex{5}\)).

Figure \(\PageIndex{5}\): Dense Connective Tissue. (a) Dense regular connective tissue consists of collagenous fibers packed into parallel bundles. (b) Dense irregular connective tissue consists of collagenous fibers interwoven into a mesh-like network. From top, LM × 1000, LM × 200. (Image credit: "Reg Dense-Irregular Dense" by OpenStax is licensed under CC BY 3.0/ Micrographs provided by the Regents of University of Michigan Medical School © 2012)

DISORDERS OF THE.....

Connective Tissue: Tendinitis

Your opponent stands ready as you prepare to hit the serve, but you are confident that you will smash the ball past your opponent. As you toss the ball high in the air, a burning pain shoots across your wrist and you drop the tennis racket. That dull ache in the wrist that you ignored through the summer is now an unbearable pain. The game is over for now.

After examining your swollen wrist, the doctor in the emergency room announces that you have developed wrist tendinitis. She recommends icing the tender area, taking non-steroidal anti-inflammatory medication to ease the pain and to reduce swelling, and complete rest for a few weeks. She interrupts your protests that you cannot stop playing. She issues a stern warning about the risk of aggravating the condition and the possibility of surgery. She consoles you by mentioning that well known tennis players such as Venus and Serena Williams and Rafael Nadal have also suffered from tendinitis related injuries.

What is tendinitis and how did it happen? Tendinitis is the inflammation of a tendon, the thick band of dense regular connective tissue that attaches a muscle to a bone. The condition causes pain and tenderness in the area around a joint. On rare occasions, a sudden serious injury will cause tendinitis. Most often, the condition results from repetitive motions over time that strain the tendons needed to perform the tasks.

Persons whose jobs and hobbies involve performing the same movements over and over again are often at the greatest risk of tendinitis. You hear of tennis and golfer’s elbow, jumper's knee, and swimmer’s shoulder. In all cases, overuse of the joint causes a microtrauma that initiates the inflammatory response. Tendinitis is routinely diagnosed through a clinical examination. In case of severe pain, X-rays can be examined to rule out the possibility of a bone injury. Severe cases of tendinitis can even tear loose a tendon. Surgical repair of a tendon is painful. Connective tissue in the tendon does not have abundant blood supply and heals slowly.

While older adults are at risk for tendinitis because the elasticity of tendon tissue decreases with age, active people of all ages can develop tendinitis. Young athletes, dancers, and computer operators; anyone who performs the same movements constantly is at risk for tendinitis. Although repetitive motions are unavoidable in many activities and may lead to tendinitis, precautions can be taken that can lessen the probability of developing tendinitis. For active individuals, dynamic stretches before exercising and cross training or changing exercises are recommended. For the passionate athlete, it may be time to take some lessons to improve technique. All of the preventive measures aim to increase the strength of the tendon and decrease the stress put on it. With proper rest and managed care, you will be back on the court to hit that slice-spin serve over the net.

Supportive Connective Tissues

Two major forms of supportive connective tissue, cartilage and bone, allow the body to maintain its posture and protect internal organs.

Cartilage

The distinctive appearance of cartilage is due to polysaccharides called chondroitin sulfates, which bind with ground substance proteins to form proteoglycans. Embedded within the cartilage matrix are chondrocytes, or cartilage cells, and the space they occupy are called lacunae (singular = lacuna). A layer of dense irregular connective tissue, the perichondrium, encapsulates the cartilage. Cartilaginous tissue is avascular, thus all nutrients need to diffuse through the matrix to reach the chondrocytes. This is a factor contributing to the very slow healing of cartilaginous tissues.

The three main types of cartilage tissue are hyaline cartilage, fibrocartilage, and elastic cartilage (Figure \(\PageIndex{6}\)). Hyaline cartilage, the most common type of cartilage in the body, consists of short and dispersed collagen fibers and contains large amounts of proteoglycans. Under the microscope, tissue samples appear clear. The surface of hyaline cartilage is smooth. Both strong and flexible, it is found in the rib cage and nose and covers bones where they meet to form moveable joints. It makes up a template of the embryonic skeleton before bone formation. A plate of hyaline cartilage at the ends of bone allows continued growth until adulthood. Fibrocartilage is tough because it has thick bundles of collagen fibers dispersed through its matrix, which allows it to resist compression and absorb shock. The knee and jaw joints and the intervertebral discs are examples of fibrocartilage. Elastic cartilage contains elastic fibers as well as collagen and proteoglycans. This tissue gives rigid support as well as elasticity. Tug gently at your ear lobes, and notice that the lobes return to their initial shape. The external ear contains elastic cartilage.

