15.5: Parathyroid Glands
By the end of this section, you will be able to:
- Describe the location and structure of the parathyroid glands
- Describe the hormonal control of blood calcium levels
The parathyroid glands are tiny, round structures usually found embedded in the posterior surface of the thyroid gland (Figure \(\PageIndex{1}\)). A thick connective tissue capsule separates the glands from the thyroid tissue. Most people have four parathyroid glands, but occasionally there are more in tissues of the neck or chest.
The primary functional cells of the parathyroid glands are the chief cells. These epithelial cells produce and secrete parathyroid hormone (PTH) , the major hormone involved in the regulation of blood calcium levels (Figure \(\PageIndex{2}\)). When blood calcium levels drop too low, PTH is released from the parathyroid glands into the bloodstream. Parathyroid hormone targets the bones and kidneys. In bones, PTH inhibits osteoblast activity while stimulating osteoclast activity, resulting in stored calcium being released from bone matrix into the bloodstream. In the kidneys, PTH stimulates an increase in calcium reabsorption into the bloodstream and also stimulates the release of calcitriol . Calcitriol targets the intestines to stimulate increased absorption of calcium from food.
When blood calcium levels are high, calcitonin is produced and secreted by the parafollicular cells of the thyroid gland. As discussed in the previous section, calcitonin inhibits the activity of osteoclasts, reduces the absorption of dietary calcium in the intestine, and signals the kidneys to reabsorb less calcium, resulting in larger amounts of calcium excreted in the urine.
DISORDERS OF THE...
Endocrine System: Hyperparathyroidism and Hypoparathyroidism
Abnormally high activity of the parathyroid gland can cause hyperparathyroidism , a disorder caused by an overproduction of PTH that results in excessive calcium reabsorption from bone. Hyperparathyroidism can significantly decrease bone density, leading to spontaneous fractures or deformities. As blood calcium levels rise, cell membrane permeability to sodium is decreased, and the responsiveness of the nervous system is reduced. At the same time, calcium deposits may collect in the body’s tissues and organs, impairing their functioning.
In contrast, abnormally low blood calcium levels may be caused by parathyroid hormone deficiency, called hypoparathyroidism , which may develop following injury or surgery involving the thyroid gland. Low blood calcium increases membrane permeability to sodium, resulting in muscle twitching, cramping, spasms, or convulsions. Severe deficits can paralyze muscles, including those involved in breathing, and can be fatal.
Concept Review
Calcium is required for a variety of important physiologic processes, including neuromuscular functioning; thus, blood calcium levels are closely regulated. The parathyroid glands are small structures located on the posterior of the thyroid gland that produce parathyroid hormone (PTH), which regulates blood calcium levels. Low blood calcium levels cause the production and secretion of PTH. In contrast, elevated blood calcium levels inhibit secretion of PTH and trigger secretion of the thyroid hormone calcitonin. Underproduction of PTH can result in hypoparathyroidism. In contrast, overproduction of PTH can result in hyperparathyroidism.
Review Questions
Q. When blood calcium levels are low, PTH stimulates ________.
A. urinary excretion of calcium by the kidneys
B. a reduction in calcium absorption from the intestines
C. the activity of osteoblasts
D. the activity of osteoclasts
- Answer
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Answer: D
Q. Which of the following can result from hyperparathyroidism?
A. increased bone deposition
B. fractures
C. convulsions
D. all of the above
- Answer
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Answer: B
Critical Thinking Questions
Q. Describe the role of negative feedback in the function of the parathyroid gland.
- Answer
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A. The production and secretion of PTH is regulated by a negative feedback loop. Low blood calcium levels initiate the production and secretion of PTH. PTH increases bone resorption, calcium absorption from the intestines, and calcium reabsorption by the kidneys. As a result, blood calcium levels begin to rise. This, in turn, inhibits the further production and secretion of PTH.
Q. Explain why someone with a parathyroid gland tumor might develop kidney stones.
- Answer
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A. A parathyroid gland tumor can prompt hypersecretion of PTH. This can raise blood calcium levels so excessively that calcium deposits begin to accumulate throughout the body, including in the kidney tubules, where they are referred to as kidney stones.
Glossary
- calcitriol
- hormone released by kidney tubule cells in response to parathyroid hormone that stimulates increased absorption of calcium from digested food in the intestines
- hyperparathyroidism
- disorder caused by overproduction of PTH that results in abnormally elevated blood calcium
- hypoparathyroidism
- disorder caused by underproduction of PTH that results in abnormally low blood calcium
- parathyroid glands
- small, round glands embedded in the posterior thyroid gland that produce parathyroid hormone (PTH)
- parathyroid hormone (PTH)
- peptide hormone produced and secreted by the parathyroid glands that targets bone and the kidneys to raise blood calcium levels and targets the kidneys to release calcitriol
Contributors and Attributions
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OpenStax Anatomy & Physiology (CC BY 4.0). Access for free at https://openstax.org/books/anatomy-and-physiology