Figure \(\PageIndex{6}\): Types of Cartilage. Cartilage is a connective tissue consisting of collagenous fibers embedded in a firm matrix of chondroitin sulfates. (a) Hyaline cartilage provides support with some flexibility. The example is from dog tissue. (b) Fibrocartilage provides some compressibility and can absorb pressure. (c) Elastic cartilage provides firm but elastic support. From top, LM × 300, LM × 1200, LM × 1016. (Image credit: "Types of Cartilage" by OpenStax is licensed under CC BY 3.0/ Micrographs provided by the Regents of University of Michigan Medical School © 2012)

Bone

Bone is the hardest connective tissue. It provides protection to internal organs and supports the body. Bone’s rigid extracellular matrix contains mostly collagen fibers embedded in a mineralized ground substance containing hydroxyapatite, a form of calcium phosphate. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. Osteocytes, bone cells like chondrocytes, are located within lacunae. The histology of transverse tissue from long bone (Figure \(\PageIndex{7}\)) shows a typical arrangement of osteocytes in concentric circles around a central canal. Bone is a highly vascularized tissue. Unlike cartilage, bone tissue can recover from injuries in a relatively short time.

Cancellous bone, also known as spongy bone, looks like a sponge under the microscope (Figure \(\PageIndex{7}\)) and contains empty spaces between trabeculae, or arches of bone proper. It is lighter than compact bone and found in the interior of some bones and at the end of long bones. Compact bone is solid and has greater structural strength.

Figure \(\PageIndex{7}\): Bone Tissue. (a) Compact Bone Tissue (10x). (b) Cancellous Bone Tissue (10x). (Image credit: “Bone Tissue" by Jennifer MacDonald, Histotechnology Program, Mt. San Antonio College is licensed under CC BY-NC 4.0)

Fluid Connective Tissue

Blood and lymph are fluid connective tissues. Cells circulate in a liquid extracellular matrix. The formed elements circulating in blood are all derived from hematopoietic stem cells located in bone marrow (Figure \(\PageIndex{8}\)). Erythrocytes, red blood cells, transport oxygen and some carbon dioxide. Leukocytes, white blood cells, are responsible for defending against potentially harmful microorganisms or molecules. Platelets are cell fragments involved in blood clotting. Some white blood cells have the ability to cross the endothelial layer that lines blood vessels and enter adjacent tissues. Nutrients, salts, and wastes are dissolved in the liquid matrix and transported through the body.

Lymph contains a liquid matrix and white blood cells. Lymphatic capillaries are extremely permeable, allowing larger molecules and excess fluid from interstitial spaces to enter the lymphatic vessels. Lymph drains into blood vessels, delivering molecules to the blood that could not otherwise directly enter the bloodstream. In this way, specialized lymphatic capillaries transport absorbed fats away from the intestine and deliver these molecules to the blood.

Figure \(\PageIndex{8}\): Blood: A Fluid Connective Tissue. Blood is a fluid connective tissue containing erythrocytes and various types of leukocytes that circulate in a liquid extracellular matrix. LM × 1600. (Image credit: "Blood A Fluid Connective Tissue" by OpenStax is licensed under CC BY 3.0/ Micrograph provided by the Regents of University of Michigan Medical School © 2012)

Organization of Connective Tissues

Recall from the first section of this chapter that membranes form all the body linings and are made up of epithelial tissues with a layer of underlying connective tissue. This is not where connective tissue roles end. As you have seen from the tissue types discussed above, the main role of connective tissues is to form the structural framework of the body. Under membranes there can be several different layers of connective tissues, known as fascia, that function to connect internal structures to the rest of the body. These layers are organized into the superficial fascia, deep fascia, and subserous fascia (Figure \(\PageIndex{9}\)).

The superficial fascia is found just deep to the cutaneous membrane (or skin) and is typically composed of a combination of areolar and adipose connective tissues. It serves to connect the cutaneous membrane to the underlying organs. Under, or deep to, the superficial fascia is the deep fascia. Composed mainly of dense connective tissues, it serves as a tough, internal framework that surrounds muscles, bones, and nerves. Lastly, found in between the deep fascia and the serous membranes, is the subserous fascia. This layer of areolar connective tissue serves as an anchor for the serous membranes to surrounding superficial structures.

Figure \(\PageIndex{9}\): Fascia Organization. There are many layers of connective tissue that form the framework of the human body. These layers, or fascia, are the superficial fascia, deep fascia, and subserous fascia. (Image credit: “Fascia Organization" by Whitney Menefee is a derivative from the original work of Daniel Donnelly and is licensed under CC BY 4.0)

Interactive Link

Connective Tissues

Visit this interactive microscope slide link to test your connective tissue knowledge with this 10-question quiz. Can you name the 10 tissue types shown in the histology slides?

Answer

Answer: Click at the bottom of the quiz for the answers.

Concept Review

Connective tissue is a heterogeneous tissue class with assorted cell shapes and tissue architecture. Structurally, all connective tissues contain cells that are embedded in an extracellular matrix stabilized by proteins. The chemical nature and physical layout of the extracellular matrix and proteins vary enormously among tissues, reflecting the variety of functions that connective tissue fulfills in the body. Connective tissues separate and cushion organs, protecting them from shifting or traumatic injury. Connective tissues provide support and assist movement, store and transport energy molecules, protect against infections, and contribute to temperature homeostasis.

Many different cells contribute to the formation of connective tissues. They originate in the mesodermal germ layer and differentiate from mesenchyme and hematopoietic tissue in the bone marrow. Fibroblasts are the most abundant and secrete many protein fibers, adipocytes specialize in fat storage, hematopoietic cells from the bone marrow give rise to all the blood cells, chondrocytes form cartilage, and osteocytes form bone. The extracellular matrix contains fluid, proteins, polysaccharide derivatives, and, in the case of bone, mineral crystals. Protein fibers fall into three major groups: collagen fibers that are thick, strong, flexible, and resist stretch; reticular fibers that are thin and form a supportive mesh; and elastin fibers that are thin and elastic.

The major types of connective tissue are connective tissue proper, supportive tissue, and fluid tissue. Loose connective tissue proper includes adipose tissue, areolar tissue, and reticular tissue. These serve to hold organs and other tissues in place and, in the case of adipose tissue, isolate and store energy reserves. The matrix is the most abundant feature for loose tissue although adipose tissue does not have much extracellular matrix. Dense connective tissue proper is richer in fibers and may be regular, with fibers oriented in parallel as in ligaments and tendons, or irregular, with fibers oriented in several directions. Organ capsules (collagenous type) and walls of arteries (elastic type) contain dense irregular connective tissue. Cartilage and bone are supportive tissue. Cartilage contains chondrocytes and is somewhat flexible. Hyaline cartilage is smooth and clear, covers the articulating surfaces of bones, and is found in the growing portion of bones. Fibrocartilage is tough because of extra collagen fibers and forms, among other things, the intervertebral discs. Elastic cartilage can stretch and recoil to its original shape because of its high content of elastic fibers. The matrix contains very few blood vessels. Bones are made of a rigid, mineralized matrix containing calcium salts, crystals, and osteocytes lodged in lacunae. Bone tissue is highly vascularized. Cancellous bone is spongy and less solid than compact bone. Fluid tissue, for example blood and lymph, is characterized by a liquid matrix and no supporting fibers.

Review Questions

Q. Connective tissue is made of which three essential components?

A. cells, ground substance, and carbohydrate fibers

B. cells, ground substance, and protein fibers

C. collagen, ground substance, and protein fibers

D. matrix, ground substance, and fluid

Answer

Answer: B

Q. Under the microscope, a tissue specimen shows cells located in spaces scattered in a transparent background. This is probably ________.

A. loose connective tissue

B. a tendon

C. bone

D. hyaline cartilage

Answer

Answer: D

Q. Which connective tissue specializes in storage of fat?

A. tendon

B. adipose tissue

C. reticular tissue

D. dense connective tissue

Answer

Answer: B

Q. Ligaments connect bones together and withstand a lot of stress. What type of connective tissue should you expect ligaments to contain?

A. areolar tissue

B. adipose tissue

C. dense regular connective tissue

D. dense irregular connective tissue

Answer

Answer: C

Q. In adults, new connective tissue cells originate from the ________.

A. mesoderm

B. mesenchyme

C. ectoderm

D. endoderm

Answer

Answer: B

Q. In bone, the main cells are ________.

A. fibroblasts

B. chondrocytes

C. lymphocytes

D. osteocytes

Answer

Answer: D

Critical Thinking Questions

Q. One of the main functions of connective tissue is to integrate organs and organ systems in the body. Discuss how blood fulfills this role.

Answer

A. Blood is a fluid connective tissue, a variety of specialized cells that circulate in a watery fluid containing salts, nutrients, and dissolved proteins in a liquid extracellular matrix. Blood contains formed elements derived from bone marrow. Erythrocytes, or red blood cells, transport the gases oxygen and carbon dioxide. Leukocytes, or white blood cells, are responsible for the defense of the organism against potentially harmful microorganisms or molecules. Platelets are cell fragments involved in blood clotting. Some cells have the ability to cross the endothelial layer that lines vessels and enter adjacent tissues. Nutrients, salts, and waste are dissolved in the liquid matrix and transported through the body.

Q. Why does an injury to cartilage, especially hyaline cartilage, heal much more slowly than a bone fracture?

Answer

A. A layer of dense irregular connective tissue covers cartilage. No blood vessels supply cartilage tissue. Injuries to cartilage heal very slowly because cells and nutrients needed for repair diffuse slowly to the injury site.

Glossary

adipocytes

lipid storage cells

adipose tissue

specialized areolar tissue rich in stored fat

areolar tissue

(also, loose connective tissue) a type of connective tissue proper that shows little specialization with cells dispersed in the matrix

chondrocytes

cells of the cartilage

collagen fiber

flexible fibrous proteins that give connective tissue tensile strength

connective tissue proper

connective tissue containing a viscous matrix, fibers, and cells.

deep fascia

layer of dense connective tissue surrounding muscles, bones, and nerves

dense connective tissue

connective tissue proper that contains many fibers that provide both elasticity and protection

elastic cartilage

type of cartilage, with elastin as the major protein, characterized by rigid support as well as elasticity

elastic fiber

fibrous protein within connective tissue that contains a high percentage of the protein elastin that allows the fibers to stretch and return to original size

fibroblast

most abundant cell type in connective tissue, secretes protein fibers and matrix into the extracellular space

fibrocartilage

tough form of cartilage, made of thick bundles of collagen fibers embedded in chondroitin sulfate ground substance

fibrocyte

less active form of fibroblast

fluid connective tissue

specialized cells that circulate in a watery fluid containing salts, nutrients, and dissolved proteins

ground substance

fluid or semi-fluid portion of the matrix

hyaline cartilage

most common type of cartilage, smooth and made of short collagen fibers embedded in a chondroitin sulfate ground substance

lacunae

(singular = lacuna) small spaces in bone or cartilage tissue that cells occupy

loose connective tissue

(also, areolar tissue) type of connective tissue proper that shows little specialization with cells dispersed in the matrix

matrix

extracellular material which is produced by the cells embedded in it, containing ground substance and fibers

mesenchymal cell

adult stem cell from which most connective tissue cells are derived

mesenchyme

embryonic tissue from which connective tissue cells derive

mucous connective tissue

specialized loose connective tissue present in the umbilical cord

parenchyma

functional cells of a gland or organ, in contrast with the supportive or connective tissue of a gland or organ

reticular fiber

fine fibrous protein, made of collagen subunits, which cross-link to form supporting “nets” within connective tissue

reticular tissue

type of loose connective tissue that provides a supportive framework to soft organs, such as lymphatic tissue, spleen, and the liver

subserous fascia

layer of connective tissues between the deep fascia and serous membranes

superficial fascia

layer of connective tissues found deep to the cutaneous membrane

supportive connective tissue

type of connective tissue that provides strength to the body and protects soft tissue

Contributors and Attributions

• OpenStax Anatomy & Physiology (CC BY 4.0). Access for free at https://openstax.org/books/anatomy-and-physiology